Antiviral activity of aqueous and ethanol extracts and of an isolated polysaccharide from Agaricus brasiliensis against poliovirus type 1
Agaricus brasiliensis (previously named Agaricus blazei ss. Heinem), also known as the sun mushroom is native of Southeast Brazil, and is widely consumed, mainly in the form of tea, due to its nutritional and pharmacological properties. In this study, we tested aqueous (AqE) and ethanol (EtOHE) extr...
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| Veröffentlicht in: | Letters in applied microbiology 2007-07, Vol.45 (1), p.24-28 |
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| creator | Faccin, L.C Benati, F Rincão, V.P Mantovani, M.S Soares, S.A Gonzaga, M.L Nozawa, C Carvalho Linhares, R.E |
| description | Agaricus brasiliensis (previously named Agaricus blazei ss. Heinem), also known as the sun mushroom is native of Southeast Brazil, and is widely consumed, mainly in the form of tea, due to its nutritional and pharmacological properties. In this study, we tested aqueous (AqE) and ethanol (EtOHE) extracts and an isolated polysaccharide (PLS) from the fruiting body of A. brasiliensis, for antiviral activity against poliovirus type 1 in HEp-2 cells. The evaluation of the time of addition by plaque assay showed that when AqE, PLS and EtOHE were added, just after the virus inoculation (time 0 h), there was a concentration-dependent reduction in the number of plaques up to 50%, 67% and 88%, respectively, with a selectivity index (SI) of 5·4, 9·9 and 12·3, respectively. The test substances showed antiviral activity and were more effective when added during the poliovirus infection. As they had little effect on reducing viral adsorption and did not show any virucidal effect, we suggest that they act at the initial stage of the replication of poliovirus. These results corroborate that basidiomycetes can be a rich source of potential antiviral compounds. |
| doi_str_mv | 10.1111/j.1472-765X.2007.02153.x |
| format | Article |
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Heinem), also known as the sun mushroom is native of Southeast Brazil, and is widely consumed, mainly in the form of tea, due to its nutritional and pharmacological properties. In this study, we tested aqueous (AqE) and ethanol (EtOHE) extracts and an isolated polysaccharide (PLS) from the fruiting body of A. brasiliensis, for antiviral activity against poliovirus type 1 in HEp-2 cells. The evaluation of the time of addition by plaque assay showed that when AqE, PLS and EtOHE were added, just after the virus inoculation (time 0 h), there was a concentration-dependent reduction in the number of plaques up to 50%, 67% and 88%, respectively, with a selectivity index (SI) of 5·4, 9·9 and 12·3, respectively. The test substances showed antiviral activity and were more effective when added during the poliovirus infection. As they had little effect on reducing viral adsorption and did not show any virucidal effect, we suggest that they act at the initial stage of the replication of poliovirus. These results corroborate that basidiomycetes can be a rich source of potential antiviral compounds.</description><identifier>ISSN: 0266-8254</identifier><identifier>EISSN: 1472-765X</identifier><identifier>DOI: 10.1111/j.1472-765X.2007.02153.x</identifier><identifier>PMID: 17594456</identifier><identifier>CODEN: LAMIE7</identifier><language>eng</language><publisher>Oxford, UK: Oxford, UK : Blackwell Publishing Ltd</publisher><subject>Agaricus - chemistry ; Agaricus - growth & development ; Agaricus blazei ; Agaricus brasiliensis ; antiviral activity ; Antiviral Agents - isolation & purification ; Antiviral Agents - pharmacology ; Antiviral Agents - toxicity ; antiviral properties ; Basidiomycetes ; Biological and medical sciences ; cell culture ; Cell Line, Tumor ; Ethanol - chemistry ; Fundamental and applied biological sciences. Psychology ; Humans ; Microbial Sensitivity Tests ; Microbiology ; plaque assay ; Poliovirus ; Poliovirus - drug effects ; Poliovirus - physiology ; Polysaccharides - isolation & purification ; Polysaccharides - pharmacology ; Polysaccharides - toxicity ; Virus Replication - drug effects ; Water - chemistry</subject><ispartof>Letters in applied microbiology, 2007-07, Vol.45 (1), p.24-28</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5023-6a4158688aaea5a53483c779436a37d7fcd366f28a91ee4417279f9af5a9b8873</citedby><cites>FETCH-LOGICAL-c5023-6a4158688aaea5a53483c779436a37d7fcd366f28a91ee4417279f9af5a9b8873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1472-765X.2007.02153.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1472-765X.2007.02153.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18867834$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17594456$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Faccin, L.C</creatorcontrib><creatorcontrib>Benati, F</creatorcontrib><creatorcontrib>Rincão, V.P</creatorcontrib><creatorcontrib>Mantovani, M.S</creatorcontrib><creatorcontrib>Soares, S.A</creatorcontrib><creatorcontrib>Gonzaga, M.L</creatorcontrib><creatorcontrib>Nozawa, C</creatorcontrib><creatorcontrib>Carvalho Linhares, R.E</creatorcontrib><title>Antiviral activity of aqueous and ethanol extracts and of an isolated polysaccharide from Agaricus brasiliensis against poliovirus type 1</title><title>Letters in applied microbiology</title><addtitle>Lett Appl Microbiol</addtitle><description>Agaricus brasiliensis (previously named Agaricus blazei ss. Heinem), also known as the sun mushroom is native of Southeast Brazil, and is widely consumed, mainly in the form of tea, due to its nutritional and pharmacological properties. In this study, we tested aqueous (AqE) and ethanol (EtOHE) extracts and an isolated polysaccharide (PLS) from the fruiting body of A. brasiliensis, for antiviral activity against poliovirus type 1 in HEp-2 cells. The evaluation of the time of addition by plaque assay showed that when AqE, PLS and EtOHE were added, just after the virus inoculation (time 0 h), there was a concentration-dependent reduction in the number of plaques up to 50%, 67% and 88%, respectively, with a selectivity index (SI) of 5·4, 9·9 and 12·3, respectively. The test substances showed antiviral activity and were more effective when added during the poliovirus infection. As they had little effect on reducing viral adsorption and did not show any virucidal effect, we suggest that they act at the initial stage of the replication of poliovirus. These results corroborate that basidiomycetes can be a rich source of potential antiviral compounds.</description><subject>Agaricus - chemistry</subject><subject>Agaricus - growth & development</subject><subject>Agaricus blazei</subject><subject>Agaricus brasiliensis</subject><subject>antiviral activity</subject><subject>Antiviral Agents - isolation & purification</subject><subject>Antiviral Agents - pharmacology</subject><subject>Antiviral Agents - toxicity</subject><subject>antiviral properties</subject><subject>Basidiomycetes</subject><subject>Biological and medical sciences</subject><subject>cell culture</subject><subject>Cell Line, Tumor</subject><subject>Ethanol - chemistry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>plaque assay</subject><subject>Poliovirus</subject><subject>Poliovirus - drug effects</subject><subject>Poliovirus - physiology</subject><subject>Polysaccharides - isolation & purification</subject><subject>Polysaccharides - pharmacology</subject><subject>Polysaccharides - toxicity</subject><subject>Virus Replication - drug effects</subject><subject>Water - chemistry</subject><issn>0266-8254</issn><issn>1472-765X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc2O0zAQxyMEYsvCK4AvcEvwt50Dh2rFl1TEAVbiZk0du-sqjYudLs0j8NY4pGKv-OIZz-8_45mpKkRwQ8p5u28IV7RWUvxoKMaqwZQI1pwfVat_gcfVClMpa00Fv6qe5bzHGGtC26fVFVGi5VzIVfV7PYzhPiToEdjZGicUPYKfJxdPGcHQITfewRB75M5jKszyODMDCjn2MLoOHWM_ZbD2DlLoHPIpHtB6VxxbkmwT5NAHN-RQxDsIQx5nRYilcImP09Eh8rx64qHP7sXlvq5uP7z_fvOp3nz9-PlmvamtwJTVEjgRWmoN4ECAYFwzq1TLmQSmOuVtx6T0VENLnOOcKKpa34IX0G61Vuy6erPkPaZYusyjOYRsXd_DMLdsKBa4VVwWUC-gTTHn5Lw5pnCANBmCzbwGszfztM08bTOvwfxdgzkX6ctLjdP24LoH4WXuBXh9ASBb6H2CwYb8wGktlWa8cO8W7lfo3fTfHzCb9ZfZKvpXi95DNLBLpcbtN4oJK7CWWAr2B3nmr0Y</recordid><startdate>200707</startdate><enddate>200707</enddate><creator>Faccin, L.C</creator><creator>Benati, F</creator><creator>Rincão, V.P</creator><creator>Mantovani, M.S</creator><creator>Soares, S.A</creator><creator>Gonzaga, M.L</creator><creator>Nozawa, C</creator><creator>Carvalho Linhares, R.E</creator><general>Oxford, UK : Blackwell Publishing Ltd</general><general>Blackwell Publishing Ltd</general><general>Blackwell Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope></search><sort><creationdate>200707</creationdate><title>Antiviral activity of aqueous and ethanol extracts and of an isolated polysaccharide from Agaricus brasiliensis against poliovirus type 1</title><author>Faccin, L.C ; Benati, F ; Rincão, V.P ; Mantovani, M.S ; Soares, S.A ; Gonzaga, M.L ; Nozawa, C ; Carvalho Linhares, R.E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5023-6a4158688aaea5a53483c779436a37d7fcd366f28a91ee4417279f9af5a9b8873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Agaricus - chemistry</topic><topic>Agaricus - growth & development</topic><topic>Agaricus blazei</topic><topic>Agaricus brasiliensis</topic><topic>antiviral activity</topic><topic>Antiviral Agents - isolation & purification</topic><topic>Antiviral Agents - pharmacology</topic><topic>Antiviral Agents - toxicity</topic><topic>antiviral properties</topic><topic>Basidiomycetes</topic><topic>Biological and medical sciences</topic><topic>cell culture</topic><topic>Cell Line, Tumor</topic><topic>Ethanol - chemistry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Microbial Sensitivity Tests</topic><topic>Microbiology</topic><topic>plaque assay</topic><topic>Poliovirus</topic><topic>Poliovirus - drug effects</topic><topic>Poliovirus - physiology</topic><topic>Polysaccharides - isolation & purification</topic><topic>Polysaccharides - pharmacology</topic><topic>Polysaccharides - toxicity</topic><topic>Virus Replication - drug effects</topic><topic>Water - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Faccin, L.C</creatorcontrib><creatorcontrib>Benati, F</creatorcontrib><creatorcontrib>Rincão, V.P</creatorcontrib><creatorcontrib>Mantovani, M.S</creatorcontrib><creatorcontrib>Soares, S.A</creatorcontrib><creatorcontrib>Gonzaga, M.L</creatorcontrib><creatorcontrib>Nozawa, C</creatorcontrib><creatorcontrib>Carvalho Linhares, R.E</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Letters in applied microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Faccin, L.C</au><au>Benati, F</au><au>Rincão, V.P</au><au>Mantovani, M.S</au><au>Soares, S.A</au><au>Gonzaga, M.L</au><au>Nozawa, C</au><au>Carvalho Linhares, R.E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiviral activity of aqueous and ethanol extracts and of an isolated polysaccharide from Agaricus brasiliensis against poliovirus type 1</atitle><jtitle>Letters in applied microbiology</jtitle><addtitle>Lett Appl Microbiol</addtitle><date>2007-07</date><risdate>2007</risdate><volume>45</volume><issue>1</issue><spage>24</spage><epage>28</epage><pages>24-28</pages><issn>0266-8254</issn><eissn>1472-765X</eissn><coden>LAMIE7</coden><abstract>Agaricus brasiliensis (previously named Agaricus blazei ss. Heinem), also known as the sun mushroom is native of Southeast Brazil, and is widely consumed, mainly in the form of tea, due to its nutritional and pharmacological properties. In this study, we tested aqueous (AqE) and ethanol (EtOHE) extracts and an isolated polysaccharide (PLS) from the fruiting body of A. brasiliensis, for antiviral activity against poliovirus type 1 in HEp-2 cells. The evaluation of the time of addition by plaque assay showed that when AqE, PLS and EtOHE were added, just after the virus inoculation (time 0 h), there was a concentration-dependent reduction in the number of plaques up to 50%, 67% and 88%, respectively, with a selectivity index (SI) of 5·4, 9·9 and 12·3, respectively. The test substances showed antiviral activity and were more effective when added during the poliovirus infection. As they had little effect on reducing viral adsorption and did not show any virucidal effect, we suggest that they act at the initial stage of the replication of poliovirus. These results corroborate that basidiomycetes can be a rich source of potential antiviral compounds.</abstract><cop>Oxford, UK</cop><pub>Oxford, UK : Blackwell Publishing Ltd</pub><pmid>17594456</pmid><doi>10.1111/j.1472-765X.2007.02153.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | Agaricus - chemistry Agaricus - growth & development Agaricus blazei Agaricus brasiliensis antiviral activity Antiviral Agents - isolation & purification Antiviral Agents - pharmacology Antiviral Agents - toxicity antiviral properties Basidiomycetes Biological and medical sciences cell culture Cell Line, Tumor Ethanol - chemistry Fundamental and applied biological sciences. Psychology Humans Microbial Sensitivity Tests Microbiology plaque assay Poliovirus Poliovirus - drug effects Poliovirus - physiology Polysaccharides - isolation & purification Polysaccharides - pharmacology Polysaccharides - toxicity Virus Replication - drug effects Water - chemistry |
| title | Antiviral activity of aqueous and ethanol extracts and of an isolated polysaccharide from Agaricus brasiliensis against poliovirus type 1 |
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