IKKβ inhibitors identification part I: Homology model assisted structure based virtual screening

Control of NF-κB release through the inhibition of IKKβ has been identified as a potential target for the treatment of inflammatory and autoimmune diseases. We have employed structure based virtual screening scheme to identify lead like molecule from ChemDiv database. Homology models of IKKβ enzyme...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2009-04, Vol.17 (7), p.2759-2766
Hauptverfasser:	Nagarajan, Shanthi, Doddareddy, Munikumar reddy, Choo, Hyunah, Cho, Yong Seo, Oh, Kwang-Seok, Lee, Byung Ho, Pae, Ae Nim
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Docking Enrichment Flex-X Homology modeling IKK IKKβ Inhibitor kappa B kinase Medical sciences Pharmacology. Drug treatments Pharmacophore constraints Virtual screening
Online-Zugang:	Volltext
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