The Akt-GSK-3 beta axis as a new signaling pathway of the histamine H sub(3) receptor

Drugs targeting the histamine H sub(3) receptor (H sub(3)R) are suggested to be beneficial for the treatment of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. The H sub(3)R activates G sub(i-o)-proteins to inhibit adenylyl cyclase activity and modulates phospholip...

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Veröffentlicht in:Journal of neurochemistry 2007-10, Vol.103 (1), p.248-258
Hauptverfasser: Bongers, Gerold, Sallmen, Tina, Passani, Maria Beatrice, Mariottini, Chiara, Wendelin, Dominique, Lozada, Adrian, Marle, Andre van, Navis, Marjon, Blandina, Patrizio, Bakker, Remko A, Panula, Pertti, Leurs, Rob
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Sprache:eng
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