Muscle Strength Is Associated With Muscle Mass in Patients With Esophageal Cancer Awaiting Surgery
Decreased muscle mass and muscle strength are independent predictors of poor postoperative recovery in patients with esophageal cancer. If there is an association between muscle mass and muscle strength, physiotherapists are able to measure muscle strength as an early predictor for poor postoperativ...
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| Veröffentlicht in: | Journal of geriatric physical therapy (2001) 2020-04, Vol.43 (2), p.82-88 |
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| container_title | Journal of geriatric physical therapy (2001) |
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| creator | van Egmond, Maarten A. van der Schaaf, Marike Hagens, Eliza R. C. van Laarhoven, Hanneke W. M. van Berge Henegouwen, Mark I. Haverkort, Elizabeth B. Engelbert, Raoul H. H. Gisbertz, Suzanne S. |
| description | Decreased muscle mass and muscle strength are independent predictors of poor postoperative recovery in patients with esophageal cancer. If there is an association between muscle mass and muscle strength, physiotherapists are able to measure muscle strength as an early predictor for poor postoperative recovery due to decreased muscle mass. Therefore, in this cross-sectional study, we aimed to investigate the association between muscle mass and muscle strength in predominantly older patients with esophageal cancer awaiting esophagectomy prior to neoadjuvant chemoradiation.
In patients with resectable esophageal cancer eligible for surgery between March 2012 and October 2015, we used computed tomographic scans to assess muscle mass and compared them with muscle strength measures (handgrip strength, inspiratory and expiratory muscle strength, 30 seconds chair stands test). We calculated Pearson correlation coefficients and determined associations by multivariate linear regression analysis.
A tertiary referral center referred 125 individuals to physiotherapy who were eligible for the study; we finally included 93 individuals for statistical analysis. Multiple backward regression analysis showed that gender (95% confidence interval [CI], 2.05-33.82), weight (95% CI, 0.39-1.02), age (95% CI, -0.91 to -0.04), left handgrip strength (95% CI, 0.14-1.44), and inspiratory muscle strength (95% CI, 0.08-0.38) were all independently associated with muscle surface area at L3. All these variables together explained 66% of the variability (R) in muscle surface area at L3 (P < .01).
This study shows an independent association between aspects of muscle strength and muscle mass in patients with esophageal cancer awaiting surgery, and physiotherapists could use the results to predict muscle mass on the basis of muscle strength in preoperative patients with esophageal cancer. |
| doi_str_mv | 10.1519/JPT.0000000000000200 |
| format | Article |
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In patients with resectable esophageal cancer eligible for surgery between March 2012 and October 2015, we used computed tomographic scans to assess muscle mass and compared them with muscle strength measures (handgrip strength, inspiratory and expiratory muscle strength, 30 seconds chair stands test). We calculated Pearson correlation coefficients and determined associations by multivariate linear regression analysis.
A tertiary referral center referred 125 individuals to physiotherapy who were eligible for the study; we finally included 93 individuals for statistical analysis. Multiple backward regression analysis showed that gender (95% confidence interval [CI], 2.05-33.82), weight (95% CI, 0.39-1.02), age (95% CI, -0.91 to -0.04), left handgrip strength (95% CI, 0.14-1.44), and inspiratory muscle strength (95% CI, 0.08-0.38) were all independently associated with muscle surface area at L3. All these variables together explained 66% of the variability (R) in muscle surface area at L3 (P < .01).
This study shows an independent association between aspects of muscle strength and muscle mass in patients with esophageal cancer awaiting surgery, and physiotherapists could use the results to predict muscle mass on the basis of muscle strength in preoperative patients with esophageal cancer.</description><identifier>ISSN: 1539-8412</identifier><identifier>EISSN: 2152-0895</identifier><identifier>DOI: 10.1519/JPT.0000000000000200</identifier><identifier>PMID: 29864049</identifier><language>eng</language><publisher>United States: APTA Geriatrics, An Academy of the American Physical Therapy Association</publisher><subject>Age Factors ; Aged ; Body Weight ; Cross-Sectional Studies ; Esophageal cancer ; Esophageal Neoplasms - physiopathology ; Esophageal Neoplasms - therapy ; Esophagectomy - adverse effects ; Female ; Hand Strength ; Humans ; Male ; Middle Aged ; Muscle function ; Muscle strength ; Muscle, Skeletal - diagnostic imaging ; Muscle, Skeletal - pathology ; Neoadjuvant Therapy ; Physical fitness ; Postoperative Complications - etiology ; Respiratory Muscles - physiopathology ; Strength training ; Tomography, X-Ray Computed</subject><ispartof>Journal of geriatric physical therapy (2001), 2020-04, Vol.43 (2), p.82-88</ispartof><rights>APTA Geriatrics, An Academy of the American Physical Therapy Association.</rights><rights>Copyright Issues on Aging Apr-Jun 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3805-a5787c1a0a5184751cab4797752d2345a137644ff00237bf4523e61bdb5babec3</citedby><cites>FETCH-LOGICAL-c3805-a5787c1a0a5184751cab4797752d2345a137644ff00237bf4523e61bdb5babec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29864049$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Egmond, Maarten A.</creatorcontrib><creatorcontrib>van der Schaaf, Marike</creatorcontrib><creatorcontrib>Hagens, Eliza R. C.</creatorcontrib><creatorcontrib>van Laarhoven, Hanneke W. M.</creatorcontrib><creatorcontrib>van Berge Henegouwen, Mark I.</creatorcontrib><creatorcontrib>Haverkort, Elizabeth B.</creatorcontrib><creatorcontrib>Engelbert, Raoul H. H.</creatorcontrib><creatorcontrib>Gisbertz, Suzanne S.</creatorcontrib><title>Muscle Strength Is Associated With Muscle Mass in Patients With Esophageal Cancer Awaiting Surgery</title><title>Journal of geriatric physical therapy (2001)</title><addtitle>J Geriatr Phys Ther</addtitle><description>Decreased muscle mass and muscle strength are independent predictors of poor postoperative recovery in patients with esophageal cancer. If there is an association between muscle mass and muscle strength, physiotherapists are able to measure muscle strength as an early predictor for poor postoperative recovery due to decreased muscle mass. Therefore, in this cross-sectional study, we aimed to investigate the association between muscle mass and muscle strength in predominantly older patients with esophageal cancer awaiting esophagectomy prior to neoadjuvant chemoradiation.
In patients with resectable esophageal cancer eligible for surgery between March 2012 and October 2015, we used computed tomographic scans to assess muscle mass and compared them with muscle strength measures (handgrip strength, inspiratory and expiratory muscle strength, 30 seconds chair stands test). We calculated Pearson correlation coefficients and determined associations by multivariate linear regression analysis.
A tertiary referral center referred 125 individuals to physiotherapy who were eligible for the study; we finally included 93 individuals for statistical analysis. Multiple backward regression analysis showed that gender (95% confidence interval [CI], 2.05-33.82), weight (95% CI, 0.39-1.02), age (95% CI, -0.91 to -0.04), left handgrip strength (95% CI, 0.14-1.44), and inspiratory muscle strength (95% CI, 0.08-0.38) were all independently associated with muscle surface area at L3. All these variables together explained 66% of the variability (R) in muscle surface area at L3 (P < .01).
This study shows an independent association between aspects of muscle strength and muscle mass in patients with esophageal cancer awaiting surgery, and physiotherapists could use the results to predict muscle mass on the basis of muscle strength in preoperative patients with esophageal cancer.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Body Weight</subject><subject>Cross-Sectional Studies</subject><subject>Esophageal cancer</subject><subject>Esophageal Neoplasms - physiopathology</subject><subject>Esophageal Neoplasms - therapy</subject><subject>Esophagectomy - adverse effects</subject><subject>Female</subject><subject>Hand Strength</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Muscle function</subject><subject>Muscle strength</subject><subject>Muscle, Skeletal - diagnostic imaging</subject><subject>Muscle, Skeletal - pathology</subject><subject>Neoadjuvant Therapy</subject><subject>Physical fitness</subject><subject>Postoperative Complications - etiology</subject><subject>Respiratory Muscles - physiopathology</subject><subject>Strength training</subject><subject>Tomography, X-Ray Computed</subject><issn>1539-8412</issn><issn>2152-0895</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkV1P2zAUhi3ENDrYP5gmS9zsJsyfcXxZVYwxgUACxKXluCdtIE2Kj6OKf4-rdmzCN5bs5zyy35eQb5ydcc3tzz-392fs_yUYOyATwbUoWGX1IZlwLW1RKS6OyBfEJ8aktLL6TI6ErUrFlJ2Q-nrE0AG9SxH6RVrSS6RTxCG0PsGcPrb5aI9ce0Ta9vTWpxb6hLvLcxzWS78A39GZ7wNEOt34NrX9gt6NcQHx9YR8anyH8HW_H5OHX-f3s9_F1c3F5Wx6VQRZMV14bSoTuGde80oZzYOvlbHGaDEXUmnPpSmVapr8U2nqRmkhoeT1vNa1ryHIY_Jj513H4WUETG7VYoCu8z0MIzrBNFM5GKYyevoBfRrG2OfXOSGtEiXXpsyU2lEhDogRGreO7crHV8eZ23bgcgfuYwd57PtePtYrmL8P_Q39n3czdAkiPnfjBqJb5gzTMvu4tFzJQmxtKkuLrVnLNyt3j3M</recordid><startdate>202004</startdate><enddate>202004</enddate><creator>van Egmond, Maarten A.</creator><creator>van der Schaaf, Marike</creator><creator>Hagens, Eliza R. C.</creator><creator>van Laarhoven, Hanneke W. M.</creator><creator>van Berge Henegouwen, Mark I.</creator><creator>Haverkort, Elizabeth B.</creator><creator>Engelbert, Raoul H. H.</creator><creator>Gisbertz, Suzanne S.</creator><general>APTA Geriatrics, An Academy of the American Physical Therapy Association</general><general>Issues on Aging</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>4T-</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>202004</creationdate><title>Muscle Strength Is Associated With Muscle Mass in Patients With Esophageal Cancer Awaiting Surgery</title><author>van Egmond, Maarten A. ; van der Schaaf, Marike ; Hagens, Eliza R. C. ; van Laarhoven, Hanneke W. M. ; van Berge Henegouwen, Mark I. ; Haverkort, Elizabeth B. ; Engelbert, Raoul H. H. ; Gisbertz, Suzanne S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3805-a5787c1a0a5184751cab4797752d2345a137644ff00237bf4523e61bdb5babec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Body Weight</topic><topic>Cross-Sectional Studies</topic><topic>Esophageal cancer</topic><topic>Esophageal Neoplasms - physiopathology</topic><topic>Esophageal Neoplasms - therapy</topic><topic>Esophagectomy - adverse effects</topic><topic>Female</topic><topic>Hand Strength</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Muscle function</topic><topic>Muscle strength</topic><topic>Muscle, Skeletal - diagnostic imaging</topic><topic>Muscle, Skeletal - pathology</topic><topic>Neoadjuvant Therapy</topic><topic>Physical fitness</topic><topic>Postoperative Complications - etiology</topic><topic>Respiratory Muscles - physiopathology</topic><topic>Strength training</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Egmond, Maarten A.</creatorcontrib><creatorcontrib>van der Schaaf, Marike</creatorcontrib><creatorcontrib>Hagens, Eliza R. C.</creatorcontrib><creatorcontrib>van Laarhoven, Hanneke W. M.</creatorcontrib><creatorcontrib>van Berge Henegouwen, Mark I.</creatorcontrib><creatorcontrib>Haverkort, Elizabeth B.</creatorcontrib><creatorcontrib>Engelbert, Raoul H. H.</creatorcontrib><creatorcontrib>Gisbertz, Suzanne S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Docstoc</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of geriatric physical therapy (2001)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Egmond, Maarten A.</au><au>van der Schaaf, Marike</au><au>Hagens, Eliza R. C.</au><au>van Laarhoven, Hanneke W. M.</au><au>van Berge Henegouwen, Mark I.</au><au>Haverkort, Elizabeth B.</au><au>Engelbert, Raoul H. H.</au><au>Gisbertz, Suzanne S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Muscle Strength Is Associated With Muscle Mass in Patients With Esophageal Cancer Awaiting Surgery</atitle><jtitle>Journal of geriatric physical therapy (2001)</jtitle><addtitle>J Geriatr Phys Ther</addtitle><date>2020-04</date><risdate>2020</risdate><volume>43</volume><issue>2</issue><spage>82</spage><epage>88</epage><pages>82-88</pages><issn>1539-8412</issn><eissn>2152-0895</eissn><abstract>Decreased muscle mass and muscle strength are independent predictors of poor postoperative recovery in patients with esophageal cancer. If there is an association between muscle mass and muscle strength, physiotherapists are able to measure muscle strength as an early predictor for poor postoperative recovery due to decreased muscle mass. Therefore, in this cross-sectional study, we aimed to investigate the association between muscle mass and muscle strength in predominantly older patients with esophageal cancer awaiting esophagectomy prior to neoadjuvant chemoradiation.
In patients with resectable esophageal cancer eligible for surgery between March 2012 and October 2015, we used computed tomographic scans to assess muscle mass and compared them with muscle strength measures (handgrip strength, inspiratory and expiratory muscle strength, 30 seconds chair stands test). We calculated Pearson correlation coefficients and determined associations by multivariate linear regression analysis.
A tertiary referral center referred 125 individuals to physiotherapy who were eligible for the study; we finally included 93 individuals for statistical analysis. Multiple backward regression analysis showed that gender (95% confidence interval [CI], 2.05-33.82), weight (95% CI, 0.39-1.02), age (95% CI, -0.91 to -0.04), left handgrip strength (95% CI, 0.14-1.44), and inspiratory muscle strength (95% CI, 0.08-0.38) were all independently associated with muscle surface area at L3. All these variables together explained 66% of the variability (R) in muscle surface area at L3 (P < .01).
This study shows an independent association between aspects of muscle strength and muscle mass in patients with esophageal cancer awaiting surgery, and physiotherapists could use the results to predict muscle mass on the basis of muscle strength in preoperative patients with esophageal cancer.</abstract><cop>United States</cop><pub>APTA Geriatrics, An Academy of the American Physical Therapy Association</pub><pmid>29864049</pmid><doi>10.1519/JPT.0000000000000200</doi><tpages>7</tpages></addata></record> |
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| subjects | Age Factors Aged Body Weight Cross-Sectional Studies Esophageal cancer Esophageal Neoplasms - physiopathology Esophageal Neoplasms - therapy Esophagectomy - adverse effects Female Hand Strength Humans Male Middle Aged Muscle function Muscle strength Muscle, Skeletal - diagnostic imaging Muscle, Skeletal - pathology Neoadjuvant Therapy Physical fitness Postoperative Complications - etiology Respiratory Muscles - physiopathology Strength training Tomography, X-Ray Computed |
| title | Muscle Strength Is Associated With Muscle Mass in Patients With Esophageal Cancer Awaiting Surgery |
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