Dopaminergic Lesion in the Olfactory Bulb Restores Olfaction and Induces Depressive-Like Behaviors in a 6-OHDA Model of Parkinson’s Disease

Olfactory impairments and depressive behavior are commonly reported by individuals with Parkinson’s disease (PD) being observed before motor symptoms. The mechanisms underlying these clinical manifestations are not fully elucidated. However, the imbalance in dopaminergic neurotransmission seems to p...

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Veröffentlicht in:	Molecular neurobiology 2019-02, Vol.56 (2), p.1082-1095
Hauptverfasser:	Ilkiw, Jessica L., Kmita, Luana C., Targa, Adriano D. S., Noseda, Ana Carolina D., Rodrigues, Lais S., Dorieux, Flávia W. C., Fagotti, Juliane, dos Santos, Patrícia, Lima, Marcelo M. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Hydroxydopamine Animal models Animals Behavior Behavior, Animal - drug effects Biomedical and Life Sciences Biomedicine Cell Biology Depression - chemically induced Disease Models, Animal Dopamine - metabolism Dopamine receptors Dopaminergic Neurons - drug effects Dopaminergic Neurons - metabolism Interneurons Lesions Male Mental depression Movement disorders Neurobiology Neurodegenerative diseases Neurology Neurosciences Neurotransmission Olfaction Olfaction disorders Olfactory bulb Olfactory Bulb - drug effects Olfactory Bulb - injuries Olfactory Bulb - pathology Parkinson Disease - drug therapy Parkinson Disease - pathology Parkinson's disease Rats, Wistar Substantia nigra Substantia Nigra - drug effects Substantia Nigra - pathology
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