Ataxin‐2: A versatile posttranscriptional regulator and its implication in neural function

Ataxin‐2 (ATXN2) is a eukaryotic RNA‐binding protein that is conserved from yeast to human. Genetic expansion of a poly‐glutamine tract in human ATXN2 has been implicated in several neurodegenerative diseases, likely acting through gain‐of‐function effects. Emerging evidence, however, suggests that...

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Veröffentlicht in:	Wiley interdisciplinary reviews. RNA 2018-11, Vol.9 (6), p.e1488-n/a
Hauptverfasser:	Lee, Jongbo, Kim, Minjong, Itoh, Taichi Q., Lim, Chunghun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ataxin Ataxin-2 - chemistry Ataxin-2 - physiology Ataxin‐2 (ATXN2) Circadian rhythms Disease Gene expression Gene silencing Glutamine Habituation Homeostasis Humans miRNA Molecular evolution neural function Neurodegenerative diseases Neurodegenerative Diseases - genetics Neurodegenerative Diseases - metabolism Neurological diseases Post-transcription posttranscriptional gene regulation Proteins Rapamycin RNA - metabolism RNA Processing, Post-Transcriptional RNA-binding protein Therapeutic applications TOR protein
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