Anti-androgenic activities of the triterpenoids fraction of Ganoderma lucidum

Anti-androgenic activities of the triterpenoids fraction of Ganoderma lucidum

The ethanol extract of Ganoderma lucidum showed inhibitory activity on both isozymes (types 1 and 2) of 5α-reductase and suppression effects of ventral prostate growth induced by testosterone in castrated rat, but not induced by dihydrotestosterone. Activity-guided fractionation and TLC analysis sug...

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Veröffentlicht in:Food chemistry 2007, Vol.100 (4), p.1691-1696
Hauptverfasser: Liu, Jie, Shimizu, Kuniyoshi, Konishi, Fumiko, Noda, Kiyoshi, Kumamoto, Shoichiro, Kurashiki, Kenji, Kondo, Ryuichiro
Format: Artikel
Sprache:eng
Schlagworte:
5α-Reductase
androgens
animal models
Anti-androgen activities
Benign prostatic hyperplasia
enzyme inhibition
food chemistry
Ganoderma lucidum
isozymes
medicinal plants
plant extracts
prostate gland
rats
traditional medicine
Triterpenoid
triterpenoids
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Zusammenfassung:The ethanol extract of Ganoderma lucidum showed inhibitory activity on both isozymes (types 1 and 2) of 5α-reductase and suppression effects of ventral prostate growth induced by testosterone in castrated rat, but not induced by dihydrotestosterone. Activity-guided fractionation and TLC analysis suggested that the active principles in vivo were triterpenoids. These results indicate that the triterpenoids fraction of G. lucidum might be a useful ingredient in the treatment of benign prostatic hyperplasia.
ISSN:0308-8146
1873-7072
DOI:10.1016/j.foodchem.2006.01.003