Silibinin sensitizes human glioma cells to TRAIL-mediated apoptosis via DR5 up-regulation and down-regulation of c-FLIP and survivin

Silibinin, a flavonoid isolated from Silybum marianum, has been reported to have cancer chemopreventive and therapeutic effects. Here, we show that treatment with subtoxic doses of silibinin in combination with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces rapid apoptosis i...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2007-09, Vol.67 (17), p.8274-8284
Hauptverfasser:	Son, Yong-Gyu, Kim, Eun Hee, Kim, Jin Yeop, Kim, Seung U, Kwon, Taeg Kyu, Yoon, A-Rum, Yun, Chae-Ok, Choi, Kyeong Sook
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants - pharmacology Apoptosis - drug effects Astrocytes - drug effects CASP8 and FADD-Like Apoptosis Regulating Protein - genetics Caspases - metabolism Drug Combinations Drug Evaluation, Preclinical Drug Synergism Gene Expression Regulation, Neoplastic - drug effects Glioma - genetics Glioma - pathology Humans Inhibitor of Apoptosis Proteins Microtubule-Associated Proteins - genetics Neoplasm Proteins - genetics Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics Silybum marianum Silymarin - pharmacology TNF-Related Apoptosis-Inducing Ligand - pharmacology Transcription Factor CHOP - metabolism Tumor Cells, Cultured
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