The mitochondrial KATP channel opener BMS-191095 induces neuronal preconditioning
BMS-191095, reportedly a selective mitoKATP channel opener which is free from the known side effects of the prototype mitoKATP channel opener diazoxide, induced acute and delayed preconditioning against glutamate excitotoxicity and delayed preconditioning against oxygen–glucose deprivation in primar...
Gespeichert in:
| Veröffentlicht in: | Neuroreport 2004-02, Vol.15 (2), p.345-349 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 349 |
|---|---|
| container_issue | 2 |
| container_start_page | 345 |
| container_title | Neuroreport |
| container_volume | 15 |
| creator | Kis, Bela Nagy, Krisztina Snipes, James A Rajapakse, Nishadi C Horiguchi, Takashi Grover, Gary J Busija, David W |
| description | BMS-191095, reportedly a selective mitoKATP channel opener which is free from the known side effects of the prototype mitoKATP channel opener diazoxide, induced acute and delayed preconditioning against glutamate excitotoxicity and delayed preconditioning against oxygen–glucose deprivation in primary cultures of rat cortical neurons. BMS-191095 dose dependently depolarized the mitochondria, increased the phosphorylation of PKC isoforms, but had no detectable effects on the activation of MAP kinases and did not influence the expressions of HSP70 and Mn-SOD. In BMS-191095-preconditioned neurons the glutamate-induced free-radical production was abolished. Our data give the first evidence that selective opening of mitoKATP channels with BMS-191095 leads to remarkable neuroprotection via mechanisms that involve mitochondrial depolarization, PKC activation and attenuated free radical production during neuronal stress. |
| doi_str_mv | 10.1097/00001756-200402090-00027 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_20501771</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20501771</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3447-7308b000d495bbba034d7cfb0830f07bfe5f99b2ecbbdf0c290d5a310ff10bd63</originalsourceid><addsrcrecordid>eNp1kdFOHCEUhklTk25X32Fu7N3oYWZYhks1VRttqnGbeEeAOThUFrYwE-Pbl7pWr3puSE6-n598EFJROKIg-DGUoZyt6gaggwYE1GXT8A9kQTve1oz19x_JAgQTdSdW7BP5nPOvggig_YLcrkesNm6KZoxhSE756upkfVOZUYWAvopbDJiq0-93NRWlkFUuDLPBXAWcUwyF3yY0JesmF4MLD_tkzyqf8eD1XJKf51_XZ5f19Y-Lb2cn17Vpu47XvIVel2cMnWBaawVtN3BjNfQtWODaIrNC6AaN1oMF0wgYmGopWEtBD6t2Sb7s7t2m-HvGPMmNywa9VwHjnGUDrIjhtID9DjQp5pzQym1yG5WeJQX516H851C-OZQvDkv08LVDZaO8TSoYl9_zRW4jVqJw3Y57in7ClB_9_IRJjqj8NMr_fVH7Bwr9gGc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20501771</pqid></control><display><type>article</type><title>The mitochondrial KATP channel opener BMS-191095 induces neuronal preconditioning</title><source>Journals@Ovid Complete</source><creator>Kis, Bela ; Nagy, Krisztina ; Snipes, James A ; Rajapakse, Nishadi C ; Horiguchi, Takashi ; Grover, Gary J ; Busija, David W</creator><creatorcontrib>Kis, Bela ; Nagy, Krisztina ; Snipes, James A ; Rajapakse, Nishadi C ; Horiguchi, Takashi ; Grover, Gary J ; Busija, David W</creatorcontrib><description>BMS-191095, reportedly a selective mitoKATP channel opener which is free from the known side effects of the prototype mitoKATP channel opener diazoxide, induced acute and delayed preconditioning against glutamate excitotoxicity and delayed preconditioning against oxygen–glucose deprivation in primary cultures of rat cortical neurons. BMS-191095 dose dependently depolarized the mitochondria, increased the phosphorylation of PKC isoforms, but had no detectable effects on the activation of MAP kinases and did not influence the expressions of HSP70 and Mn-SOD. In BMS-191095-preconditioned neurons the glutamate-induced free-radical production was abolished. Our data give the first evidence that selective opening of mitoKATP channels with BMS-191095 leads to remarkable neuroprotection via mechanisms that involve mitochondrial depolarization, PKC activation and attenuated free radical production during neuronal stress.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/00001756-200402090-00027</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Biological and medical sciences ; Fundamental and applied biological sciences. Psychology ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroreport, 2004-02, Vol.15 (2), p.345-349</ispartof><rights>2004 Lippincott Williams & Wilkins, Inc.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3447-7308b000d495bbba034d7cfb0830f07bfe5f99b2ecbbdf0c290d5a310ff10bd63</citedby><cites>FETCH-LOGICAL-c3447-7308b000d495bbba034d7cfb0830f07bfe5f99b2ecbbdf0c290d5a310ff10bd63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15582969$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Kis, Bela</creatorcontrib><creatorcontrib>Nagy, Krisztina</creatorcontrib><creatorcontrib>Snipes, James A</creatorcontrib><creatorcontrib>Rajapakse, Nishadi C</creatorcontrib><creatorcontrib>Horiguchi, Takashi</creatorcontrib><creatorcontrib>Grover, Gary J</creatorcontrib><creatorcontrib>Busija, David W</creatorcontrib><title>The mitochondrial KATP channel opener BMS-191095 induces neuronal preconditioning</title><title>Neuroreport</title><description>BMS-191095, reportedly a selective mitoKATP channel opener which is free from the known side effects of the prototype mitoKATP channel opener diazoxide, induced acute and delayed preconditioning against glutamate excitotoxicity and delayed preconditioning against oxygen–glucose deprivation in primary cultures of rat cortical neurons. BMS-191095 dose dependently depolarized the mitochondria, increased the phosphorylation of PKC isoforms, but had no detectable effects on the activation of MAP kinases and did not influence the expressions of HSP70 and Mn-SOD. In BMS-191095-preconditioned neurons the glutamate-induced free-radical production was abolished. Our data give the first evidence that selective opening of mitoKATP channels with BMS-191095 leads to remarkable neuroprotection via mechanisms that involve mitochondrial depolarization, PKC activation and attenuated free radical production during neuronal stress.</description><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNp1kdFOHCEUhklTk25X32Fu7N3oYWZYhks1VRttqnGbeEeAOThUFrYwE-Pbl7pWr3puSE6-n598EFJROKIg-DGUoZyt6gaggwYE1GXT8A9kQTve1oz19x_JAgQTdSdW7BP5nPOvggig_YLcrkesNm6KZoxhSE756upkfVOZUYWAvopbDJiq0-93NRWlkFUuDLPBXAWcUwyF3yY0JesmF4MLD_tkzyqf8eD1XJKf51_XZ5f19Y-Lb2cn17Vpu47XvIVel2cMnWBaawVtN3BjNfQtWODaIrNC6AaN1oMF0wgYmGopWEtBD6t2Sb7s7t2m-HvGPMmNywa9VwHjnGUDrIjhtID9DjQp5pzQym1yG5WeJQX516H851C-OZQvDkv08LVDZaO8TSoYl9_zRW4jVqJw3Y57in7ClB_9_IRJjqj8NMr_fVH7Bwr9gGc</recordid><startdate>20040209</startdate><enddate>20040209</enddate><creator>Kis, Bela</creator><creator>Nagy, Krisztina</creator><creator>Snipes, James A</creator><creator>Rajapakse, Nishadi C</creator><creator>Horiguchi, Takashi</creator><creator>Grover, Gary J</creator><creator>Busija, David W</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>20040209</creationdate><title>The mitochondrial KATP channel opener BMS-191095 induces neuronal preconditioning</title><author>Kis, Bela ; Nagy, Krisztina ; Snipes, James A ; Rajapakse, Nishadi C ; Horiguchi, Takashi ; Grover, Gary J ; Busija, David W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3447-7308b000d495bbba034d7cfb0830f07bfe5f99b2ecbbdf0c290d5a310ff10bd63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Biological and medical sciences</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kis, Bela</creatorcontrib><creatorcontrib>Nagy, Krisztina</creatorcontrib><creatorcontrib>Snipes, James A</creatorcontrib><creatorcontrib>Rajapakse, Nishadi C</creatorcontrib><creatorcontrib>Horiguchi, Takashi</creatorcontrib><creatorcontrib>Grover, Gary J</creatorcontrib><creatorcontrib>Busija, David W</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kis, Bela</au><au>Nagy, Krisztina</au><au>Snipes, James A</au><au>Rajapakse, Nishadi C</au><au>Horiguchi, Takashi</au><au>Grover, Gary J</au><au>Busija, David W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The mitochondrial KATP channel opener BMS-191095 induces neuronal preconditioning</atitle><jtitle>Neuroreport</jtitle><date>2004-02-09</date><risdate>2004</risdate><volume>15</volume><issue>2</issue><spage>345</spage><epage>349</epage><pages>345-349</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>BMS-191095, reportedly a selective mitoKATP channel opener which is free from the known side effects of the prototype mitoKATP channel opener diazoxide, induced acute and delayed preconditioning against glutamate excitotoxicity and delayed preconditioning against oxygen–glucose deprivation in primary cultures of rat cortical neurons. BMS-191095 dose dependently depolarized the mitochondria, increased the phosphorylation of PKC isoforms, but had no detectable effects on the activation of MAP kinases and did not influence the expressions of HSP70 and Mn-SOD. In BMS-191095-preconditioned neurons the glutamate-induced free-radical production was abolished. Our data give the first evidence that selective opening of mitoKATP channels with BMS-191095 leads to remarkable neuroprotection via mechanisms that involve mitochondrial depolarization, PKC activation and attenuated free radical production during neuronal stress.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><doi>10.1097/00001756-200402090-00027</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0959-4965 |
| ispartof | Neuroreport, 2004-02, Vol.15 (2), p.345-349 |
| issn | 0959-4965 1473-558X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_20501771 |
| source | Journals@Ovid Complete |
| subjects | Biological and medical sciences Fundamental and applied biological sciences. Psychology Vertebrates: nervous system and sense organs |
| title | The mitochondrial KATP channel opener BMS-191095 induces neuronal preconditioning |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T04%3A12%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20mitochondrial%20KATP%20channel%20opener%20BMS-191095%20induces%20neuronal%20preconditioning&rft.jtitle=Neuroreport&rft.au=Kis,%20Bela&rft.date=2004-02-09&rft.volume=15&rft.issue=2&rft.spage=345&rft.epage=349&rft.pages=345-349&rft.issn=0959-4965&rft.eissn=1473-558X&rft_id=info:doi/10.1097/00001756-200402090-00027&rft_dat=%3Cproquest_cross%3E20501771%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=20501771&rft_id=info:pmid/&rfr_iscdi=true |