Novel leucine ureido derivatives as aminopeptidase N inhibitors using click chemistry

[Display omitted] •New aminopeptidase N inhibitors have been designed and rapidly synthesized with click chemistry.•Some compounds presented sub-micromolar inhibitory activities against APN.•The best compound 13v demonstrated promising potent in vitro anti-angiogenesis activity and in vivo anti-meta...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Bioorganic & medicinal chemistry 2018-07, Vol.26 (12), p.3145-3157
Hauptverfasser:	Cao, Jiangying, Ma, Chunhua, Zang, Jie, Gao, Shuai, Gao, Qianwen, Kong, Xiujie, Yan, Yugang, Liang, Xuewu, Ding, Qin'ge, Zhao, Chunlong, Wang, Binghe, Xu, Wenfang, Zhang, Yingjie
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminopeptidase N Anti-angiogenesis Anti-metastasis CD13 Triazole
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!