Okadaic acid–induced tau hyperphosphorylation and the downregulation of Pin1 expression in primary cortical neurons

•OKA-induced tau hyperphosphorylation is confirmed as a valid model.•Tau hyperphosphorylation may cause some alterations in brain microenvironment via Pin1.•The effect of OKA on tau hyperphosphorylation and Pin1 might be two different mechanisms. Hyperphosphorylation of tau leading to neurofibrillar...

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Veröffentlicht in:	Journal of chemical neuroanatomy 2018-10, Vol.92, p.41-47
Hauptverfasser:	Metin-Armağan, Derya, Gezen-Ak, Duygu, Dursun, Erdinç, Atasoy, İrem Lütfiye, Karabay, Arzu, Yılmazer, Selma, Öztürk, Melek
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer’s disease OKA Pin1 Primary cortical neuron Tau Tauopathy
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