A systematic review exploring the relationship between infection and sudden unexpected death between 2000 and 2016: A forensic perspective
•Forensic autopsies of sudden death cases may reveal infectious cause of death.•Bacterial pathogens were most commonly associated with these deaths.•Risk factors in infants were exposure to tobacco smoke and co-sleeping.•Risk factors in adults were co-morbid conditions and illnesses.•Research in thi...
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| Veröffentlicht in: | Forensic science international 2018-08, Vol.289, p.108-119 |
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| creator | Kruger, Mia M. Martin, Lorna J. Maistry, Sairita Heathfield, Laura J. |
| description | •Forensic autopsies of sudden death cases may reveal infectious cause of death.•Bacterial pathogens were most commonly associated with these deaths.•Risk factors in infants were exposure to tobacco smoke and co-sleeping.•Risk factors in adults were co-morbid conditions and illnesses.•Research in this field is particularly scarce in developing countries.
Death due to infectious diseases is a major health concern worldwide. This is of particular concern in developing countries where poor-socio economic status and a lack of healthcare resources contribute to the high burden of disease. In some cases death due to infection can be acute and aggressive, and death may occur without a diagnosis whilst the person is still alive. These deaths may ultimately lead to a medico-legal autopsy being performed. There are various mechanisms by which sudden death due to infection may occur. In addition, there are many risk factors associated with sudden death due to infection, which differ between infants and older individuals. However, it is unclear which pathogens and risk factors are most frequently associated with sudden death due to infection. Therefore a systematic review of articles and case reports published between 1 January 2000 and 30 June 2016 was undertaken in order to (1) explore the relationship between pathogens and their causative role and (2) identify the relationship between predisposing and/or risk factors associated with sudden death due to infection. Major databases were searched and after critical appraisal 143 articles were identified. It was found that respiratory infections and deaths involving bacterial pathogens were most commonly associated with these deaths. In addition the most common risk factors in infants were exposure to tobacco smoke and co-sleeping. In adults the most common risk factors were co-morbid conditions and illnesses. This information aids in a better understanding of these deaths and highlights the need for more research in this field, particularly in developing countries |
| doi_str_mv | 10.1016/j.forsciint.2018.05.023 |
| format | Article |
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Death due to infectious diseases is a major health concern worldwide. This is of particular concern in developing countries where poor-socio economic status and a lack of healthcare resources contribute to the high burden of disease. In some cases death due to infection can be acute and aggressive, and death may occur without a diagnosis whilst the person is still alive. These deaths may ultimately lead to a medico-legal autopsy being performed. There are various mechanisms by which sudden death due to infection may occur. In addition, there are many risk factors associated with sudden death due to infection, which differ between infants and older individuals. However, it is unclear which pathogens and risk factors are most frequently associated with sudden death due to infection. Therefore a systematic review of articles and case reports published between 1 January 2000 and 30 June 2016 was undertaken in order to (1) explore the relationship between pathogens and their causative role and (2) identify the relationship between predisposing and/or risk factors associated with sudden death due to infection. Major databases were searched and after critical appraisal 143 articles were identified. It was found that respiratory infections and deaths involving bacterial pathogens were most commonly associated with these deaths. In addition the most common risk factors in infants were exposure to tobacco smoke and co-sleeping. In adults the most common risk factors were co-morbid conditions and illnesses. This information aids in a better understanding of these deaths and highlights the need for more research in this field, particularly in developing countries</description><identifier>ISSN: 0379-0738</identifier><identifier>EISSN: 1872-6283</identifier><identifier>DOI: 10.1016/j.forsciint.2018.05.023</identifier><identifier>PMID: 29860163</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Acquired immune deficiency syndrome ; Adenoviruses ; Adults ; AIDS ; Alcohol ; Autopsies ; Autopsy ; Babies ; Case reports ; Chicken pox ; Child mortality ; Clostridium ; Death ; Developing countries ; Fatalities ; Food contamination & poisoning ; Forensic pathology ; Forensic science ; Forensic sciences ; Health care ; Health risks ; Hypotheses ; Illnesses ; Infants ; Infection-related death ; Infections ; Infectious diseases ; Influenza ; LDCs ; Legal medicine ; Medico-legal investigation ; Meningitis ; Mortality ; Mycobacterium tuberculosis ; Pathogens ; Risk analysis ; Risk factors ; Smoke ; Staphylococcus aureus ; Streptococcus infections ; Streptococcus pneumoniae ; SUDA ; SUDI ; Systematic review ; Tobacco ; Tuberculosis ; Viral infections</subject><ispartof>Forensic science international, 2018-08, Vol.289, p.108-119</ispartof><rights>2018 Elsevier B.V.</rights><rights>Copyright © 2018 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier Limited Aug 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-c5ad2ac2d64894f2663eff363ddade760ea09ce52ac218cffe6506453631bd293</citedby><cites>FETCH-LOGICAL-c399t-c5ad2ac2d64894f2663eff363ddade760ea09ce52ac218cffe6506453631bd293</cites><orcidid>0000-0002-4860-9419</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2069740726?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29860163$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kruger, Mia M.</creatorcontrib><creatorcontrib>Martin, Lorna J.</creatorcontrib><creatorcontrib>Maistry, Sairita</creatorcontrib><creatorcontrib>Heathfield, Laura J.</creatorcontrib><title>A systematic review exploring the relationship between infection and sudden unexpected death between 2000 and 2016: A forensic perspective</title><title>Forensic science international</title><addtitle>Forensic Sci Int</addtitle><description>•Forensic autopsies of sudden death cases may reveal infectious cause of death.•Bacterial pathogens were most commonly associated with these deaths.•Risk factors in infants were exposure to tobacco smoke and co-sleeping.•Risk factors in adults were co-morbid conditions and illnesses.•Research in this field is particularly scarce in developing countries.
Death due to infectious diseases is a major health concern worldwide. This is of particular concern in developing countries where poor-socio economic status and a lack of healthcare resources contribute to the high burden of disease. In some cases death due to infection can be acute and aggressive, and death may occur without a diagnosis whilst the person is still alive. These deaths may ultimately lead to a medico-legal autopsy being performed. There are various mechanisms by which sudden death due to infection may occur. In addition, there are many risk factors associated with sudden death due to infection, which differ between infants and older individuals. However, it is unclear which pathogens and risk factors are most frequently associated with sudden death due to infection. Therefore a systematic review of articles and case reports published between 1 January 2000 and 30 June 2016 was undertaken in order to (1) explore the relationship between pathogens and their causative role and (2) identify the relationship between predisposing and/or risk factors associated with sudden death due to infection. Major databases were searched and after critical appraisal 143 articles were identified. It was found that respiratory infections and deaths involving bacterial pathogens were most commonly associated with these deaths. In addition the most common risk factors in infants were exposure to tobacco smoke and co-sleeping. In adults the most common risk factors were co-morbid conditions and illnesses. This information aids in a better understanding of these deaths and highlights the need for more research in this field, particularly in developing countries</description><subject>Acquired immune deficiency syndrome</subject><subject>Adenoviruses</subject><subject>Adults</subject><subject>AIDS</subject><subject>Alcohol</subject><subject>Autopsies</subject><subject>Autopsy</subject><subject>Babies</subject><subject>Case reports</subject><subject>Chicken pox</subject><subject>Child mortality</subject><subject>Clostridium</subject><subject>Death</subject><subject>Developing countries</subject><subject>Fatalities</subject><subject>Food contamination & poisoning</subject><subject>Forensic pathology</subject><subject>Forensic science</subject><subject>Forensic sciences</subject><subject>Health care</subject><subject>Health risks</subject><subject>Hypotheses</subject><subject>Illnesses</subject><subject>Infants</subject><subject>Infection-related 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unexpected death between 2000 and 2016: A forensic perspective</atitle><jtitle>Forensic science international</jtitle><addtitle>Forensic Sci Int</addtitle><date>2018-08-01</date><risdate>2018</risdate><volume>289</volume><spage>108</spage><epage>119</epage><pages>108-119</pages><issn>0379-0738</issn><eissn>1872-6283</eissn><abstract>•Forensic autopsies of sudden death cases may reveal infectious cause of death.•Bacterial pathogens were most commonly associated with these deaths.•Risk factors in infants were exposure to tobacco smoke and co-sleeping.•Risk factors in adults were co-morbid conditions and illnesses.•Research in this field is particularly scarce in developing countries.
Death due to infectious diseases is a major health concern worldwide. This is of particular concern in developing countries where poor-socio economic status and a lack of healthcare resources contribute to the high burden of disease. In some cases death due to infection can be acute and aggressive, and death may occur without a diagnosis whilst the person is still alive. These deaths may ultimately lead to a medico-legal autopsy being performed. There are various mechanisms by which sudden death due to infection may occur. In addition, there are many risk factors associated with sudden death due to infection, which differ between infants and older individuals. However, it is unclear which pathogens and risk factors are most frequently associated with sudden death due to infection. Therefore a systematic review of articles and case reports published between 1 January 2000 and 30 June 2016 was undertaken in order to (1) explore the relationship between pathogens and their causative role and (2) identify the relationship between predisposing and/or risk factors associated with sudden death due to infection. Major databases were searched and after critical appraisal 143 articles were identified. It was found that respiratory infections and deaths involving bacterial pathogens were most commonly associated with these deaths. In addition the most common risk factors in infants were exposure to tobacco smoke and co-sleeping. In adults the most common risk factors were co-morbid conditions and illnesses. This information aids in a better understanding of these deaths and highlights the need for more research in this field, particularly in developing countries</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>29860163</pmid><doi>10.1016/j.forsciint.2018.05.023</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-4860-9419</orcidid></addata></record> |
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| ispartof | Forensic science international, 2018-08, Vol.289, p.108-119 |
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| source | Access via ScienceDirect (Elsevier); ProQuest Central UK/Ireland |
| subjects | Acquired immune deficiency syndrome Adenoviruses Adults AIDS Alcohol Autopsies Autopsy Babies Case reports Chicken pox Child mortality Clostridium Death Developing countries Fatalities Food contamination & poisoning Forensic pathology Forensic science Forensic sciences Health care Health risks Hypotheses Illnesses Infants Infection-related death Infections Infectious diseases Influenza LDCs Legal medicine Medico-legal investigation Meningitis Mortality Mycobacterium tuberculosis Pathogens Risk analysis Risk factors Smoke Staphylococcus aureus Streptococcus infections Streptococcus pneumoniae SUDA SUDI Systematic review Tobacco Tuberculosis Viral infections |
| title | A systematic review exploring the relationship between infection and sudden unexpected death between 2000 and 2016: A forensic perspective |
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