Magterpenoids A–C, Three Polycyclic Meroterpenoids with PTP1B Inhibitory Activity from the Bark of Magnolia officinalis var. biloba

Magterpenoids A–C, Three Polycyclic Meroterpenoids with PTP1B Inhibitory Activity from the Bark of Magnolia officinalis var. biloba

Magterpenoid A (1), possessing a rare 4,6,11-trioxatricyclo­[5.3.1.01,5]­undecane framework with an irregular monoterpenoid moiety, magterpenoid B (2), with an unprecedented 6/6/6/6 polycyclic skeleton, and magterpenoid C (3), a novel terpenoid quinone with a C6–C3 unit, were isolated from the bark...

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Veröffentlicht in:Organic letters 2018-06, Vol.20 (12), p.3682-3686
Hauptverfasser: Li, Chuan, Li, Chuang-Jun, Ma, Jie, Chen, Fang-You, Li, Li, Wang, Xiao-Liang, Ye, Fei, Zhang, Dong-Ming
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container_end_page 3686
container_issue 12
container_start_page 3682
container_title Organic letters
container_volume 20
creator Li, Chuan
Li, Chuang-Jun
Ma, Jie
Chen, Fang-You
Li, Li
Wang, Xiao-Liang
Ye, Fei
Zhang, Dong-Ming
description Magterpenoid A (1), possessing a rare 4,6,11-trioxatricyclo­[5.3.1.01,5]­undecane framework with an irregular monoterpenoid moiety, magterpenoid B (2), with an unprecedented 6/6/6/6 polycyclic skeleton, and magterpenoid C (3), a novel terpenoid quinone with a C6–C3 unit, were isolated from the bark of Magnolia officinalis var. biloba. Plausible biogenetic pathways of 1-3 are presented. Compounds 1 and 3 exhibited significant PTP1B inhibitory activities with IC50 values of 1.44 and 0.81 μM, respectively.
doi_str_mv 10.1021/acs.orglett.8b01476
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title Magterpenoids A–C, Three Polycyclic Meroterpenoids with PTP1B Inhibitory Activity from the Bark of Magnolia officinalis var. biloba
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