Mirilactams C–E, Novel Polycyclic Macrolactams Isolated from Combined-Culture of Actinosynnema mirum NBRC 14064 and Mycolic Acid-Containing Bacterium

Mycolic acid-containing bacteria (MACB) are known to activate cryptic natural product biosynthesis in co-cultures with actinobacteria. We cultured Actinosynnema mirum NBRC 14064, a producer of the mono-cyclic polyene macrolactam mirilactam A (6), with the MACB Tsukamurella pulmonis TP-B0596. As a re...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2018/06/01, Vol.66(6), pp.660-667
Hauptverfasser:	Hoshino, Shotaro, Ozeki, Masahiro, Wong, Chin Piow, Zhang, Huiping, Hayashi, Fumiaki, Awakawa, Takayoshi, Morita, Hiroyuki, Onaka, Hiroyasu, Abe, Ikuro
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinosynnema mirum Bacteria Biosynthesis Chemical compounds Circular dichroism combined-culture Dichroism Epoxidation mycolic acid-containing bacterium NMR Nuclear magnetic resonance Organic chemistry polyene macrolactam
Online-Zugang:	Volltext
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