Anti–Mesothelin Immunotoxin SS1P in Combination with Gemcitabine Results in Increased Activity against Mesothelin-Expressing Tumor Xenografts

Purpose: To determine the antitumor activity of the anti–mesothelin immunotoxin SS1P in combination with gemcitabine against mesothelin-expressing tumor xenografts. Experimental Design: The in vitro activity of SS1P in combination with gemcitabine against the mesothelin-expressing cell line A431/K5...

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Veröffentlicht in:	Clinical cancer research 2007-12, Vol.13 (23), p.7166-7171
Hauptverfasser:	HASSAN, Raffit, COURTNEY BROADDUS, V, WILSON, Shannon, LIEWEHR, David J, JINGLI ZHANG
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - pharmacology Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - pharmacology Apoptosis Biological and medical sciences Cell Line, Tumor Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacology Drug Synergism Female GPI-Linked Proteins Humans Lung cancer Medical sciences Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - immunology Mesothelioma Mice Mice, Nude Neoplasms - drug therapy Neoplasms - immunology Ovarian cancer Pancreatic cancer Pharmacology. Drug treatments Remission Induction Xenograft Model Antitumor Assays
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