Inhibition of inflammation and hyperalgesia in NK-1 receptor knock-out mice

We sought to characterise the contribution of the neuropeptide substance P to the outcome of two models of footpad inflammation of differing severity. In an intense inflammatory model produced by intra-plantar Mycobacterium tuberculosus (10 mg/ml) substantial reductions in footpad swelling, histolog...

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Veröffentlicht in:	Neuroreport 2003-12, Vol.14 (17), p.2189-2192
Hauptverfasser:	Kidd, Bruce L, Inglis, Julia J, Vetsika, Kelly, Hood, Vivienne C, De Felipe, Carmen, Bester, Herve, Hunt, Stephen P, Cruwys, Simon C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthritis, Experimental - chemically induced Arthritis, Experimental - genetics Arthritis, Experimental - prevention & control Female Hyperalgesia - genetics Hyperalgesia - prevention & control Inflammation - genetics Inflammation - prevention & control Male Mice Mice, Knockout Mycobacterium Receptors, Neurokinin-1 - deficiency Receptors, Neurokinin-1 - genetics
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