Intake of phthalates and di(2-ethylhexyl)adipate: Results of the Integrated Exposure Assessment Survey based on duplicate diet samples and biomonitoring data
Phthalates are ubiquitous environmental chemicals with potential detrimental health effects. The purpose of our study was to quantify dietary intake of phthalates and of DEHA (Di-ethylhexyl adipate) using duplicate diet samples and to compare these data with the calculated data based on urinary leve...
Gespeichert in:
| Veröffentlicht in: | Environment international 2007-11, Vol.33 (8), p.1012-1020 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1020 |
|---|---|
| container_issue | 8 |
| container_start_page | 1012 |
| container_title | Environment international |
| container_volume | 33 |
| creator | Fromme, Hermann Gruber, Ludwig Schlummer, Martin Wolz, Gerd Böhmer, Sigrun Angerer, Jürgen Mayer, Richard Liebl, Bernhard Bolte, Gabriele |
| description | Phthalates are ubiquitous environmental chemicals with potential detrimental health effects. The purpose of our study was to quantify dietary intake of phthalates and of DEHA (Di-ethylhexyl adipate) using duplicate diet samples and to compare these data with the calculated data based on urinary levels of primary and secondary phthalate metabolites.
27 female and 23 male healthy subjects aged 14–60 years collected daily duplicate diet samples over 7 consecutive days. Overall, 11 phthalates were measured in the duplicates by GC/MS and LC/MS methods. Urinary levels of primary and secondary phthalate metabolites are also available.
The median (95th percentile) daily intake via food was 2.4 (4.0) μg/kg b.w. (Di-2-ethylhexyl phthalate, DEHP), 0.3 (1.4) μg/kg b.w. (Di-n-butyl phthalate, DnBP), 0.6 (2.1) μg/kg b.w. (Di-isobutyl phthalate, DiBP) and 0.7 (2.2) μg/kg b.w. for DEHA.
MEPH (Mono-2-ethxylhexyl phthalate) was detectable only in minor concentrations in the samples, thus conversion of DEHP to MEHP and dietary intake of MEHP were negligible.
When comparing back-calculated intake data of the DEHP metabolites with dietary DEHP intake from the day before significant correlations were observed for most of the metabolites. No correlation was found for DnBP and only a weak but significant correlation for DiBP.
The median and 95th percentile daily dietary intake of all target analytes did not exceed the recommended tolerable daily intake. Our data indicated that food was the predominant intake source of DEHP, whilst other sources considerably contributed to the daily intake of DnBP and DiBP in an adult population. |
| doi_str_mv | 10.1016/j.envint.2007.05.006 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_20497574</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S016041200700102X</els_id><sourcerecordid>14818529</sourcerecordid><originalsourceid>FETCH-LOGICAL-c452t-468303ed8bd449359cd200a4e0ee3ddd4f5c15aa574dabf7de875378826e20363</originalsourceid><addsrcrecordid>eNqFkc1u1DAUhSMEokPhDRDyBgSLDHZi54cFUlW1UKkSEj9ry7FvGg-JHXydUedheNd6NJG6g9Vd3O-ce3VOlr1mdMsoqz7utuD21sVtQWm9pWJLafUk27CmLvOqFvRptkkYzTkr6Fn2AnFHKS14I55nZ6yuGG1Fucn-3riofgPxPZmHOKhRRUCinCHGvi9yiMNhHOD-MH5Qxs5p-Yl8B1zGiEdJHIAkA7gLaWPI1f3scQlALhABcQIXyY8l7OFAOoUJ8I6YZR6tTng6AJGgmuZxvdhZP3lnow_W3RGjonqZPevViPBqnefZr-urn5df89tvX24uL25zzUURc141JS3BNJ3hvC1Fq00KRXGgAKUxhvdCM6GUqLlRXV8baGpR1k1TVFDQsirPs3cn3zn4PwtglJNFDeOoHPgFZUF5Wyf1f0HGG9aIok0gP4E6eMQAvZyDnVQ4SEblsT-5k6f-5LE_SYVM_SXZm9V_6SYwj6K1sAS8XQGFWo19UE5bfORalgJoj49-PnGQYttbCBK1BafB2AA6SuPtvz95AAUbvdY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>14818529</pqid></control><display><type>article</type><title>Intake of phthalates and di(2-ethylhexyl)adipate: Results of the Integrated Exposure Assessment Survey based on duplicate diet samples and biomonitoring data</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Fromme, Hermann ; Gruber, Ludwig ; Schlummer, Martin ; Wolz, Gerd ; Böhmer, Sigrun ; Angerer, Jürgen ; Mayer, Richard ; Liebl, Bernhard ; Bolte, Gabriele</creator><creatorcontrib>Fromme, Hermann ; Gruber, Ludwig ; Schlummer, Martin ; Wolz, Gerd ; Böhmer, Sigrun ; Angerer, Jürgen ; Mayer, Richard ; Liebl, Bernhard ; Bolte, Gabriele</creatorcontrib><description>Phthalates are ubiquitous environmental chemicals with potential detrimental health effects. The purpose of our study was to quantify dietary intake of phthalates and of DEHA (Di-ethylhexyl adipate) using duplicate diet samples and to compare these data with the calculated data based on urinary levels of primary and secondary phthalate metabolites.
27 female and 23 male healthy subjects aged 14–60 years collected daily duplicate diet samples over 7 consecutive days. Overall, 11 phthalates were measured in the duplicates by GC/MS and LC/MS methods. Urinary levels of primary and secondary phthalate metabolites are also available.
The median (95th percentile) daily intake via food was 2.4 (4.0) μg/kg b.w. (Di-2-ethylhexyl phthalate, DEHP), 0.3 (1.4) μg/kg b.w. (Di-n-butyl phthalate, DnBP), 0.6 (2.1) μg/kg b.w. (Di-isobutyl phthalate, DiBP) and 0.7 (2.2) μg/kg b.w. for DEHA.
MEPH (Mono-2-ethxylhexyl phthalate) was detectable only in minor concentrations in the samples, thus conversion of DEHP to MEHP and dietary intake of MEHP were negligible.
When comparing back-calculated intake data of the DEHP metabolites with dietary DEHP intake from the day before significant correlations were observed for most of the metabolites. No correlation was found for DnBP and only a weak but significant correlation for DiBP.
The median and 95th percentile daily dietary intake of all target analytes did not exceed the recommended tolerable daily intake. Our data indicated that food was the predominant intake source of DEHP, whilst other sources considerably contributed to the daily intake of DnBP and DiBP in an adult population.</description><identifier>ISSN: 0160-4120</identifier><identifier>EISSN: 1873-6750</identifier><identifier>DOI: 10.1016/j.envint.2007.05.006</identifier><identifier>PMID: 17610953</identifier><identifier>CODEN: ENVIDV</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Adipates - analysis ; Adolescent ; Adult ; Biological and medical sciences ; Biomonitoring ; DEHA ; DEHP ; Diet Surveys ; Dietary intake ; DiNP ; DnBP ; Duplicate ; Environmental Monitoring ; Environmental Pollutants - analysis ; Environmental Pollutants - urine ; Female ; Food Contamination - analysis ; Food toxicology ; Germany ; Humans ; Male ; Medical sciences ; MEHP ; Middle Aged ; Phthalates ; Phthalic Acids - analysis ; Phthalic Acids - urine ; Total diet study ; Toxicology</subject><ispartof>Environment international, 2007-11, Vol.33 (8), p.1012-1020</ispartof><rights>2007 Elsevier Ltd</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-468303ed8bd449359cd200a4e0ee3ddd4f5c15aa574dabf7de875378826e20363</citedby><cites>FETCH-LOGICAL-c452t-468303ed8bd449359cd200a4e0ee3ddd4f5c15aa574dabf7de875378826e20363</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.envint.2007.05.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19149394$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17610953$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fromme, Hermann</creatorcontrib><creatorcontrib>Gruber, Ludwig</creatorcontrib><creatorcontrib>Schlummer, Martin</creatorcontrib><creatorcontrib>Wolz, Gerd</creatorcontrib><creatorcontrib>Böhmer, Sigrun</creatorcontrib><creatorcontrib>Angerer, Jürgen</creatorcontrib><creatorcontrib>Mayer, Richard</creatorcontrib><creatorcontrib>Liebl, Bernhard</creatorcontrib><creatorcontrib>Bolte, Gabriele</creatorcontrib><title>Intake of phthalates and di(2-ethylhexyl)adipate: Results of the Integrated Exposure Assessment Survey based on duplicate diet samples and biomonitoring data</title><title>Environment international</title><addtitle>Environ Int</addtitle><description>Phthalates are ubiquitous environmental chemicals with potential detrimental health effects. The purpose of our study was to quantify dietary intake of phthalates and of DEHA (Di-ethylhexyl adipate) using duplicate diet samples and to compare these data with the calculated data based on urinary levels of primary and secondary phthalate metabolites.
27 female and 23 male healthy subjects aged 14–60 years collected daily duplicate diet samples over 7 consecutive days. Overall, 11 phthalates were measured in the duplicates by GC/MS and LC/MS methods. Urinary levels of primary and secondary phthalate metabolites are also available.
The median (95th percentile) daily intake via food was 2.4 (4.0) μg/kg b.w. (Di-2-ethylhexyl phthalate, DEHP), 0.3 (1.4) μg/kg b.w. (Di-n-butyl phthalate, DnBP), 0.6 (2.1) μg/kg b.w. (Di-isobutyl phthalate, DiBP) and 0.7 (2.2) μg/kg b.w. for DEHA.
MEPH (Mono-2-ethxylhexyl phthalate) was detectable only in minor concentrations in the samples, thus conversion of DEHP to MEHP and dietary intake of MEHP were negligible.
When comparing back-calculated intake data of the DEHP metabolites with dietary DEHP intake from the day before significant correlations were observed for most of the metabolites. No correlation was found for DnBP and only a weak but significant correlation for DiBP.
The median and 95th percentile daily dietary intake of all target analytes did not exceed the recommended tolerable daily intake. Our data indicated that food was the predominant intake source of DEHP, whilst other sources considerably contributed to the daily intake of DnBP and DiBP in an adult population.</description><subject>Adipates - analysis</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Biomonitoring</subject><subject>DEHA</subject><subject>DEHP</subject><subject>Diet Surveys</subject><subject>Dietary intake</subject><subject>DiNP</subject><subject>DnBP</subject><subject>Duplicate</subject><subject>Environmental Monitoring</subject><subject>Environmental Pollutants - analysis</subject><subject>Environmental Pollutants - urine</subject><subject>Female</subject><subject>Food Contamination - analysis</subject><subject>Food toxicology</subject><subject>Germany</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>MEHP</subject><subject>Middle Aged</subject><subject>Phthalates</subject><subject>Phthalic Acids - analysis</subject><subject>Phthalic Acids - urine</subject><subject>Total diet study</subject><subject>Toxicology</subject><issn>0160-4120</issn><issn>1873-6750</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhSMEokPhDRDyBgSLDHZi54cFUlW1UKkSEj9ry7FvGg-JHXydUedheNd6NJG6g9Vd3O-ce3VOlr1mdMsoqz7utuD21sVtQWm9pWJLafUk27CmLvOqFvRptkkYzTkr6Fn2AnFHKS14I55nZ6yuGG1Fucn-3riofgPxPZmHOKhRRUCinCHGvi9yiMNhHOD-MH5Qxs5p-Yl8B1zGiEdJHIAkA7gLaWPI1f3scQlALhABcQIXyY8l7OFAOoUJ8I6YZR6tTng6AJGgmuZxvdhZP3lnow_W3RGjonqZPevViPBqnefZr-urn5df89tvX24uL25zzUURc141JS3BNJ3hvC1Fq00KRXGgAKUxhvdCM6GUqLlRXV8baGpR1k1TVFDQsirPs3cn3zn4PwtglJNFDeOoHPgFZUF5Wyf1f0HGG9aIok0gP4E6eMQAvZyDnVQ4SEblsT-5k6f-5LE_SYVM_SXZm9V_6SYwj6K1sAS8XQGFWo19UE5bfORalgJoj49-PnGQYttbCBK1BafB2AA6SuPtvz95AAUbvdY</recordid><startdate>20071101</startdate><enddate>20071101</enddate><creator>Fromme, Hermann</creator><creator>Gruber, Ludwig</creator><creator>Schlummer, Martin</creator><creator>Wolz, Gerd</creator><creator>Böhmer, Sigrun</creator><creator>Angerer, Jürgen</creator><creator>Mayer, Richard</creator><creator>Liebl, Bernhard</creator><creator>Bolte, Gabriele</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7T2</scope><scope>7TV</scope><scope>7U2</scope><scope>7U7</scope></search><sort><creationdate>20071101</creationdate><title>Intake of phthalates and di(2-ethylhexyl)adipate: Results of the Integrated Exposure Assessment Survey based on duplicate diet samples and biomonitoring data</title><author>Fromme, Hermann ; Gruber, Ludwig ; Schlummer, Martin ; Wolz, Gerd ; Böhmer, Sigrun ; Angerer, Jürgen ; Mayer, Richard ; Liebl, Bernhard ; Bolte, Gabriele</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-468303ed8bd449359cd200a4e0ee3ddd4f5c15aa574dabf7de875378826e20363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adipates - analysis</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Biomonitoring</topic><topic>DEHA</topic><topic>DEHP</topic><topic>Diet Surveys</topic><topic>Dietary intake</topic><topic>DiNP</topic><topic>DnBP</topic><topic>Duplicate</topic><topic>Environmental Monitoring</topic><topic>Environmental Pollutants - analysis</topic><topic>Environmental Pollutants - urine</topic><topic>Female</topic><topic>Food Contamination - analysis</topic><topic>Food toxicology</topic><topic>Germany</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>MEHP</topic><topic>Middle Aged</topic><topic>Phthalates</topic><topic>Phthalic Acids - analysis</topic><topic>Phthalic Acids - urine</topic><topic>Total diet study</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fromme, Hermann</creatorcontrib><creatorcontrib>Gruber, Ludwig</creatorcontrib><creatorcontrib>Schlummer, Martin</creatorcontrib><creatorcontrib>Wolz, Gerd</creatorcontrib><creatorcontrib>Böhmer, Sigrun</creatorcontrib><creatorcontrib>Angerer, Jürgen</creatorcontrib><creatorcontrib>Mayer, Richard</creatorcontrib><creatorcontrib>Liebl, Bernhard</creatorcontrib><creatorcontrib>Bolte, Gabriele</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Pollution Abstracts</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><jtitle>Environment international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fromme, Hermann</au><au>Gruber, Ludwig</au><au>Schlummer, Martin</au><au>Wolz, Gerd</au><au>Böhmer, Sigrun</au><au>Angerer, Jürgen</au><au>Mayer, Richard</au><au>Liebl, Bernhard</au><au>Bolte, Gabriele</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intake of phthalates and di(2-ethylhexyl)adipate: Results of the Integrated Exposure Assessment Survey based on duplicate diet samples and biomonitoring data</atitle><jtitle>Environment international</jtitle><addtitle>Environ Int</addtitle><date>2007-11-01</date><risdate>2007</risdate><volume>33</volume><issue>8</issue><spage>1012</spage><epage>1020</epage><pages>1012-1020</pages><issn>0160-4120</issn><eissn>1873-6750</eissn><coden>ENVIDV</coden><abstract>Phthalates are ubiquitous environmental chemicals with potential detrimental health effects. The purpose of our study was to quantify dietary intake of phthalates and of DEHA (Di-ethylhexyl adipate) using duplicate diet samples and to compare these data with the calculated data based on urinary levels of primary and secondary phthalate metabolites.
27 female and 23 male healthy subjects aged 14–60 years collected daily duplicate diet samples over 7 consecutive days. Overall, 11 phthalates were measured in the duplicates by GC/MS and LC/MS methods. Urinary levels of primary and secondary phthalate metabolites are also available.
The median (95th percentile) daily intake via food was 2.4 (4.0) μg/kg b.w. (Di-2-ethylhexyl phthalate, DEHP), 0.3 (1.4) μg/kg b.w. (Di-n-butyl phthalate, DnBP), 0.6 (2.1) μg/kg b.w. (Di-isobutyl phthalate, DiBP) and 0.7 (2.2) μg/kg b.w. for DEHA.
MEPH (Mono-2-ethxylhexyl phthalate) was detectable only in minor concentrations in the samples, thus conversion of DEHP to MEHP and dietary intake of MEHP were negligible.
When comparing back-calculated intake data of the DEHP metabolites with dietary DEHP intake from the day before significant correlations were observed for most of the metabolites. No correlation was found for DnBP and only a weak but significant correlation for DiBP.
The median and 95th percentile daily dietary intake of all target analytes did not exceed the recommended tolerable daily intake. Our data indicated that food was the predominant intake source of DEHP, whilst other sources considerably contributed to the daily intake of DnBP and DiBP in an adult population.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>17610953</pmid><doi>10.1016/j.envint.2007.05.006</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0160-4120 |
| ispartof | Environment international, 2007-11, Vol.33 (8), p.1012-1020 |
| issn | 0160-4120 1873-6750 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_20497574 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adipates - analysis Adolescent Adult Biological and medical sciences Biomonitoring DEHA DEHP Diet Surveys Dietary intake DiNP DnBP Duplicate Environmental Monitoring Environmental Pollutants - analysis Environmental Pollutants - urine Female Food Contamination - analysis Food toxicology Germany Humans Male Medical sciences MEHP Middle Aged Phthalates Phthalic Acids - analysis Phthalic Acids - urine Total diet study Toxicology |
| title | Intake of phthalates and di(2-ethylhexyl)adipate: Results of the Integrated Exposure Assessment Survey based on duplicate diet samples and biomonitoring data |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-17T11%3A05%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Intake%20of%20phthalates%20and%20di(2-ethylhexyl)adipate:%20Results%20of%20the%20Integrated%20Exposure%20Assessment%20Survey%20based%20on%20duplicate%20diet%20samples%20and%20biomonitoring%20data&rft.jtitle=Environment%20international&rft.au=Fromme,%20Hermann&rft.date=2007-11-01&rft.volume=33&rft.issue=8&rft.spage=1012&rft.epage=1020&rft.pages=1012-1020&rft.issn=0160-4120&rft.eissn=1873-6750&rft.coden=ENVIDV&rft_id=info:doi/10.1016/j.envint.2007.05.006&rft_dat=%3Cproquest_cross%3E14818529%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=14818529&rft_id=info:pmid/17610953&rft_els_id=S016041200700102X&rfr_iscdi=true |