Chronic activity wheel running reduces the severity of kainic acid-induced seizures in the rat: Possible role of galanin

Abstract Studies in both humans and rodents suggest that exercise can be neuroprotective, but the mechanisms by which this occurs are still poorly understood. Three weeks of voluntary, physical activity in rats upregulates prepro-galanin messenger RNA levels in the locus coeruleus. Galanin is a neur...

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Veröffentlicht in:	Brain research 2009-04, Vol.1266, p.54-63
Hauptverfasser:	Reiss, J.I, Dishman, R.K, Boyd, H.E, Robinson, J.K, Holmes, P.V
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Autoradiography Biological and medical sciences Catheterization Convulsant Dose-Response Relationship, Drug Excitotoxicity Exercise Galanin Galanin - administration & dosage Galanin - antagonists & inhibitors Galanin - metabolism Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Hippocampus - drug effects Hippocampus - physiopathology In Situ Hybridization Injections, Intraperitoneal Injections, Intraventricular Kainic Acid Male Medical sciences Motor Activity Nervous system (semeiology, syndromes) Neurology Neuroprotection Peptide Fragments - administration & dosage Physical Conditioning, Animal - physiology Proto-Oncogene Proteins c-fos - metabolism Rats Rats, Sprague-Dawley RNA, Messenger - metabolism Seizures - chemically induced Seizures - physiopathology
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