Topical instillation of ciliary neurotrophic factor inhibits retinal degeneration in streptozotocin-induced diabetic rats

Intraocular injections of ciliary neurotrophic factor (CNTF) or intraocular adenovirus-mediated CNTF gene transfer have been reported to inhibit retinal alterations in inherited retinal degeneration in mice strains. To investigate whether or not CNTF administered by eye drops prevents retinal degene...

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Veröffentlicht in:	Neuroreport 2003-11, Vol.14 (16), p.2067-2071
Hauptverfasser:	Aizu, Yoshinori, Katayama, Hiroyuki, Takahama, Sachiko, Hu, Jianguo, Nakagawa, Hachiro, Oyanagi, Kiyomitsu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atrophy - drug therapy Atrophy - physiopathology Atrophy - prevention & control Biological and medical sciences Blood Glucose Cell Death - drug effects Cell Death - physiology Ciliary Neurotrophic Factor - administration & dosage Ciliary Neurotrophic Factor - therapeutic use Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - complications Diabetes. Impaired glucose tolerance Electroretinography - drug effects Endocrine pancreas. Apud cells (diseases) Endocrinopathies Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Instillation, Drug Male Medical sciences Nerve Degeneration - etiology Nerve Degeneration - physiopathology Nerve Degeneration - prevention & control Neurons - drug effects Neurons - pathology Pigment Epithelium of Eye - drug effects Pigment Epithelium of Eye - pathology Pigment Epithelium of Eye - physiopathology Rats Recombinant Proteins - administration & dosage Recombinant Proteins - therapeutic use Retinal Degeneration - etiology Retinal Degeneration - physiopathology Retinal Degeneration - prevention & control Treatment Outcome Vertebrates: nervous system and sense organs
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