Topical instillation of ciliary neurotrophic factor inhibits retinal degeneration in streptozotocin-induced diabetic rats
Intraocular injections of ciliary neurotrophic factor (CNTF) or intraocular adenovirus-mediated CNTF gene transfer have been reported to inhibit retinal alterations in inherited retinal degeneration in mice strains. To investigate whether or not CNTF administered by eye drops prevents retinal degene...
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| Veröffentlicht in: | Neuroreport 2003-11, Vol.14 (16), p.2067-2071 |
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| creator | Aizu, Yoshinori Katayama, Hiroyuki Takahama, Sachiko Hu, Jianguo Nakagawa, Hachiro Oyanagi, Kiyomitsu |
| description | Intraocular injections of ciliary neurotrophic factor (CNTF) or intraocular adenovirus-mediated CNTF gene transfer have been reported to inhibit retinal alterations in inherited retinal degeneration in mice strains. To investigate whether or not CNTF administered by eye drops prevents retinal degeneration in streptozotocin (STZ)-induced diabetic rats, recombinant CNTF was administered to eyes of diabetic rats (n=20) twice daily for 1 month after the onset of diabetes. The b-wave amplitude of electroretinogram in CNTF-administered diabetic rats was significantly larger than that of diabetic rats, and approached that of the controls. Atrophy of the inner plexiform layer, and cavity formation in the pigment epithelium, which were observed in diabetic rats, were prevented in CNTF-administered diabetic rats. These results indicate that CNTF administration by eye drops prevents retinal degeneration in STZ-induced diabetic rats. |
| doi_str_mv | 10.1097/00001756-200311140-00012 |
| format | Article |
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To investigate whether or not CNTF administered by eye drops prevents retinal degeneration in streptozotocin (STZ)-induced diabetic rats, recombinant CNTF was administered to eyes of diabetic rats (n=20) twice daily for 1 month after the onset of diabetes. The b-wave amplitude of electroretinogram in CNTF-administered diabetic rats was significantly larger than that of diabetic rats, and approached that of the controls. Atrophy of the inner plexiform layer, and cavity formation in the pigment epithelium, which were observed in diabetic rats, were prevented in CNTF-administered diabetic rats. These results indicate that CNTF administration by eye drops prevents retinal degeneration in STZ-induced diabetic rats.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/00001756-200311140-00012</identifier><identifier>PMID: 14600499</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Animals ; Atrophy - drug therapy ; Atrophy - physiopathology ; Atrophy - prevention & control ; Biological and medical sciences ; Blood Glucose ; Cell Death - drug effects ; Cell Death - physiology ; Ciliary Neurotrophic Factor - administration & dosage ; Ciliary Neurotrophic Factor - therapeutic use ; Diabetes Mellitus, Experimental - chemically induced ; Diabetes Mellitus, Experimental - complications ; Diabetes. Impaired glucose tolerance ; Electroretinography - drug effects ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Eye and associated structures. Visual pathways and centers. Vision ; Fundamental and applied biological sciences. Psychology ; Instillation, Drug ; Male ; Medical sciences ; Nerve Degeneration - etiology ; Nerve Degeneration - physiopathology ; Nerve Degeneration - prevention & control ; Neurons - drug effects ; Neurons - pathology ; Pigment Epithelium of Eye - drug effects ; Pigment Epithelium of Eye - pathology ; Pigment Epithelium of Eye - physiopathology ; Rats ; Recombinant Proteins - administration & dosage ; Recombinant Proteins - therapeutic use ; Retinal Degeneration - etiology ; Retinal Degeneration - physiopathology ; Retinal Degeneration - prevention & control ; Treatment Outcome ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroreport, 2003-11, Vol.14 (16), p.2067-2071</ispartof><rights>2003 Lippincott Williams & Wilkins, Inc.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4512-e8e71ad1474e6dc68c708b34adc6e3a15eae4e876af89318f9d9326bc38e69283</citedby><cites>FETCH-LOGICAL-c4512-e8e71ad1474e6dc68c708b34adc6e3a15eae4e876af89318f9d9326bc38e69283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15898512$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14600499$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aizu, Yoshinori</creatorcontrib><creatorcontrib>Katayama, Hiroyuki</creatorcontrib><creatorcontrib>Takahama, Sachiko</creatorcontrib><creatorcontrib>Hu, Jianguo</creatorcontrib><creatorcontrib>Nakagawa, Hachiro</creatorcontrib><creatorcontrib>Oyanagi, Kiyomitsu</creatorcontrib><title>Topical instillation of ciliary neurotrophic factor inhibits retinal degeneration in streptozotocin-induced diabetic rats</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>Intraocular injections of ciliary neurotrophic factor (CNTF) or intraocular adenovirus-mediated CNTF gene transfer have been reported to inhibit retinal alterations in inherited retinal degeneration in mice strains. 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Visual pathways and centers. Vision</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Instillation, Drug</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nerve Degeneration - etiology</subject><subject>Nerve Degeneration - physiopathology</subject><subject>Nerve Degeneration - prevention & control</subject><subject>Neurons - drug effects</subject><subject>Neurons - pathology</subject><subject>Pigment Epithelium of Eye - drug effects</subject><subject>Pigment Epithelium of Eye - pathology</subject><subject>Pigment Epithelium of Eye - physiopathology</subject><subject>Rats</subject><subject>Recombinant Proteins - administration & dosage</subject><subject>Recombinant Proteins - therapeutic use</subject><subject>Retinal Degeneration - etiology</subject><subject>Retinal Degeneration - physiopathology</subject><subject>Retinal Degeneration - prevention & control</subject><subject>Treatment Outcome</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1v1DAQhi0EotvCX0C-wC1gxx-xj6jiS6rEpUjcLMeZsANZO9iOqvLrcbtLe8KXsaznHWueIYRy9pYzO7xj7fBB6a5nTHDOJevuXvonZMflIDqlzPenZMessp20Wp2R81J-NsQybp6TMy41Y9LaHbm9TisGv1CMpeKy-Iop0jTTgAv6fEsjbDnVnNY9Bjr7UFNu7B5HrIVmqBhbeIIfECEfwxhpqRnWmv6kmgLGDuO0BZjohH5siUAbWV6QZ7NfCrw81Qvy7eOH68vP3dXXT18u3191QSred2Bg4H5qY0nQU9AmDMyMQvp2B-G5Ag8SzKD9bKzgZraTFb0egzCgbW_EBXlz7Lvm9HuDUt0BS4A2aoS0Fdc3Edoy2UBzBENOpWSY3Zrx0Bw4ztyddvdPu3vQ7u61t-ir0x_beIDpMXjy3IDXJ8CXZnvOPgYsj5wy1qj7RvLI3aSlQi6_lu0GstuDX-re_W_t4i-YKp1k</recordid><startdate>20031114</startdate><enddate>20031114</enddate><creator>Aizu, Yoshinori</creator><creator>Katayama, Hiroyuki</creator><creator>Takahama, Sachiko</creator><creator>Hu, Jianguo</creator><creator>Nakagawa, Hachiro</creator><creator>Oyanagi, Kiyomitsu</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>20031114</creationdate><title>Topical instillation of ciliary neurotrophic factor inhibits retinal degeneration in streptozotocin-induced diabetic rats</title><author>Aizu, Yoshinori ; Katayama, Hiroyuki ; Takahama, Sachiko ; Hu, Jianguo ; Nakagawa, Hachiro ; Oyanagi, Kiyomitsu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4512-e8e71ad1474e6dc68c708b34adc6e3a15eae4e876af89318f9d9326bc38e69283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Atrophy - drug therapy</topic><topic>Atrophy - physiopathology</topic><topic>Atrophy - prevention & control</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose</topic><topic>Cell Death - drug effects</topic><topic>Cell Death - physiology</topic><topic>Ciliary Neurotrophic Factor - administration & dosage</topic><topic>Ciliary Neurotrophic Factor - therapeutic use</topic><topic>Diabetes Mellitus, Experimental - chemically induced</topic><topic>Diabetes Mellitus, Experimental - complications</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Electroretinography - drug effects</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>Fundamental and applied biological sciences. 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To investigate whether or not CNTF administered by eye drops prevents retinal degeneration in streptozotocin (STZ)-induced diabetic rats, recombinant CNTF was administered to eyes of diabetic rats (n=20) twice daily for 1 month after the onset of diabetes. The b-wave amplitude of electroretinogram in CNTF-administered diabetic rats was significantly larger than that of diabetic rats, and approached that of the controls. Atrophy of the inner plexiform layer, and cavity formation in the pigment epithelium, which were observed in diabetic rats, were prevented in CNTF-administered diabetic rats. These results indicate that CNTF administration by eye drops prevents retinal degeneration in STZ-induced diabetic rats.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>14600499</pmid><doi>10.1097/00001756-200311140-00012</doi><tpages>5</tpages></addata></record> |
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| subjects | Animals Atrophy - drug therapy Atrophy - physiopathology Atrophy - prevention & control Biological and medical sciences Blood Glucose Cell Death - drug effects Cell Death - physiology Ciliary Neurotrophic Factor - administration & dosage Ciliary Neurotrophic Factor - therapeutic use Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - complications Diabetes. Impaired glucose tolerance Electroretinography - drug effects Endocrine pancreas. Apud cells (diseases) Endocrinopathies Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Instillation, Drug Male Medical sciences Nerve Degeneration - etiology Nerve Degeneration - physiopathology Nerve Degeneration - prevention & control Neurons - drug effects Neurons - pathology Pigment Epithelium of Eye - drug effects Pigment Epithelium of Eye - pathology Pigment Epithelium of Eye - physiopathology Rats Recombinant Proteins - administration & dosage Recombinant Proteins - therapeutic use Retinal Degeneration - etiology Retinal Degeneration - physiopathology Retinal Degeneration - prevention & control Treatment Outcome Vertebrates: nervous system and sense organs |
| title | Topical instillation of ciliary neurotrophic factor inhibits retinal degeneration in streptozotocin-induced diabetic rats |
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