Asthma and its comorbidities in middle-aged and older adults; the Rotterdam Study
Little is known on the prevalence and characteristics of asthma in middle-aged and older adults, since previous studies mainly focused on children and young adults. Therefore, the aim was to investigate the prevalence of physician-diagnosed asthma and its comorbidities, in a population-based cohort...
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| Veröffentlicht in: | Respiratory medicine 2018-06, Vol.139, p.6-12 |
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| creator | de Roos, Emmely W. Lahousse, Lies Verhamme, Katia M.C. Braunstahl, Gert-Jan Ikram, M. Arfan in ‘t Veen, Johannes C.C.M. Stricker, Bruno H.Ch Brusselle, Guy G.O. |
| description | Little is known on the prevalence and characteristics of asthma in middle-aged and older adults, since previous studies mainly focused on children and young adults. Therefore, the aim was to investigate the prevalence of physician-diagnosed asthma and its comorbidities, in a population-based cohort of adults 45 years of age and over.
We identified participants with physician-diagnosed asthma in the Rotterdam Study; a prospective population-based cohort in the Netherlands. Pulmonary function measurements and comorbidities of the asthma cases were assessed at baseline and compared to those of the general population.
Out of 14,621 participants (mean age 65.5 years; 59% women), 524 subjects (31.5%males) had physician-diagnosed asthma at study entry, implicating an asthma prevalence of 3.6% [95% Confidence Interval (CI) 3.3%–3.9%] (2.8% in males and 4.2% in females). Asthmatic subjects had a significantly higher prevalence of obesity and depressive symptoms (Odds Ratio [OR]: 2,02 [95% CI 1,66-2,47] and [OR]: 2,01 [95% CI 1,52-2,66] respectively). Longer duration of asthma and current smoking were associated with lower lung function in asthmatic subjects.
Four percent of middle-aged and older adults have physician-diagnosed asthma. These adult asthmatics suffer more frequently from obesity and depression than subjects without obstructive lung disease.
•At least 3,6% of adults over 45 years is diagnosed with asthma.•Asthma in older adults is strongly associated with obesity and depression.•Asthmatics have significantly lower lungfunction compared to the general population. |
| doi_str_mv | 10.1016/j.rmed.2018.04.006 |
| format | Article |
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We identified participants with physician-diagnosed asthma in the Rotterdam Study; a prospective population-based cohort in the Netherlands. Pulmonary function measurements and comorbidities of the asthma cases were assessed at baseline and compared to those of the general population.
Out of 14,621 participants (mean age 65.5 years; 59% women), 524 subjects (31.5%males) had physician-diagnosed asthma at study entry, implicating an asthma prevalence of 3.6% [95% Confidence Interval (CI) 3.3%–3.9%] (2.8% in males and 4.2% in females). Asthmatic subjects had a significantly higher prevalence of obesity and depressive symptoms (Odds Ratio [OR]: 2,02 [95% CI 1,66-2,47] and [OR]: 2,01 [95% CI 1,52-2,66] respectively). Longer duration of asthma and current smoking were associated with lower lung function in asthmatic subjects.
Four percent of middle-aged and older adults have physician-diagnosed asthma. These adult asthmatics suffer more frequently from obesity and depression than subjects without obstructive lung disease.
•At least 3,6% of adults over 45 years is diagnosed with asthma.•Asthma in older adults is strongly associated with obesity and depression.•Asthmatics have significantly lower lungfunction compared to the general population.</description><identifier>ISSN: 0954-6111</identifier><identifier>EISSN: 1532-3064</identifier><identifier>DOI: 10.1016/j.rmed.2018.04.006</identifier><identifier>PMID: 29858003</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adults ; Age groups ; Aged ; Aged, 80 and over ; Airway management ; Asthma ; Asthma - epidemiology ; Asthma - physiopathology ; Body mass index ; Children ; Chronic obstructive pulmonary disease ; Comorbidity ; Confidence intervals ; Depression - epidemiology ; Diabetes ; Ethnicity ; Female ; Females ; General population ; Heart attacks ; Heart failure ; Humans ; Hypertension ; Identification methods ; Lung diseases ; Male ; Males ; Mental depression ; Middle age ; Middle Aged ; Netherlands - epidemiology ; Obesity ; Obesity - epidemiology ; Obstructive lung disease ; Odds Ratio ; Older adults ; Older people ; Patient admissions ; Population ; Population studies ; Prevalence ; Prospective Studies ; Pulmonary functions ; Questionnaires ; Respiratory function ; Respiratory Function Tests ; Smoking ; Smoking - adverse effects ; Smoking - epidemiology ; Young adults</subject><ispartof>Respiratory medicine, 2018-06, Vol.139, p.6-12</ispartof><rights>2018 Elsevier Ltd</rights><rights>Copyright © 2018 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Jun 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-58b0e8d39df97f17f4f7d349a26de870dbcb2bcd643f63e1466da231302da1123</citedby><cites>FETCH-LOGICAL-c428t-58b0e8d39df97f17f4f7d349a26de870dbcb2bcd643f63e1466da231302da1123</cites><orcidid>0000-0002-3494-4363 ; 0000-0003-1683-7211</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0954611118301148$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29858003$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Roos, Emmely W.</creatorcontrib><creatorcontrib>Lahousse, Lies</creatorcontrib><creatorcontrib>Verhamme, Katia M.C.</creatorcontrib><creatorcontrib>Braunstahl, Gert-Jan</creatorcontrib><creatorcontrib>Ikram, M. Arfan</creatorcontrib><creatorcontrib>in ‘t Veen, Johannes C.C.M.</creatorcontrib><creatorcontrib>Stricker, Bruno H.Ch</creatorcontrib><creatorcontrib>Brusselle, Guy G.O.</creatorcontrib><title>Asthma and its comorbidities in middle-aged and older adults; the Rotterdam Study</title><title>Respiratory medicine</title><addtitle>Respir Med</addtitle><description>Little is known on the prevalence and characteristics of asthma in middle-aged and older adults, since previous studies mainly focused on children and young adults. Therefore, the aim was to investigate the prevalence of physician-diagnosed asthma and its comorbidities, in a population-based cohort of adults 45 years of age and over.
We identified participants with physician-diagnosed asthma in the Rotterdam Study; a prospective population-based cohort in the Netherlands. Pulmonary function measurements and comorbidities of the asthma cases were assessed at baseline and compared to those of the general population.
Out of 14,621 participants (mean age 65.5 years; 59% women), 524 subjects (31.5%males) had physician-diagnosed asthma at study entry, implicating an asthma prevalence of 3.6% [95% Confidence Interval (CI) 3.3%–3.9%] (2.8% in males and 4.2% in females). Asthmatic subjects had a significantly higher prevalence of obesity and depressive symptoms (Odds Ratio [OR]: 2,02 [95% CI 1,66-2,47] and [OR]: 2,01 [95% CI 1,52-2,66] respectively). Longer duration of asthma and current smoking were associated with lower lung function in asthmatic subjects.
Four percent of middle-aged and older adults have physician-diagnosed asthma. These adult asthmatics suffer more frequently from obesity and depression than subjects without obstructive lung disease.
•At least 3,6% of adults over 45 years is diagnosed with asthma.•Asthma in older adults is strongly associated with obesity and depression.•Asthmatics have significantly lower lungfunction compared to the general population.</description><subject>Adults</subject><subject>Age groups</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Airway management</subject><subject>Asthma</subject><subject>Asthma - epidemiology</subject><subject>Asthma - physiopathology</subject><subject>Body mass index</subject><subject>Children</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Comorbidity</subject><subject>Confidence intervals</subject><subject>Depression - epidemiology</subject><subject>Diabetes</subject><subject>Ethnicity</subject><subject>Female</subject><subject>Females</subject><subject>General population</subject><subject>Heart attacks</subject><subject>Heart failure</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Identification methods</subject><subject>Lung diseases</subject><subject>Male</subject><subject>Males</subject><subject>Mental depression</subject><subject>Middle age</subject><subject>Middle Aged</subject><subject>Netherlands - epidemiology</subject><subject>Obesity</subject><subject>Obesity - epidemiology</subject><subject>Obstructive lung disease</subject><subject>Odds Ratio</subject><subject>Older adults</subject><subject>Older people</subject><subject>Patient admissions</subject><subject>Population</subject><subject>Population studies</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Pulmonary functions</subject><subject>Questionnaires</subject><subject>Respiratory function</subject><subject>Respiratory Function Tests</subject><subject>Smoking</subject><subject>Smoking - adverse effects</subject><subject>Smoking - epidemiology</subject><subject>Young adults</subject><issn>0954-6111</issn><issn>1532-3064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtv1TAQhS0EopfCH2CBLLFhkzB-xEkEm6riJVVCvNaW45lQXyVxsR2k_nsSbrthwWoW5ztHo4-x5wJqAcK8PtZpJqwliK4GXQOYB-wgGiUrBUY_ZAfoG10ZIcQZe5LzEQB6reExO5N913QA6sC-XORyPTvuFuShZO7jHNMQMJRAmYeFzwFxosr9JPwLxQkpcYfrVPIbXq6Jf42lUEI3829lxdun7NHopkzP7u45-_H-3ffLj9XV5w-fLi-uKq9lV6qmG4A6VD2OfTuKdtRji0r3ThqkrgUc_CAHj0ar0SgS2hh0UgkFEp0QUp2zV6fdmxR_rZSLnUP2NE1uobhmK0H3jZEN9Bv68h_0GNe0bN_tlGl0K0y7UfJE-RRzTjTamxRml26tALsLt0e7C7e7cAvabsK30ou76XXYs_vKveENeHsCaHPxO1Cy2QdaPGFI5IvFGP63_wcH5ZBV</recordid><startdate>201806</startdate><enddate>201806</enddate><creator>de Roos, Emmely W.</creator><creator>Lahousse, Lies</creator><creator>Verhamme, Katia M.C.</creator><creator>Braunstahl, Gert-Jan</creator><creator>Ikram, M. Arfan</creator><creator>in ‘t Veen, Johannes C.C.M.</creator><creator>Stricker, Bruno H.Ch</creator><creator>Brusselle, Guy G.O.</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>ASE</scope><scope>FPQ</scope><scope>H94</scope><scope>K6X</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3494-4363</orcidid><orcidid>https://orcid.org/0000-0003-1683-7211</orcidid></search><sort><creationdate>201806</creationdate><title>Asthma and its comorbidities in middle-aged and older adults; the Rotterdam Study</title><author>de Roos, Emmely W. ; Lahousse, Lies ; Verhamme, Katia M.C. ; Braunstahl, Gert-Jan ; Ikram, M. Arfan ; in ‘t Veen, Johannes C.C.M. ; Stricker, Bruno H.Ch ; Brusselle, Guy G.O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-58b0e8d39df97f17f4f7d349a26de870dbcb2bcd643f63e1466da231302da1123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adults</topic><topic>Age groups</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Airway management</topic><topic>Asthma</topic><topic>Asthma - epidemiology</topic><topic>Asthma - physiopathology</topic><topic>Body mass index</topic><topic>Children</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Comorbidity</topic><topic>Confidence intervals</topic><topic>Depression - epidemiology</topic><topic>Diabetes</topic><topic>Ethnicity</topic><topic>Female</topic><topic>Females</topic><topic>General population</topic><topic>Heart attacks</topic><topic>Heart failure</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Identification methods</topic><topic>Lung diseases</topic><topic>Male</topic><topic>Males</topic><topic>Mental depression</topic><topic>Middle age</topic><topic>Middle Aged</topic><topic>Netherlands - epidemiology</topic><topic>Obesity</topic><topic>Obesity - epidemiology</topic><topic>Obstructive lung disease</topic><topic>Odds Ratio</topic><topic>Older adults</topic><topic>Older people</topic><topic>Patient admissions</topic><topic>Population</topic><topic>Population studies</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>Pulmonary functions</topic><topic>Questionnaires</topic><topic>Respiratory function</topic><topic>Respiratory Function Tests</topic><topic>Smoking</topic><topic>Smoking - adverse effects</topic><topic>Smoking - epidemiology</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Roos, Emmely W.</creatorcontrib><creatorcontrib>Lahousse, Lies</creatorcontrib><creatorcontrib>Verhamme, Katia M.C.</creatorcontrib><creatorcontrib>Braunstahl, Gert-Jan</creatorcontrib><creatorcontrib>Ikram, M. Arfan</creatorcontrib><creatorcontrib>in ‘t Veen, Johannes C.C.M.</creatorcontrib><creatorcontrib>Stricker, Bruno H.Ch</creatorcontrib><creatorcontrib>Brusselle, Guy G.O.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Respiratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Roos, Emmely W.</au><au>Lahousse, Lies</au><au>Verhamme, Katia M.C.</au><au>Braunstahl, Gert-Jan</au><au>Ikram, M. Arfan</au><au>in ‘t Veen, Johannes C.C.M.</au><au>Stricker, Bruno H.Ch</au><au>Brusselle, Guy G.O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Asthma and its comorbidities in middle-aged and older adults; the Rotterdam Study</atitle><jtitle>Respiratory medicine</jtitle><addtitle>Respir Med</addtitle><date>2018-06</date><risdate>2018</risdate><volume>139</volume><spage>6</spage><epage>12</epage><pages>6-12</pages><issn>0954-6111</issn><eissn>1532-3064</eissn><abstract>Little is known on the prevalence and characteristics of asthma in middle-aged and older adults, since previous studies mainly focused on children and young adults. Therefore, the aim was to investigate the prevalence of physician-diagnosed asthma and its comorbidities, in a population-based cohort of adults 45 years of age and over.
We identified participants with physician-diagnosed asthma in the Rotterdam Study; a prospective population-based cohort in the Netherlands. Pulmonary function measurements and comorbidities of the asthma cases were assessed at baseline and compared to those of the general population.
Out of 14,621 participants (mean age 65.5 years; 59% women), 524 subjects (31.5%males) had physician-diagnosed asthma at study entry, implicating an asthma prevalence of 3.6% [95% Confidence Interval (CI) 3.3%–3.9%] (2.8% in males and 4.2% in females). Asthmatic subjects had a significantly higher prevalence of obesity and depressive symptoms (Odds Ratio [OR]: 2,02 [95% CI 1,66-2,47] and [OR]: 2,01 [95% CI 1,52-2,66] respectively). Longer duration of asthma and current smoking were associated with lower lung function in asthmatic subjects.
Four percent of middle-aged and older adults have physician-diagnosed asthma. These adult asthmatics suffer more frequently from obesity and depression than subjects without obstructive lung disease.
•At least 3,6% of adults over 45 years is diagnosed with asthma.•Asthma in older adults is strongly associated with obesity and depression.•Asthmatics have significantly lower lungfunction compared to the general population.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>29858003</pmid><doi>10.1016/j.rmed.2018.04.006</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-3494-4363</orcidid><orcidid>https://orcid.org/0000-0003-1683-7211</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adults Age groups Aged Aged, 80 and over Airway management Asthma Asthma - epidemiology Asthma - physiopathology Body mass index Children Chronic obstructive pulmonary disease Comorbidity Confidence intervals Depression - epidemiology Diabetes Ethnicity Female Females General population Heart attacks Heart failure Humans Hypertension Identification methods Lung diseases Male Males Mental depression Middle age Middle Aged Netherlands - epidemiology Obesity Obesity - epidemiology Obstructive lung disease Odds Ratio Older adults Older people Patient admissions Population Population studies Prevalence Prospective Studies Pulmonary functions Questionnaires Respiratory function Respiratory Function Tests Smoking Smoking - adverse effects Smoking - epidemiology Young adults |
| title | Asthma and its comorbidities in middle-aged and older adults; the Rotterdam Study |
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