Prognostic impact of the integration of volumetric quantification of the solid part of the tumor on 3DCT and FDG-PET imaging in clinical stage IA adenocarcinoma of the lung
•Solid-part volume of lung adenocarcinoma is a powerful predictor of prognosis.•The integration of solid-part volume and SUVmax of FDG is also highly useful.•Three-dimensional lung tumor analysis is beneficial for understanding lung cancer biology. The aim of this study was to conduct comparative an...
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| Veröffentlicht in: | Lung cancer (Amsterdam, Netherlands) Netherlands), 2018-07, Vol.121, p.91-96 |
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| creator | Furumoto, Hideyuki Shimada, Yoshihisa Imai, Kentaro Maehara, Sachio Maeda, Junichi Hagiwara, Masaru Okano, Tetsuya Masuno, Ryuhei Kakihana, Masatoshi Kajiwara, Naohiro Ohira, Tatsuo Ikeda, Norihiko |
| description | •Solid-part volume of lung adenocarcinoma is a powerful predictor of prognosis.•The integration of solid-part volume and SUVmax of FDG is also highly useful.•Three-dimensional lung tumor analysis is beneficial for understanding lung cancer biology.
The aim of this study was to conduct comparative analyses of the biological malignant potential of clinical stage IA adenocarcinoma using positron emission tomography/computed tomography (PET/CT), high-resolution CT (HRCT), and three-dimensional CT (3DCT). The predictive performance of these parameters was evaluated in terms of clinical outcomes and pathological invasiveness (positive lymphatic permeation, blood-vessel invasion, pleural invasion, and lymph-node metastasis).
We enrolled 170 patients with c-IA adenocarcinoma who underwent PET/CT, HRCT, and 3D reconstruction of lung structures using the Synapse Vincent system (Fujifilm Corporation, Tokyo, Japan) followed by complete resection. Maximum standardized uptake values (SUVmax) of F18-fluorodeoxyglucose and the size and volume of the solid part of the tumor were quantified and analyzed in relation to surgical outcomes.
Univariate analysis demonstrated that all the three parameters and whole-tumor volume were associated with unfavorable disease-free survival (DFS), while the volume of the solid part was the independent predictor on multivariate analysis (p 2.4 and solid-part volume > 779 mm3 versus those with SUVmax ≤ 2.4 or solid-part volume ≤779 mm3 were 81.2% versus 98.3% (p |
| doi_str_mv | 10.1016/j.lungcan.2018.05.001 |
| format | Article |
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The aim of this study was to conduct comparative analyses of the biological malignant potential of clinical stage IA adenocarcinoma using positron emission tomography/computed tomography (PET/CT), high-resolution CT (HRCT), and three-dimensional CT (3DCT). The predictive performance of these parameters was evaluated in terms of clinical outcomes and pathological invasiveness (positive lymphatic permeation, blood-vessel invasion, pleural invasion, and lymph-node metastasis).
We enrolled 170 patients with c-IA adenocarcinoma who underwent PET/CT, HRCT, and 3D reconstruction of lung structures using the Synapse Vincent system (Fujifilm Corporation, Tokyo, Japan) followed by complete resection. Maximum standardized uptake values (SUVmax) of F18-fluorodeoxyglucose and the size and volume of the solid part of the tumor were quantified and analyzed in relation to surgical outcomes.
Univariate analysis demonstrated that all the three parameters and whole-tumor volume were associated with unfavorable disease-free survival (DFS), while the volume of the solid part was the independent predictor on multivariate analysis (p < .001). The receiver operating characteristic curves for pathological invasiveness, determined using the variables dichotomized at each cut-off level (SUVmax 2.4; solid-part size 1.23 cm; solid-part volume 779 mm3), showed that all were significantly correlated with pathological invasiveness and prognosis, whereas the combination of SUVmax and the solid-part volume was the most powerful predictor of survival and pathological invasiveness compared to any other parameters: the 4-year DFS and proportion of pathological invasiveness in patients with SUVmax > 2.4 and solid-part volume > 779 mm3 versus those with SUVmax ≤ 2.4 or solid-part volume ≤779 mm3 were 81.2% versus 98.3% (p < .001) and 84.3% versus 15.1% (p < .001), respectively.
In c-IA adenocarcinoma, the volume of the solid part of the tumor was the independent predictor for unfavorable DFS, and the integration of the volume of the solid part and SUVmax was highly beneficial for the prediction of survival and pathological invasiveness.</description><identifier>ISSN: 0169-5002</identifier><identifier>EISSN: 1872-8332</identifier><identifier>DOI: 10.1016/j.lungcan.2018.05.001</identifier><identifier>PMID: 29858033</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Adenocarcinoma ; Adenocarcinoma - diagnosis ; Adenocarcinoma - mortality ; Adult ; Aged ; Aged, 80 and over ; Cone-Beam Computed Tomography - methods ; Female ; Fluorodeoxyglucose F18 ; Humans ; Lung - diagnostic imaging ; Lung - pathology ; Lung Neoplasms - diagnosis ; Lung Neoplasms - mortality ; Male ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; PET/CT ; Pneumonectomy ; Positron Emission Tomography Computed Tomography - methods ; Prognosis ; Stage IA ; Survival Analysis ; Three-dimensional CT ; Tumor Burden ; Tumor volume ; Young Adult</subject><ispartof>Lung cancer (Amsterdam, Netherlands), 2018-07, Vol.121, p.91-96</ispartof><rights>2018 Elsevier B.V.</rights><rights>Copyright © 2018 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-3e6c68f12f211cdfa7f86f8bca3210f00ac2f8d12490a662ba7a88a5ee9243933</citedby><cites>FETCH-LOGICAL-c431t-3e6c68f12f211cdfa7f86f8bca3210f00ac2f8d12490a662ba7a88a5ee9243933</cites><orcidid>0000-0003-3811-6159</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0169500218303660$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29858033$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Furumoto, Hideyuki</creatorcontrib><creatorcontrib>Shimada, Yoshihisa</creatorcontrib><creatorcontrib>Imai, Kentaro</creatorcontrib><creatorcontrib>Maehara, Sachio</creatorcontrib><creatorcontrib>Maeda, Junichi</creatorcontrib><creatorcontrib>Hagiwara, Masaru</creatorcontrib><creatorcontrib>Okano, Tetsuya</creatorcontrib><creatorcontrib>Masuno, Ryuhei</creatorcontrib><creatorcontrib>Kakihana, Masatoshi</creatorcontrib><creatorcontrib>Kajiwara, Naohiro</creatorcontrib><creatorcontrib>Ohira, Tatsuo</creatorcontrib><creatorcontrib>Ikeda, Norihiko</creatorcontrib><title>Prognostic impact of the integration of volumetric quantification of the solid part of the tumor on 3DCT and FDG-PET imaging in clinical stage IA adenocarcinoma of the lung</title><title>Lung cancer (Amsterdam, Netherlands)</title><addtitle>Lung Cancer</addtitle><description>•Solid-part volume of lung adenocarcinoma is a powerful predictor of prognosis.•The integration of solid-part volume and SUVmax of FDG is also highly useful.•Three-dimensional lung tumor analysis is beneficial for understanding lung cancer biology.
The aim of this study was to conduct comparative analyses of the biological malignant potential of clinical stage IA adenocarcinoma using positron emission tomography/computed tomography (PET/CT), high-resolution CT (HRCT), and three-dimensional CT (3DCT). The predictive performance of these parameters was evaluated in terms of clinical outcomes and pathological invasiveness (positive lymphatic permeation, blood-vessel invasion, pleural invasion, and lymph-node metastasis).
We enrolled 170 patients with c-IA adenocarcinoma who underwent PET/CT, HRCT, and 3D reconstruction of lung structures using the Synapse Vincent system (Fujifilm Corporation, Tokyo, Japan) followed by complete resection. Maximum standardized uptake values (SUVmax) of F18-fluorodeoxyglucose and the size and volume of the solid part of the tumor were quantified and analyzed in relation to surgical outcomes.
Univariate analysis demonstrated that all the three parameters and whole-tumor volume were associated with unfavorable disease-free survival (DFS), while the volume of the solid part was the independent predictor on multivariate analysis (p < .001). The receiver operating characteristic curves for pathological invasiveness, determined using the variables dichotomized at each cut-off level (SUVmax 2.4; solid-part size 1.23 cm; solid-part volume 779 mm3), showed that all were significantly correlated with pathological invasiveness and prognosis, whereas the combination of SUVmax and the solid-part volume was the most powerful predictor of survival and pathological invasiveness compared to any other parameters: the 4-year DFS and proportion of pathological invasiveness in patients with SUVmax > 2.4 and solid-part volume > 779 mm3 versus those with SUVmax ≤ 2.4 or solid-part volume ≤779 mm3 were 81.2% versus 98.3% (p < .001) and 84.3% versus 15.1% (p < .001), respectively.
In c-IA adenocarcinoma, the volume of the solid part of the tumor was the independent predictor for unfavorable DFS, and the integration of the volume of the solid part and SUVmax was highly beneficial for the prediction of survival and pathological invasiveness.</description><subject>Adenocarcinoma</subject><subject>Adenocarcinoma - diagnosis</subject><subject>Adenocarcinoma - mortality</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cone-Beam Computed Tomography - methods</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>Humans</subject><subject>Lung - diagnostic imaging</subject><subject>Lung - pathology</subject><subject>Lung Neoplasms - diagnosis</subject><subject>Lung Neoplasms - mortality</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>PET/CT</subject><subject>Pneumonectomy</subject><subject>Positron Emission Tomography Computed Tomography - methods</subject><subject>Prognosis</subject><subject>Stage IA</subject><subject>Survival Analysis</subject><subject>Three-dimensional CT</subject><subject>Tumor Burden</subject><subject>Tumor volume</subject><subject>Young Adult</subject><issn>0169-5002</issn><issn>1872-8332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u2zAQhImiReOmfYQWPPYilz-WTJ2KwPkFAjQH90ysqaVKQyIdkgrQd-pDloIdX3NaYPfbGQyGkK-cLTnjzY_9cph8b8AvBeNqyeolY_wdWXC1FpWSUrwni8K1Vc2YuCCfUtoXYM1Z-5FciFbVikm5IP-eYuh9SNkZ6sYDmEyDpfkPUucz9hGyC35evYRhGjHHwj1P4LOzzpyPM5_C4Dp6gHhWyNMYIi2EvN5sKfiO3l7fVU832-IEvfN98aBmcL4oDTRl6JE-XFHo0AcD0TgfRngVm9N-Jh8sDAm_nOYl-X17s93cV4-_7h42V4-VWUmeK4mNaZTlwgrOTWdhbVVj1c6AFJxZxsAIqzouVi2DphE7WINSUCO2YiVbKS_J96PuIYbnCVPWo0sGhwE8hilpwVZt3Qhez2h9RE0MKUW0-hBLuvhXc6bnovRen4rSc1Ga1br0UP6-nSym3Yjd-eu1mQL8PAJYgr44jDoZh95g5yKarLvg3rD4DxBgqPE</recordid><startdate>201807</startdate><enddate>201807</enddate><creator>Furumoto, Hideyuki</creator><creator>Shimada, Yoshihisa</creator><creator>Imai, Kentaro</creator><creator>Maehara, Sachio</creator><creator>Maeda, Junichi</creator><creator>Hagiwara, Masaru</creator><creator>Okano, Tetsuya</creator><creator>Masuno, Ryuhei</creator><creator>Kakihana, Masatoshi</creator><creator>Kajiwara, Naohiro</creator><creator>Ohira, Tatsuo</creator><creator>Ikeda, Norihiko</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3811-6159</orcidid></search><sort><creationdate>201807</creationdate><title>Prognostic impact of the integration of volumetric quantification of the solid part of the tumor on 3DCT and FDG-PET imaging in clinical stage IA adenocarcinoma of the lung</title><author>Furumoto, Hideyuki ; Shimada, Yoshihisa ; Imai, Kentaro ; Maehara, Sachio ; Maeda, Junichi ; Hagiwara, Masaru ; Okano, Tetsuya ; Masuno, Ryuhei ; Kakihana, Masatoshi ; Kajiwara, Naohiro ; Ohira, Tatsuo ; Ikeda, Norihiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-3e6c68f12f211cdfa7f86f8bca3210f00ac2f8d12490a662ba7a88a5ee9243933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adenocarcinoma</topic><topic>Adenocarcinoma - diagnosis</topic><topic>Adenocarcinoma - mortality</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cone-Beam Computed Tomography - methods</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18</topic><topic>Humans</topic><topic>Lung - diagnostic imaging</topic><topic>Lung - pathology</topic><topic>Lung Neoplasms - diagnosis</topic><topic>Lung Neoplasms - mortality</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>PET/CT</topic><topic>Pneumonectomy</topic><topic>Positron Emission Tomography Computed Tomography - methods</topic><topic>Prognosis</topic><topic>Stage IA</topic><topic>Survival Analysis</topic><topic>Three-dimensional CT</topic><topic>Tumor Burden</topic><topic>Tumor volume</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Furumoto, Hideyuki</creatorcontrib><creatorcontrib>Shimada, Yoshihisa</creatorcontrib><creatorcontrib>Imai, Kentaro</creatorcontrib><creatorcontrib>Maehara, Sachio</creatorcontrib><creatorcontrib>Maeda, Junichi</creatorcontrib><creatorcontrib>Hagiwara, Masaru</creatorcontrib><creatorcontrib>Okano, Tetsuya</creatorcontrib><creatorcontrib>Masuno, Ryuhei</creatorcontrib><creatorcontrib>Kakihana, Masatoshi</creatorcontrib><creatorcontrib>Kajiwara, Naohiro</creatorcontrib><creatorcontrib>Ohira, Tatsuo</creatorcontrib><creatorcontrib>Ikeda, Norihiko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Lung cancer (Amsterdam, Netherlands)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Furumoto, Hideyuki</au><au>Shimada, Yoshihisa</au><au>Imai, Kentaro</au><au>Maehara, Sachio</au><au>Maeda, Junichi</au><au>Hagiwara, Masaru</au><au>Okano, Tetsuya</au><au>Masuno, Ryuhei</au><au>Kakihana, Masatoshi</au><au>Kajiwara, Naohiro</au><au>Ohira, Tatsuo</au><au>Ikeda, Norihiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic impact of the integration of volumetric quantification of the solid part of the tumor on 3DCT and FDG-PET imaging in clinical stage IA adenocarcinoma of the lung</atitle><jtitle>Lung cancer (Amsterdam, Netherlands)</jtitle><addtitle>Lung Cancer</addtitle><date>2018-07</date><risdate>2018</risdate><volume>121</volume><spage>91</spage><epage>96</epage><pages>91-96</pages><issn>0169-5002</issn><eissn>1872-8332</eissn><abstract>•Solid-part volume of lung adenocarcinoma is a powerful predictor of prognosis.•The integration of solid-part volume and SUVmax of FDG is also highly useful.•Three-dimensional lung tumor analysis is beneficial for understanding lung cancer biology.
The aim of this study was to conduct comparative analyses of the biological malignant potential of clinical stage IA adenocarcinoma using positron emission tomography/computed tomography (PET/CT), high-resolution CT (HRCT), and three-dimensional CT (3DCT). The predictive performance of these parameters was evaluated in terms of clinical outcomes and pathological invasiveness (positive lymphatic permeation, blood-vessel invasion, pleural invasion, and lymph-node metastasis).
We enrolled 170 patients with c-IA adenocarcinoma who underwent PET/CT, HRCT, and 3D reconstruction of lung structures using the Synapse Vincent system (Fujifilm Corporation, Tokyo, Japan) followed by complete resection. Maximum standardized uptake values (SUVmax) of F18-fluorodeoxyglucose and the size and volume of the solid part of the tumor were quantified and analyzed in relation to surgical outcomes.
Univariate analysis demonstrated that all the three parameters and whole-tumor volume were associated with unfavorable disease-free survival (DFS), while the volume of the solid part was the independent predictor on multivariate analysis (p < .001). The receiver operating characteristic curves for pathological invasiveness, determined using the variables dichotomized at each cut-off level (SUVmax 2.4; solid-part size 1.23 cm; solid-part volume 779 mm3), showed that all were significantly correlated with pathological invasiveness and prognosis, whereas the combination of SUVmax and the solid-part volume was the most powerful predictor of survival and pathological invasiveness compared to any other parameters: the 4-year DFS and proportion of pathological invasiveness in patients with SUVmax > 2.4 and solid-part volume > 779 mm3 versus those with SUVmax ≤ 2.4 or solid-part volume ≤779 mm3 were 81.2% versus 98.3% (p < .001) and 84.3% versus 15.1% (p < .001), respectively.
In c-IA adenocarcinoma, the volume of the solid part of the tumor was the independent predictor for unfavorable DFS, and the integration of the volume of the solid part and SUVmax was highly beneficial for the prediction of survival and pathological invasiveness.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>29858033</pmid><doi>10.1016/j.lungcan.2018.05.001</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-3811-6159</orcidid></addata></record> |
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| subjects | Adenocarcinoma Adenocarcinoma - diagnosis Adenocarcinoma - mortality Adult Aged Aged, 80 and over Cone-Beam Computed Tomography - methods Female Fluorodeoxyglucose F18 Humans Lung - diagnostic imaging Lung - pathology Lung Neoplasms - diagnosis Lung Neoplasms - mortality Male Middle Aged Neoplasm Invasiveness Neoplasm Staging PET/CT Pneumonectomy Positron Emission Tomography Computed Tomography - methods Prognosis Stage IA Survival Analysis Three-dimensional CT Tumor Burden Tumor volume Young Adult |
| title | Prognostic impact of the integration of volumetric quantification of the solid part of the tumor on 3DCT and FDG-PET imaging in clinical stage IA adenocarcinoma of the lung |
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