Safety of dietary supplementation with arginine in adult humans
Previous studies with animals and humans have shown beneficial effects of dietary supplementation with l -arginine (Arg) on reducing white fat and improving health. At present, a long-term safe level of Arg administration to adult humans is unknown. The objective of this study was to conduct a rando...
Gespeichert in:
| Veröffentlicht in: | Amino acids 2018-09, Vol.50 (9), p.1215-1229 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1229 |
|---|---|
| container_issue | 9 |
| container_start_page | 1215 |
| container_title | Amino acids |
| container_volume | 50 |
| creator | McNeal, Catherine J. Meininger, Cynthia J. Wilborn, Colin D. Tekwe, Carmen D. Wu, Guoyao |
| description | Previous studies with animals and humans have shown beneficial effects of dietary supplementation with
l
-arginine (Arg) on reducing white fat and improving health. At present, a long-term safe level of Arg administration to adult humans is unknown. The objective of this study was to conduct a randomized, placebo-controlled, clinical trial to evaluate the safety and tolerability of oral Arg in overweight or obese but otherwise healthy adults with a body mass index of ≥ 25 kg/m
2
. A total of 142 subjects completed a 7-day wash-in period using a 12 g Arg/day dose. All the remaining eligible 101 subjects who tolerated the wash-in dose (45 men and 56 women) were assigned randomly to ingest 0, 15 or 30 g Arg (as pharmaceutical-grade Arg-HCl) per day for 90 days. Arg was taken daily in at least two divided doses by mixing with a flavored beverage. At Days 0 and 90, blood pressures of study subjects were recorded, their physical examinations were performed, and their blood and 24-h urine samples were obtained to measure: (1) serum concentrations of amino acids, glucose, fatty acids, and related metabolites; and (2) renal, hepatic, endocrine and metabolic parameters. Our results indicate that the serum concentration of Arg in men or women increased (
P
|
| doi_str_mv | 10.1007/s00726-018-2594-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2049560510</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2049560510</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-abb7f44f099017407eca7930085f4192eccd53026a99b0631509db56ce9442eb3</originalsourceid><addsrcrecordid>eNp1kM9LwzAUx4Mobk7_AC9S8OKl-pImTXISGf6CgQf1HNI23TLadDYpsv_ejE4FwUseIZ_3fXkfhM4xXGMAfuPjQfIUsEgJkzTlB2iKaRZvWMpDNAWZyZRShifoxPs1ACYC58doQqRgIhdiim5fdW3CNunqpLIm6H6b-GGzaUxrXNDBdi75tGGV6H5pnXUmsS7R1dCEZDW02vlTdFTrxpuzfZ2h94f7t_lTunh5fJ7fLdIy4ySkuih4TWkNUgLmFLgpNZcZgGA1xZKYsqxYBiTXUhaQZ5iBrAqWl0ZSSkyRzdDVmLvpu4_B-KBa60vTNNqZbvCKAJUsB4Yhopd_0HU39C7-bkeJGC5BRAqPVNl33vemVpvetnF_hUHt7KrRrop21c6u4rHnYp88FK2pfjq-dUaAjICPT25p-t_R_6d-ASCfg1E</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2048631908</pqid></control><display><type>article</type><title>Safety of dietary supplementation with arginine in adult humans</title><source>SpringerLink Journals - AutoHoldings</source><creator>McNeal, Catherine J. ; Meininger, Cynthia J. ; Wilborn, Colin D. ; Tekwe, Carmen D. ; Wu, Guoyao</creator><creatorcontrib>McNeal, Catherine J. ; Meininger, Cynthia J. ; Wilborn, Colin D. ; Tekwe, Carmen D. ; Wu, Guoyao</creatorcontrib><description>Previous studies with animals and humans have shown beneficial effects of dietary supplementation with
l
-arginine (Arg) on reducing white fat and improving health. At present, a long-term safe level of Arg administration to adult humans is unknown. The objective of this study was to conduct a randomized, placebo-controlled, clinical trial to evaluate the safety and tolerability of oral Arg in overweight or obese but otherwise healthy adults with a body mass index of ≥ 25 kg/m
2
. A total of 142 subjects completed a 7-day wash-in period using a 12 g Arg/day dose. All the remaining eligible 101 subjects who tolerated the wash-in dose (45 men and 56 women) were assigned randomly to ingest 0, 15 or 30 g Arg (as pharmaceutical-grade Arg-HCl) per day for 90 days. Arg was taken daily in at least two divided doses by mixing with a flavored beverage. At Days 0 and 90, blood pressures of study subjects were recorded, their physical examinations were performed, and their blood and 24-h urine samples were obtained to measure: (1) serum concentrations of amino acids, glucose, fatty acids, and related metabolites; and (2) renal, hepatic, endocrine and metabolic parameters. Our results indicate that the serum concentration of Arg in men or women increased (
P
< 0.05) progressively with increasing oral Arg doses from 0 to 30 g/day. Dietary supplementation with 30 g Arg/day reduced (
P
< 0.05) systolic blood pressure and serum glucose concentration in females, as well as serum concentrations of free fatty acids in both males and females. Based on physiological and biochemical variables, study subjects tolerated oral administration of 15 and 30 g Arg/day without adverse events. We conclude that a long-term safe level of dietary Arg supplementation is at least 30 g/day in adult humans.</description><identifier>ISSN: 0939-4451</identifier><identifier>EISSN: 1438-2199</identifier><identifier>DOI: 10.1007/s00726-018-2594-7</identifier><identifier>PMID: 29858688</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Adults ; Amino acids ; Analytical Chemistry ; Arginine ; Biochemical Engineering ; Biochemistry ; Biomedical and Life Sciences ; Blood pressure ; Body mass index ; Body size ; Body weight ; Clinical trials ; Dietary supplements ; Fatty acids ; Females ; Glucose ; Life Sciences ; Metabolites ; Neurobiology ; Oral administration ; Original Article ; Overweight ; Physical examinations ; Proteomics ; Safety ; Urine</subject><ispartof>Amino acids, 2018-09, Vol.50 (9), p.1215-1229</ispartof><rights>Springer-Verlag GmbH Austria, part of Springer Nature 2018</rights><rights>Amino Acids is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-abb7f44f099017407eca7930085f4192eccd53026a99b0631509db56ce9442eb3</citedby><cites>FETCH-LOGICAL-c372t-abb7f44f099017407eca7930085f4192eccd53026a99b0631509db56ce9442eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00726-018-2594-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00726-018-2594-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29858688$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McNeal, Catherine J.</creatorcontrib><creatorcontrib>Meininger, Cynthia J.</creatorcontrib><creatorcontrib>Wilborn, Colin D.</creatorcontrib><creatorcontrib>Tekwe, Carmen D.</creatorcontrib><creatorcontrib>Wu, Guoyao</creatorcontrib><title>Safety of dietary supplementation with arginine in adult humans</title><title>Amino acids</title><addtitle>Amino Acids</addtitle><addtitle>Amino Acids</addtitle><description>Previous studies with animals and humans have shown beneficial effects of dietary supplementation with
l
-arginine (Arg) on reducing white fat and improving health. At present, a long-term safe level of Arg administration to adult humans is unknown. The objective of this study was to conduct a randomized, placebo-controlled, clinical trial to evaluate the safety and tolerability of oral Arg in overweight or obese but otherwise healthy adults with a body mass index of ≥ 25 kg/m
2
. A total of 142 subjects completed a 7-day wash-in period using a 12 g Arg/day dose. All the remaining eligible 101 subjects who tolerated the wash-in dose (45 men and 56 women) were assigned randomly to ingest 0, 15 or 30 g Arg (as pharmaceutical-grade Arg-HCl) per day for 90 days. Arg was taken daily in at least two divided doses by mixing with a flavored beverage. At Days 0 and 90, blood pressures of study subjects were recorded, their physical examinations were performed, and their blood and 24-h urine samples were obtained to measure: (1) serum concentrations of amino acids, glucose, fatty acids, and related metabolites; and (2) renal, hepatic, endocrine and metabolic parameters. Our results indicate that the serum concentration of Arg in men or women increased (
P
< 0.05) progressively with increasing oral Arg doses from 0 to 30 g/day. Dietary supplementation with 30 g Arg/day reduced (
P
< 0.05) systolic blood pressure and serum glucose concentration in females, as well as serum concentrations of free fatty acids in both males and females. Based on physiological and biochemical variables, study subjects tolerated oral administration of 15 and 30 g Arg/day without adverse events. We conclude that a long-term safe level of dietary Arg supplementation is at least 30 g/day in adult humans.</description><subject>Adults</subject><subject>Amino acids</subject><subject>Analytical Chemistry</subject><subject>Arginine</subject><subject>Biochemical Engineering</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Blood pressure</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Body weight</subject><subject>Clinical trials</subject><subject>Dietary supplements</subject><subject>Fatty acids</subject><subject>Females</subject><subject>Glucose</subject><subject>Life Sciences</subject><subject>Metabolites</subject><subject>Neurobiology</subject><subject>Oral administration</subject><subject>Original Article</subject><subject>Overweight</subject><subject>Physical examinations</subject><subject>Proteomics</subject><subject>Safety</subject><subject>Urine</subject><issn>0939-4451</issn><issn>1438-2199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kM9LwzAUx4Mobk7_AC9S8OKl-pImTXISGf6CgQf1HNI23TLadDYpsv_ejE4FwUseIZ_3fXkfhM4xXGMAfuPjQfIUsEgJkzTlB2iKaRZvWMpDNAWZyZRShifoxPs1ACYC58doQqRgIhdiim5fdW3CNunqpLIm6H6b-GGzaUxrXNDBdi75tGGV6H5pnXUmsS7R1dCEZDW02vlTdFTrxpuzfZ2h94f7t_lTunh5fJ7fLdIy4ySkuih4TWkNUgLmFLgpNZcZgGA1xZKYsqxYBiTXUhaQZ5iBrAqWl0ZSSkyRzdDVmLvpu4_B-KBa60vTNNqZbvCKAJUsB4Yhopd_0HU39C7-bkeJGC5BRAqPVNl33vemVpvetnF_hUHt7KrRrop21c6u4rHnYp88FK2pfjq-dUaAjICPT25p-t_R_6d-ASCfg1E</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>McNeal, Catherine J.</creator><creator>Meininger, Cynthia J.</creator><creator>Wilborn, Colin D.</creator><creator>Tekwe, Carmen D.</creator><creator>Wu, Guoyao</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20180901</creationdate><title>Safety of dietary supplementation with arginine in adult humans</title><author>McNeal, Catherine J. ; Meininger, Cynthia J. ; Wilborn, Colin D. ; Tekwe, Carmen D. ; Wu, Guoyao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-abb7f44f099017407eca7930085f4192eccd53026a99b0631509db56ce9442eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adults</topic><topic>Amino acids</topic><topic>Analytical Chemistry</topic><topic>Arginine</topic><topic>Biochemical Engineering</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Blood pressure</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Body weight</topic><topic>Clinical trials</topic><topic>Dietary supplements</topic><topic>Fatty acids</topic><topic>Females</topic><topic>Glucose</topic><topic>Life Sciences</topic><topic>Metabolites</topic><topic>Neurobiology</topic><topic>Oral administration</topic><topic>Original Article</topic><topic>Overweight</topic><topic>Physical examinations</topic><topic>Proteomics</topic><topic>Safety</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McNeal, Catherine J.</creatorcontrib><creatorcontrib>Meininger, Cynthia J.</creatorcontrib><creatorcontrib>Wilborn, Colin D.</creatorcontrib><creatorcontrib>Tekwe, Carmen D.</creatorcontrib><creatorcontrib>Wu, Guoyao</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Amino acids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McNeal, Catherine J.</au><au>Meininger, Cynthia J.</au><au>Wilborn, Colin D.</au><au>Tekwe, Carmen D.</au><au>Wu, Guoyao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Safety of dietary supplementation with arginine in adult humans</atitle><jtitle>Amino acids</jtitle><stitle>Amino Acids</stitle><addtitle>Amino Acids</addtitle><date>2018-09-01</date><risdate>2018</risdate><volume>50</volume><issue>9</issue><spage>1215</spage><epage>1229</epage><pages>1215-1229</pages><issn>0939-4451</issn><eissn>1438-2199</eissn><abstract>Previous studies with animals and humans have shown beneficial effects of dietary supplementation with
l
-arginine (Arg) on reducing white fat and improving health. At present, a long-term safe level of Arg administration to adult humans is unknown. The objective of this study was to conduct a randomized, placebo-controlled, clinical trial to evaluate the safety and tolerability of oral Arg in overweight or obese but otherwise healthy adults with a body mass index of ≥ 25 kg/m
2
. A total of 142 subjects completed a 7-day wash-in period using a 12 g Arg/day dose. All the remaining eligible 101 subjects who tolerated the wash-in dose (45 men and 56 women) were assigned randomly to ingest 0, 15 or 30 g Arg (as pharmaceutical-grade Arg-HCl) per day for 90 days. Arg was taken daily in at least two divided doses by mixing with a flavored beverage. At Days 0 and 90, blood pressures of study subjects were recorded, their physical examinations were performed, and their blood and 24-h urine samples were obtained to measure: (1) serum concentrations of amino acids, glucose, fatty acids, and related metabolites; and (2) renal, hepatic, endocrine and metabolic parameters. Our results indicate that the serum concentration of Arg in men or women increased (
P
< 0.05) progressively with increasing oral Arg doses from 0 to 30 g/day. Dietary supplementation with 30 g Arg/day reduced (
P
< 0.05) systolic blood pressure and serum glucose concentration in females, as well as serum concentrations of free fatty acids in both males and females. Based on physiological and biochemical variables, study subjects tolerated oral administration of 15 and 30 g Arg/day without adverse events. We conclude that a long-term safe level of dietary Arg supplementation is at least 30 g/day in adult humans.</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>29858688</pmid><doi>10.1007/s00726-018-2594-7</doi><tpages>15</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0939-4451 |
| ispartof | Amino acids, 2018-09, Vol.50 (9), p.1215-1229 |
| issn | 0939-4451 1438-2199 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2049560510 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Adults Amino acids Analytical Chemistry Arginine Biochemical Engineering Biochemistry Biomedical and Life Sciences Blood pressure Body mass index Body size Body weight Clinical trials Dietary supplements Fatty acids Females Glucose Life Sciences Metabolites Neurobiology Oral administration Original Article Overweight Physical examinations Proteomics Safety Urine |
| title | Safety of dietary supplementation with arginine in adult humans |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T18%3A40%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Safety%20of%20dietary%20supplementation%20with%20arginine%20in%20adult%20humans&rft.jtitle=Amino%20acids&rft.au=McNeal,%20Catherine%20J.&rft.date=2018-09-01&rft.volume=50&rft.issue=9&rft.spage=1215&rft.epage=1229&rft.pages=1215-1229&rft.issn=0939-4451&rft.eissn=1438-2199&rft_id=info:doi/10.1007/s00726-018-2594-7&rft_dat=%3Cproquest_cross%3E2049560510%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2048631908&rft_id=info:pmid/29858688&rfr_iscdi=true |