Characterization of group B Streptococcus isolated from sterile and non-sterile specimens in China
Group B streptococcus (GBS) is a leading cause of invasive neonatal infections and has increasingly been associated with invasive diseases in non-pregnant adults. We collected 113 GBS isolates recovered from sterile and non-sterile specimens from seven tertiary hospitals in China between October 201...
Gespeichert in:
| Veröffentlicht in: | Diagnostic microbiology and infectious disease 2018-09, Vol.92 (1), p.56-61 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 61 |
|---|---|
| container_issue | 1 |
| container_start_page | 56 |
| container_title | Diagnostic microbiology and infectious disease |
| container_volume | 92 |
| creator | Nie, Shuping Lu, Xuedong Jin, Zhengjiang Gao, Juyi Ma, Dongli Deng, Jikui Wu, Xianglin Hu, Yan-Wei Zheng, Lei Wang, Qian |
| description | Group B streptococcus (GBS) is a leading cause of invasive neonatal infections and has increasingly been associated with invasive diseases in non-pregnant adults. We collected 113 GBS isolates recovered from sterile and non-sterile specimens from seven tertiary hospitals in China between October 2014 and September 2016. Medical records were retrospectively reviewed and the sequence types, serotypes, virulence, and antimicrobial resistance profiles of the isolates were characterized and correlated. Significantly higher C-reactive protein and procalcitonin levels and absolute neutrophil counts were observed in patients with invasive infections than in those with non-invasive infections (P |
| doi_str_mv | 10.1016/j.diagmicrobio.2018.04.014 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2049559456</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S073288931830141X</els_id><sourcerecordid>2049559456</sourcerecordid><originalsourceid>FETCH-LOGICAL-c380t-513914df54d60a6d7889573dd2de400b304c758d2fc30766ba4c2935c7270df93</originalsourceid><addsrcrecordid>eNqNkE1v1DAQhi0EokvhLyCLE5eE8VeccINtaZEqcSicLceetF4ldrATJPj1zWpbxJHTaKTnnY-HkHcMagas-XCofbB3U3A59SHVHFhbg6yByWdkx1rdVQAanpMdaMGrtu3EGXlVygGA8U7CS3LGu1a1jPEd6ff3Nlu3YA5_7BJSpGmgdzmtM_1Mb5eM85Jccm4tNJQ02gU9HXKaaDlGRqQ2ehpTrJ76MqMLE8aNj3R_H6J9TV4Mdiz45rGekx9fLr_vr6ubb1df959uKidaWCrFRMekH5T0DdjG6-1wpYX33KME6AVIp1Xr-eAE6KbprXS8E8pprsEPnTgn709z55x-rlgWM4XicBxtxLQWw0F2SnVSNRv68YRuCkvJOJg5h8nm34aBOTo2B_OvY3N0bECazfEWfvu4Z-0n9H-jT1I34OIE4Pbtr4DZFBcwOvQho1uMT-F_9jwAHh6U2Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2049559456</pqid></control><display><type>article</type><title>Characterization of group B Streptococcus isolated from sterile and non-sterile specimens in China</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Nie, Shuping ; Lu, Xuedong ; Jin, Zhengjiang ; Gao, Juyi ; Ma, Dongli ; Deng, Jikui ; Wu, Xianglin ; Hu, Yan-Wei ; Zheng, Lei ; Wang, Qian</creator><creatorcontrib>Nie, Shuping ; Lu, Xuedong ; Jin, Zhengjiang ; Gao, Juyi ; Ma, Dongli ; Deng, Jikui ; Wu, Xianglin ; Hu, Yan-Wei ; Zheng, Lei ; Wang, Qian</creatorcontrib><description>Group B streptococcus (GBS) is a leading cause of invasive neonatal infections and has increasingly been associated with invasive diseases in non-pregnant adults. We collected 113 GBS isolates recovered from sterile and non-sterile specimens from seven tertiary hospitals in China between October 2014 and September 2016. Medical records were retrospectively reviewed and the sequence types, serotypes, virulence, and antimicrobial resistance profiles of the isolates were characterized and correlated. Significantly higher C-reactive protein and procalcitonin levels and absolute neutrophil counts were observed in patients with invasive infections than in those with non-invasive infections (P < 0.05). The 113 isolates were grouped into 24 sequence types, 5 clonal complexes, and 6 serotypes. multivariate analysis revealed that clonal complex 17 isolates characterized by serotype iii, the surface protein gene rib, and the pilus island pi-2b were independently correlated with invasive infection (or: 6.79; 95% ci: 2.31–19.94, P < 0.001). These results suggest alternative molecular biomarkers for diagnosis and prognosis of GBS infections.
•Fifty-one GBS isolates recovered from sterile sites and 62 isolates from non-sterile sites were characterized.•GBS isolates recovered from sterile sites were more common in newborns aged 7–89 days.•The inflammatory markers CRP, PCT, and ANC may play roles in the diagnosis of invasive GBS infections.•Clonal complex 17 isolates were independently correlated with invasive infections in China.</description><identifier>ISSN: 0732-8893</identifier><identifier>EISSN: 1879-0070</identifier><identifier>DOI: 10.1016/j.diagmicrobio.2018.04.014</identifier><identifier>PMID: 29858112</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents - therapeutic use ; Child ; Child, Preschool ; China ; Clonal complex ; Drug Resistance, Bacterial - drug effects ; Drug Resistance, Bacterial - genetics ; Female ; Genotype ; Group B Streptococcus ; Humans ; Infant ; Infant, Newborn ; Male ; Microbial Sensitivity Tests - methods ; Middle Aged ; Multilocus sequence typing ; Multilocus Sequence Typing - methods ; Retrospective Studies ; Serogroup ; Serotyping ; Serotyping - methods ; Streptococcal Infections - drug therapy ; Streptococcal Infections - microbiology ; Streptococcus - drug effects ; Streptococcus - genetics ; Streptococcus - isolation & purification ; Virulence factor ; Young Adult</subject><ispartof>Diagnostic microbiology and infectious disease, 2018-09, Vol.92 (1), p.56-61</ispartof><rights>2018 Elsevier Inc.</rights><rights>Copyright © 2018 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c380t-513914df54d60a6d7889573dd2de400b304c758d2fc30766ba4c2935c7270df93</citedby><cites>FETCH-LOGICAL-c380t-513914df54d60a6d7889573dd2de400b304c758d2fc30766ba4c2935c7270df93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.diagmicrobio.2018.04.014$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29858112$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nie, Shuping</creatorcontrib><creatorcontrib>Lu, Xuedong</creatorcontrib><creatorcontrib>Jin, Zhengjiang</creatorcontrib><creatorcontrib>Gao, Juyi</creatorcontrib><creatorcontrib>Ma, Dongli</creatorcontrib><creatorcontrib>Deng, Jikui</creatorcontrib><creatorcontrib>Wu, Xianglin</creatorcontrib><creatorcontrib>Hu, Yan-Wei</creatorcontrib><creatorcontrib>Zheng, Lei</creatorcontrib><creatorcontrib>Wang, Qian</creatorcontrib><title>Characterization of group B Streptococcus isolated from sterile and non-sterile specimens in China</title><title>Diagnostic microbiology and infectious disease</title><addtitle>Diagn Microbiol Infect Dis</addtitle><description>Group B streptococcus (GBS) is a leading cause of invasive neonatal infections and has increasingly been associated with invasive diseases in non-pregnant adults. We collected 113 GBS isolates recovered from sterile and non-sterile specimens from seven tertiary hospitals in China between October 2014 and September 2016. Medical records were retrospectively reviewed and the sequence types, serotypes, virulence, and antimicrobial resistance profiles of the isolates were characterized and correlated. Significantly higher C-reactive protein and procalcitonin levels and absolute neutrophil counts were observed in patients with invasive infections than in those with non-invasive infections (P < 0.05). The 113 isolates were grouped into 24 sequence types, 5 clonal complexes, and 6 serotypes. multivariate analysis revealed that clonal complex 17 isolates characterized by serotype iii, the surface protein gene rib, and the pilus island pi-2b were independently correlated with invasive infection (or: 6.79; 95% ci: 2.31–19.94, P < 0.001). These results suggest alternative molecular biomarkers for diagnosis and prognosis of GBS infections.
•Fifty-one GBS isolates recovered from sterile sites and 62 isolates from non-sterile sites were characterized.•GBS isolates recovered from sterile sites were more common in newborns aged 7–89 days.•The inflammatory markers CRP, PCT, and ANC may play roles in the diagnosis of invasive GBS infections.•Clonal complex 17 isolates were independently correlated with invasive infections in China.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>China</subject><subject>Clonal complex</subject><subject>Drug Resistance, Bacterial - drug effects</subject><subject>Drug Resistance, Bacterial - genetics</subject><subject>Female</subject><subject>Genotype</subject><subject>Group B Streptococcus</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Microbial Sensitivity Tests - methods</subject><subject>Middle Aged</subject><subject>Multilocus sequence typing</subject><subject>Multilocus Sequence Typing - methods</subject><subject>Retrospective Studies</subject><subject>Serogroup</subject><subject>Serotyping</subject><subject>Serotyping - methods</subject><subject>Streptococcal Infections - drug therapy</subject><subject>Streptococcal Infections - microbiology</subject><subject>Streptococcus - drug effects</subject><subject>Streptococcus - genetics</subject><subject>Streptococcus - isolation & purification</subject><subject>Virulence factor</subject><subject>Young Adult</subject><issn>0732-8893</issn><issn>1879-0070</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1v1DAQhi0EokvhLyCLE5eE8VeccINtaZEqcSicLceetF4ldrATJPj1zWpbxJHTaKTnnY-HkHcMagas-XCofbB3U3A59SHVHFhbg6yByWdkx1rdVQAanpMdaMGrtu3EGXlVygGA8U7CS3LGu1a1jPEd6ff3Nlu3YA5_7BJSpGmgdzmtM_1Mb5eM85Jccm4tNJQ02gU9HXKaaDlGRqQ2ehpTrJ76MqMLE8aNj3R_H6J9TV4Mdiz45rGekx9fLr_vr6ubb1df959uKidaWCrFRMekH5T0DdjG6-1wpYX33KME6AVIp1Xr-eAE6KbprXS8E8pprsEPnTgn709z55x-rlgWM4XicBxtxLQWw0F2SnVSNRv68YRuCkvJOJg5h8nm34aBOTo2B_OvY3N0bECazfEWfvu4Z-0n9H-jT1I34OIE4Pbtr4DZFBcwOvQho1uMT-F_9jwAHh6U2Q</recordid><startdate>201809</startdate><enddate>201809</enddate><creator>Nie, Shuping</creator><creator>Lu, Xuedong</creator><creator>Jin, Zhengjiang</creator><creator>Gao, Juyi</creator><creator>Ma, Dongli</creator><creator>Deng, Jikui</creator><creator>Wu, Xianglin</creator><creator>Hu, Yan-Wei</creator><creator>Zheng, Lei</creator><creator>Wang, Qian</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201809</creationdate><title>Characterization of group B Streptococcus isolated from sterile and non-sterile specimens in China</title><author>Nie, Shuping ; Lu, Xuedong ; Jin, Zhengjiang ; Gao, Juyi ; Ma, Dongli ; Deng, Jikui ; Wu, Xianglin ; Hu, Yan-Wei ; Zheng, Lei ; Wang, Qian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-513914df54d60a6d7889573dd2de400b304c758d2fc30766ba4c2935c7270df93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>China</topic><topic>Clonal complex</topic><topic>Drug Resistance, Bacterial - drug effects</topic><topic>Drug Resistance, Bacterial - genetics</topic><topic>Female</topic><topic>Genotype</topic><topic>Group B Streptococcus</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Microbial Sensitivity Tests - methods</topic><topic>Middle Aged</topic><topic>Multilocus sequence typing</topic><topic>Multilocus Sequence Typing - methods</topic><topic>Retrospective Studies</topic><topic>Serogroup</topic><topic>Serotyping</topic><topic>Serotyping - methods</topic><topic>Streptococcal Infections - drug therapy</topic><topic>Streptococcal Infections - microbiology</topic><topic>Streptococcus - drug effects</topic><topic>Streptococcus - genetics</topic><topic>Streptococcus - isolation & purification</topic><topic>Virulence factor</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nie, Shuping</creatorcontrib><creatorcontrib>Lu, Xuedong</creatorcontrib><creatorcontrib>Jin, Zhengjiang</creatorcontrib><creatorcontrib>Gao, Juyi</creatorcontrib><creatorcontrib>Ma, Dongli</creatorcontrib><creatorcontrib>Deng, Jikui</creatorcontrib><creatorcontrib>Wu, Xianglin</creatorcontrib><creatorcontrib>Hu, Yan-Wei</creatorcontrib><creatorcontrib>Zheng, Lei</creatorcontrib><creatorcontrib>Wang, Qian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diagnostic microbiology and infectious disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nie, Shuping</au><au>Lu, Xuedong</au><au>Jin, Zhengjiang</au><au>Gao, Juyi</au><au>Ma, Dongli</au><au>Deng, Jikui</au><au>Wu, Xianglin</au><au>Hu, Yan-Wei</au><au>Zheng, Lei</au><au>Wang, Qian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of group B Streptococcus isolated from sterile and non-sterile specimens in China</atitle><jtitle>Diagnostic microbiology and infectious disease</jtitle><addtitle>Diagn Microbiol Infect Dis</addtitle><date>2018-09</date><risdate>2018</risdate><volume>92</volume><issue>1</issue><spage>56</spage><epage>61</epage><pages>56-61</pages><issn>0732-8893</issn><eissn>1879-0070</eissn><abstract>Group B streptococcus (GBS) is a leading cause of invasive neonatal infections and has increasingly been associated with invasive diseases in non-pregnant adults. We collected 113 GBS isolates recovered from sterile and non-sterile specimens from seven tertiary hospitals in China between October 2014 and September 2016. Medical records were retrospectively reviewed and the sequence types, serotypes, virulence, and antimicrobial resistance profiles of the isolates were characterized and correlated. Significantly higher C-reactive protein and procalcitonin levels and absolute neutrophil counts were observed in patients with invasive infections than in those with non-invasive infections (P < 0.05). The 113 isolates were grouped into 24 sequence types, 5 clonal complexes, and 6 serotypes. multivariate analysis revealed that clonal complex 17 isolates characterized by serotype iii, the surface protein gene rib, and the pilus island pi-2b were independently correlated with invasive infection (or: 6.79; 95% ci: 2.31–19.94, P < 0.001). These results suggest alternative molecular biomarkers for diagnosis and prognosis of GBS infections.
•Fifty-one GBS isolates recovered from sterile sites and 62 isolates from non-sterile sites were characterized.•GBS isolates recovered from sterile sites were more common in newborns aged 7–89 days.•The inflammatory markers CRP, PCT, and ANC may play roles in the diagnosis of invasive GBS infections.•Clonal complex 17 isolates were independently correlated with invasive infections in China.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>29858112</pmid><doi>10.1016/j.diagmicrobio.2018.04.014</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0732-8893 |
| ispartof | Diagnostic microbiology and infectious disease, 2018-09, Vol.92 (1), p.56-61 |
| issn | 0732-8893 1879-0070 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2049559456 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adolescent Adult Aged Aged, 80 and over Anti-Bacterial Agents - therapeutic use Child Child, Preschool China Clonal complex Drug Resistance, Bacterial - drug effects Drug Resistance, Bacterial - genetics Female Genotype Group B Streptococcus Humans Infant Infant, Newborn Male Microbial Sensitivity Tests - methods Middle Aged Multilocus sequence typing Multilocus Sequence Typing - methods Retrospective Studies Serogroup Serotyping Serotyping - methods Streptococcal Infections - drug therapy Streptococcal Infections - microbiology Streptococcus - drug effects Streptococcus - genetics Streptococcus - isolation & purification Virulence factor Young Adult |
| title | Characterization of group B Streptococcus isolated from sterile and non-sterile specimens in China |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-13T13%3A16%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Characterization%20of%20group%20B%20Streptococcus%20isolated%20from%20sterile%20and%20non-sterile%20specimens%20in%20China&rft.jtitle=Diagnostic%20microbiology%20and%20infectious%20disease&rft.au=Nie,%20Shuping&rft.date=2018-09&rft.volume=92&rft.issue=1&rft.spage=56&rft.epage=61&rft.pages=56-61&rft.issn=0732-8893&rft.eissn=1879-0070&rft_id=info:doi/10.1016/j.diagmicrobio.2018.04.014&rft_dat=%3Cproquest_cross%3E2049559456%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2049559456&rft_id=info:pmid/29858112&rft_els_id=S073288931830141X&rfr_iscdi=true |