Honokiol Exerts Antidepressant Effects in Rats Exposed to Chronic Unpredictable Mild Stress by Regulating Brain Derived Neurotrophic Factor Level and Hypothalamus–Pituitary–Adrenal Axis Activity
Honokiol (HNK), the main active component of Magnolia officinalis , has shown a variety of pharmacological activities. In the present study, we measured the antidepressant-like effects of HNK in a rat model of chronic unpredictable mild stress (CUMS) and explored its possible mechanisms. The antidep...
Gespeichert in:
| Veröffentlicht in: | Neurochemical research 2018-08, Vol.43 (8), p.1519-1528 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1528 |
|---|---|
| container_issue | 8 |
| container_start_page | 1519 |
| container_title | Neurochemical research |
| container_volume | 43 |
| creator | Wang, Canmao Gan, Danna Wu, Jingang Liao, Minhui Liao, Xinghuan Ai, Weipeng |
| description | Honokiol (HNK), the main active component of
Magnolia officinalis
, has shown a variety of pharmacological activities. In the present study, we measured the antidepressant-like effects of HNK in a rat model of chronic unpredictable mild stress (CUMS) and explored its possible mechanisms. The antidepressant-like effects of HNK were assessed in rats by an open field test (OFT), sucrose preference test (SPT) and forced swimming test (FST). Then, serum levels of corticotrophin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH) and corticosterone (CORT) and hippocampal brain-derived neurotrophic factor (BDNF) and glucocorticoid receptor α (GRα) levels were assessed to explore the possible mechanisms. We identified that HNK treatment (2, 4, and 8 mg/kg) alleviated the CUMS-induced behavioural deficits. Treatment with HNK also normalized the CUMS-induced hyperactivity of the limbic hypothalamic–pituitary–adrenal (HPA) axis, as indicated by reduced CRH, ACTH and CORT serum levels. In addition, HNK increased the expression of GRα (mRNA and protein) and BDNF (mRNA and protein) in the hippocampus. These data confirmed the antidepressant-like effects of HNK, which may be related to its normalizing the function of the HPA axis and increasing the BDNF level in the hippocampus. |
| doi_str_mv | 10.1007/s11064-018-2566-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2049557338</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2049557338</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-2b8321efce2dfc2380aafa07fedf298c4ee1d5d1a63931f5277dcb338ee635e3</originalsourceid><addsrcrecordid>eNp1kctuEzEUhkcIREPhAdggS2zYDPgy12UIKUEKF5WyHnns48TFsae2J0q66jv0nXgQngSnKSAhsTqWz_f_59h_lj0n-DXBuH4TCMFVkWPS5LSsqvz6QTYhZc3yqsXsYTbBLHUZafFJ9iSES4yTipLH2Qltm7JsimqS_Vg4675rZ9B8Bz4GNLVRSxg8hMBtRHOlQKRrbdE5T3W-G1wAiaJDs7V3Vgv0zSZaahF5bwB91Eair_GgR_0encNqNDxqu0JvPU8u78DrbTL4BKN30bthnSzOuIjOoyVswSBuJVrsBxfX3PDNGH7e3H7RcdSR-306T6UHyw2a7nTaVkS91XH_NHukuAnw7L6eZhdn84vZIl9-fv9hNl3momBNzGnfMEpACaBSCcoazLniuFYgVfoTUQAQWUrCK9Yyokpa11L0jDUAFSuBnWavjraDd1cjhNhtdBBgDLfgxtBRXLRlCoA1CX35D3rpRp8Wv6PqtqTkjiJHSngXggfVDV5v0kM7grtDxt0x4y5l3B0y7q6T5sW989hvQP5R_A41AfQIhNSyK_B_R__f9RejmLle</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2047952138</pqid></control><display><type>article</type><title>Honokiol Exerts Antidepressant Effects in Rats Exposed to Chronic Unpredictable Mild Stress by Regulating Brain Derived Neurotrophic Factor Level and Hypothalamus–Pituitary–Adrenal Axis Activity</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Wang, Canmao ; Gan, Danna ; Wu, Jingang ; Liao, Minhui ; Liao, Xinghuan ; Ai, Weipeng</creator><creatorcontrib>Wang, Canmao ; Gan, Danna ; Wu, Jingang ; Liao, Minhui ; Liao, Xinghuan ; Ai, Weipeng</creatorcontrib><description>Honokiol (HNK), the main active component of
Magnolia officinalis
, has shown a variety of pharmacological activities. In the present study, we measured the antidepressant-like effects of HNK in a rat model of chronic unpredictable mild stress (CUMS) and explored its possible mechanisms. The antidepressant-like effects of HNK were assessed in rats by an open field test (OFT), sucrose preference test (SPT) and forced swimming test (FST). Then, serum levels of corticotrophin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH) and corticosterone (CORT) and hippocampal brain-derived neurotrophic factor (BDNF) and glucocorticoid receptor α (GRα) levels were assessed to explore the possible mechanisms. We identified that HNK treatment (2, 4, and 8 mg/kg) alleviated the CUMS-induced behavioural deficits. Treatment with HNK also normalized the CUMS-induced hyperactivity of the limbic hypothalamic–pituitary–adrenal (HPA) axis, as indicated by reduced CRH, ACTH and CORT serum levels. In addition, HNK increased the expression of GRα (mRNA and protein) and BDNF (mRNA and protein) in the hippocampus. These data confirmed the antidepressant-like effects of HNK, which may be related to its normalizing the function of the HPA axis and increasing the BDNF level in the hippocampus.</description><identifier>ISSN: 0364-3190</identifier><identifier>EISSN: 1573-6903</identifier><identifier>DOI: 10.1007/s11064-018-2566-z</identifier><identifier>PMID: 29855846</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adrenocorticotropic hormone ; Animals ; Antidepressants ; Antidepressive Agents - therapeutic use ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Biphenyl Compounds - pharmacology ; Biphenyl Compounds - therapeutic use ; Brain ; Brain-derived neurotrophic factor ; Brain-Derived Neurotrophic Factor - metabolism ; Cell Biology ; Chronic Disease ; Corticosterone ; Corticotropin-releasing hormone ; Dose-Response Relationship, Drug ; Field tests ; Gene expression ; Glucocorticoids ; Hippocampus ; Hippocampus - drug effects ; Hippocampus - metabolism ; Hyperactivity ; Hypothalamic-pituitary-adrenal axis ; Hypothalamo-Hypophyseal System - drug effects ; Hypothalamo-Hypophyseal System - metabolism ; Hypothalamus ; Lignans - pharmacology ; Lignans - therapeutic use ; Male ; mRNA ; Neurochemistry ; Neurology ; Neurosciences ; Normalizing ; Open-field behavior ; Original Paper ; Pharmacology ; Pituitary ; Pituitary-Adrenal System - drug effects ; Pituitary-Adrenal System - metabolism ; Proteins ; Rats ; Rats, Wistar ; Rodents ; Serum levels ; Stress, Psychological - drug therapy ; Stress, Psychological - metabolism ; Stress, Psychological - psychology ; Sucrose ; Sugar ; Swimming ; Treatment Outcome</subject><ispartof>Neurochemical research, 2018-08, Vol.43 (8), p.1519-1528</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>Neurochemical Research is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-2b8321efce2dfc2380aafa07fedf298c4ee1d5d1a63931f5277dcb338ee635e3</citedby><cites>FETCH-LOGICAL-c438t-2b8321efce2dfc2380aafa07fedf298c4ee1d5d1a63931f5277dcb338ee635e3</cites><orcidid>0000-0002-0057-9775</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11064-018-2566-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11064-018-2566-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27925,27926,41489,42558,51320</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29855846$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Canmao</creatorcontrib><creatorcontrib>Gan, Danna</creatorcontrib><creatorcontrib>Wu, Jingang</creatorcontrib><creatorcontrib>Liao, Minhui</creatorcontrib><creatorcontrib>Liao, Xinghuan</creatorcontrib><creatorcontrib>Ai, Weipeng</creatorcontrib><title>Honokiol Exerts Antidepressant Effects in Rats Exposed to Chronic Unpredictable Mild Stress by Regulating Brain Derived Neurotrophic Factor Level and Hypothalamus–Pituitary–Adrenal Axis Activity</title><title>Neurochemical research</title><addtitle>Neurochem Res</addtitle><addtitle>Neurochem Res</addtitle><description>Honokiol (HNK), the main active component of
Magnolia officinalis
, has shown a variety of pharmacological activities. In the present study, we measured the antidepressant-like effects of HNK in a rat model of chronic unpredictable mild stress (CUMS) and explored its possible mechanisms. The antidepressant-like effects of HNK were assessed in rats by an open field test (OFT), sucrose preference test (SPT) and forced swimming test (FST). Then, serum levels of corticotrophin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH) and corticosterone (CORT) and hippocampal brain-derived neurotrophic factor (BDNF) and glucocorticoid receptor α (GRα) levels were assessed to explore the possible mechanisms. We identified that HNK treatment (2, 4, and 8 mg/kg) alleviated the CUMS-induced behavioural deficits. Treatment with HNK also normalized the CUMS-induced hyperactivity of the limbic hypothalamic–pituitary–adrenal (HPA) axis, as indicated by reduced CRH, ACTH and CORT serum levels. In addition, HNK increased the expression of GRα (mRNA and protein) and BDNF (mRNA and protein) in the hippocampus. These data confirmed the antidepressant-like effects of HNK, which may be related to its normalizing the function of the HPA axis and increasing the BDNF level in the hippocampus.</description><subject>Adrenocorticotropic hormone</subject><subject>Animals</subject><subject>Antidepressants</subject><subject>Antidepressive Agents - therapeutic use</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Biphenyl Compounds - pharmacology</subject><subject>Biphenyl Compounds - therapeutic use</subject><subject>Brain</subject><subject>Brain-derived neurotrophic factor</subject><subject>Brain-Derived Neurotrophic Factor - metabolism</subject><subject>Cell Biology</subject><subject>Chronic Disease</subject><subject>Corticosterone</subject><subject>Corticotropin-releasing hormone</subject><subject>Dose-Response Relationship, Drug</subject><subject>Field tests</subject><subject>Gene expression</subject><subject>Glucocorticoids</subject><subject>Hippocampus</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>Hyperactivity</subject><subject>Hypothalamic-pituitary-adrenal axis</subject><subject>Hypothalamo-Hypophyseal System - drug effects</subject><subject>Hypothalamo-Hypophyseal System - metabolism</subject><subject>Hypothalamus</subject><subject>Lignans - pharmacology</subject><subject>Lignans - therapeutic use</subject><subject>Male</subject><subject>mRNA</subject><subject>Neurochemistry</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Normalizing</subject><subject>Open-field behavior</subject><subject>Original Paper</subject><subject>Pharmacology</subject><subject>Pituitary</subject><subject>Pituitary-Adrenal System - drug effects</subject><subject>Pituitary-Adrenal System - metabolism</subject><subject>Proteins</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Serum levels</subject><subject>Stress, Psychological - drug therapy</subject><subject>Stress, Psychological - metabolism</subject><subject>Stress, Psychological - psychology</subject><subject>Sucrose</subject><subject>Sugar</subject><subject>Swimming</subject><subject>Treatment Outcome</subject><issn>0364-3190</issn><issn>1573-6903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kctuEzEUhkcIREPhAdggS2zYDPgy12UIKUEKF5WyHnns48TFsae2J0q66jv0nXgQngSnKSAhsTqWz_f_59h_lj0n-DXBuH4TCMFVkWPS5LSsqvz6QTYhZc3yqsXsYTbBLHUZafFJ9iSES4yTipLH2Qltm7JsimqS_Vg4675rZ9B8Bz4GNLVRSxg8hMBtRHOlQKRrbdE5T3W-G1wAiaJDs7V3Vgv0zSZaahF5bwB91Eair_GgR_0encNqNDxqu0JvPU8u78DrbTL4BKN30bthnSzOuIjOoyVswSBuJVrsBxfX3PDNGH7e3H7RcdSR-306T6UHyw2a7nTaVkS91XH_NHukuAnw7L6eZhdn84vZIl9-fv9hNl3momBNzGnfMEpACaBSCcoazLniuFYgVfoTUQAQWUrCK9Yyokpa11L0jDUAFSuBnWavjraDd1cjhNhtdBBgDLfgxtBRXLRlCoA1CX35D3rpRp8Wv6PqtqTkjiJHSngXggfVDV5v0kM7grtDxt0x4y5l3B0y7q6T5sW989hvQP5R_A41AfQIhNSyK_B_R__f9RejmLle</recordid><startdate>20180801</startdate><enddate>20180801</enddate><creator>Wang, Canmao</creator><creator>Gan, Danna</creator><creator>Wu, Jingang</creator><creator>Liao, Minhui</creator><creator>Liao, Xinghuan</creator><creator>Ai, Weipeng</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0057-9775</orcidid></search><sort><creationdate>20180801</creationdate><title>Honokiol Exerts Antidepressant Effects in Rats Exposed to Chronic Unpredictable Mild Stress by Regulating Brain Derived Neurotrophic Factor Level and Hypothalamus–Pituitary–Adrenal Axis Activity</title><author>Wang, Canmao ; Gan, Danna ; Wu, Jingang ; Liao, Minhui ; Liao, Xinghuan ; Ai, Weipeng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-2b8321efce2dfc2380aafa07fedf298c4ee1d5d1a63931f5277dcb338ee635e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adrenocorticotropic hormone</topic><topic>Animals</topic><topic>Antidepressants</topic><topic>Antidepressive Agents - therapeutic use</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Biphenyl Compounds - pharmacology</topic><topic>Biphenyl Compounds - therapeutic use</topic><topic>Brain</topic><topic>Brain-derived neurotrophic factor</topic><topic>Brain-Derived Neurotrophic Factor - metabolism</topic><topic>Cell Biology</topic><topic>Chronic Disease</topic><topic>Corticosterone</topic><topic>Corticotropin-releasing hormone</topic><topic>Dose-Response Relationship, Drug</topic><topic>Field tests</topic><topic>Gene expression</topic><topic>Glucocorticoids</topic><topic>Hippocampus</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - metabolism</topic><topic>Hyperactivity</topic><topic>Hypothalamic-pituitary-adrenal axis</topic><topic>Hypothalamo-Hypophyseal System - drug effects</topic><topic>Hypothalamo-Hypophyseal System - metabolism</topic><topic>Hypothalamus</topic><topic>Lignans - pharmacology</topic><topic>Lignans - therapeutic use</topic><topic>Male</topic><topic>mRNA</topic><topic>Neurochemistry</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Normalizing</topic><topic>Open-field behavior</topic><topic>Original Paper</topic><topic>Pharmacology</topic><topic>Pituitary</topic><topic>Pituitary-Adrenal System - drug effects</topic><topic>Pituitary-Adrenal System - metabolism</topic><topic>Proteins</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Serum levels</topic><topic>Stress, Psychological - drug therapy</topic><topic>Stress, Psychological - metabolism</topic><topic>Stress, Psychological - psychology</topic><topic>Sucrose</topic><topic>Sugar</topic><topic>Swimming</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Canmao</creatorcontrib><creatorcontrib>Gan, Danna</creatorcontrib><creatorcontrib>Wu, Jingang</creatorcontrib><creatorcontrib>Liao, Minhui</creatorcontrib><creatorcontrib>Liao, Xinghuan</creatorcontrib><creatorcontrib>Ai, Weipeng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Neurochemical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Canmao</au><au>Gan, Danna</au><au>Wu, Jingang</au><au>Liao, Minhui</au><au>Liao, Xinghuan</au><au>Ai, Weipeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Honokiol Exerts Antidepressant Effects in Rats Exposed to Chronic Unpredictable Mild Stress by Regulating Brain Derived Neurotrophic Factor Level and Hypothalamus–Pituitary–Adrenal Axis Activity</atitle><jtitle>Neurochemical research</jtitle><stitle>Neurochem Res</stitle><addtitle>Neurochem Res</addtitle><date>2018-08-01</date><risdate>2018</risdate><volume>43</volume><issue>8</issue><spage>1519</spage><epage>1528</epage><pages>1519-1528</pages><issn>0364-3190</issn><eissn>1573-6903</eissn><abstract>Honokiol (HNK), the main active component of
Magnolia officinalis
, has shown a variety of pharmacological activities. In the present study, we measured the antidepressant-like effects of HNK in a rat model of chronic unpredictable mild stress (CUMS) and explored its possible mechanisms. The antidepressant-like effects of HNK were assessed in rats by an open field test (OFT), sucrose preference test (SPT) and forced swimming test (FST). Then, serum levels of corticotrophin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH) and corticosterone (CORT) and hippocampal brain-derived neurotrophic factor (BDNF) and glucocorticoid receptor α (GRα) levels were assessed to explore the possible mechanisms. We identified that HNK treatment (2, 4, and 8 mg/kg) alleviated the CUMS-induced behavioural deficits. Treatment with HNK also normalized the CUMS-induced hyperactivity of the limbic hypothalamic–pituitary–adrenal (HPA) axis, as indicated by reduced CRH, ACTH and CORT serum levels. In addition, HNK increased the expression of GRα (mRNA and protein) and BDNF (mRNA and protein) in the hippocampus. These data confirmed the antidepressant-like effects of HNK, which may be related to its normalizing the function of the HPA axis and increasing the BDNF level in the hippocampus.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>29855846</pmid><doi>10.1007/s11064-018-2566-z</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-0057-9775</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0364-3190 |
| ispartof | Neurochemical research, 2018-08, Vol.43 (8), p.1519-1528 |
| issn | 0364-3190 1573-6903 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2049557338 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Adrenocorticotropic hormone Animals Antidepressants Antidepressive Agents - therapeutic use Biochemistry Biomedical and Life Sciences Biomedicine Biphenyl Compounds - pharmacology Biphenyl Compounds - therapeutic use Brain Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - metabolism Cell Biology Chronic Disease Corticosterone Corticotropin-releasing hormone Dose-Response Relationship, Drug Field tests Gene expression Glucocorticoids Hippocampus Hippocampus - drug effects Hippocampus - metabolism Hyperactivity Hypothalamic-pituitary-adrenal axis Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - metabolism Hypothalamus Lignans - pharmacology Lignans - therapeutic use Male mRNA Neurochemistry Neurology Neurosciences Normalizing Open-field behavior Original Paper Pharmacology Pituitary Pituitary-Adrenal System - drug effects Pituitary-Adrenal System - metabolism Proteins Rats Rats, Wistar Rodents Serum levels Stress, Psychological - drug therapy Stress, Psychological - metabolism Stress, Psychological - psychology Sucrose Sugar Swimming Treatment Outcome |
| title | Honokiol Exerts Antidepressant Effects in Rats Exposed to Chronic Unpredictable Mild Stress by Regulating Brain Derived Neurotrophic Factor Level and Hypothalamus–Pituitary–Adrenal Axis Activity |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T14%3A18%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Honokiol%20Exerts%20Antidepressant%20Effects%20in%20Rats%20Exposed%20to%20Chronic%20Unpredictable%20Mild%20Stress%20by%20Regulating%20Brain%20Derived%20Neurotrophic%20Factor%20Level%20and%20Hypothalamus%E2%80%93Pituitary%E2%80%93Adrenal%20Axis%20Activity&rft.jtitle=Neurochemical%20research&rft.au=Wang,%20Canmao&rft.date=2018-08-01&rft.volume=43&rft.issue=8&rft.spage=1519&rft.epage=1528&rft.pages=1519-1528&rft.issn=0364-3190&rft.eissn=1573-6903&rft_id=info:doi/10.1007/s11064-018-2566-z&rft_dat=%3Cproquest_cross%3E2049557338%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2047952138&rft_id=info:pmid/29855846&rfr_iscdi=true |