Polygonatum sibiricum rhizome promotes sleep by regulating non-rapid eye movement and GABAergic/serotonergic receptors in rodent models

[Display omitted] •PSE significantly reduced latency time and increased total sleep in mice.•PSE increased total sleep time by increasing NREM and decreasing REM in rat.•PSE effectively restores caffeine-induced sleep disturbance.•PSE showed sleep enhancement through GABAergic/serotonergic action.•G...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2018-09, Vol.105, p.167-175
Hauptverfasser:	Jo, Kyungae, Suh, Hyung Joo, Choi, Hyeon-Son
Format:	Artikel
Sprache:	eng
Schlagworte:	Caffeine Insomnia Polygonatum sibiricum Sleep Vertebrate γ-aminobutyric acid
Online-Zugang:	Volltext
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