Quantitative Translational Analysis of Brain Kynurenic Acid Modulation via Irreversible Kynurenine Aminotransferase II Inhibition

Kynurenic acid (KYNA) plays a significant role in maintaining normal brain function, and abnormalities in KYNA levels have been associated with various central nervous system disorders. Confirmation of its causality in human diseases requires safe and effective modulation of central KYNA levels in t...

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Veröffentlicht in:	Molecular pharmacology 2018-08, Vol.94 (2), p.823-833
Hauptverfasser:	Chang, Cheng, Fonseca, Kari R., Li, Cheryl, Horner, Weldon, Zawadzke, Laura E., Salafia, Michelle A., Welch, Kathryn A., Strick, Christine A., Campbell, Brian M., Gernhardt, Steve S., Rong, Haojing, Sawant-Basak, Aarti, Liras, Jennifer, Dounay, Amy, Tuttle, Jamison B., Verhoest, Patrick, Maurer, Tristan S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - metabolism Brain Chemistry - drug effects Cells, Cultured Chromatography, Liquid Enzyme Inhibitors - administration & dosage Enzyme Inhibitors - pharmacology Female Half-Life Humans Kynurenic Acid - analysis Macaca fascicularis Male Pyrazoles - administration & dosage Pyrazoles - pharmacology Rats Tandem Mass Spectrometry Transaminases - antagonists & inhibitors Transaminases - metabolism
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