“Biomimetic-electrochemical-sensory-platform” for biomolecule free cocaine testing
A biomimetic cocaine sensor was fabricated by using poly(p-phenylene) (PPP) with cyclodextrin (CD) units in the backbone and poly(ethylene glycol) (PEG) side chains (PPP-CD-g-PEG). The sensory platform was constructed by one step surface modification of glassy carbon electrode with PPP-CD-g-PEG by d...
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| Veröffentlicht in: | Materials Science & Engineering C 2018-09, Vol.90, p.211-218 |
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| creator | Yilmaz Sengel, Tulay Guler, Emine Arslan, Mustafa Gumus, Z. Pinar Sanli, Serdar Aldemir, Ebru Akbulut, Huseyin Odaci Demirkol, Dilek Coskunol, Hakan Timur, Suna Yagci, Yusuf |
| description | A biomimetic cocaine sensor was fabricated by using poly(p-phenylene) (PPP) with cyclodextrin (CD) units in the backbone and poly(ethylene glycol) (PEG) side chains (PPP-CD-g-PEG). The sensory platform was constructed by one step surface modification of glassy carbon electrode with PPP-CD-g-PEG by drop coating. The electrochemical measurements are based on the formation of CD-cocaine inclusion complex on the surface resulting in a significant decrease in electron transfer capacity of the selected redox probe. The changes in the surface features due to cocaine binding were explored via electrochemical techniques such as differential pulse voltammetry, cyclic voltammetry and electrochemical impedance spectrometry. The sensor exhibited linearity in the range of 25–200 nM cocaine, LOD was calculated as 28.62 nM (n = 5) according to 3Sb/m formula. Finally, the sensory platform was successfully applied for the cocaine analysis in synthetic urine samples and correlated with the chromatographic method.
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•A biomimetic cocaine sensor was fabricated by using poly(p-phenylene) containing β-CD and PEG side chains.•Excellent combination of properties of different functionalities resulted in a biomimetic platform for cocaine recognition.•Biomimetic-Electrochemical-Sensory-Platform’ for biomolecule free drug testing. |
| doi_str_mv | 10.1016/j.msec.2018.04.043 |
| format | Article |
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[Display omitted]
•A biomimetic cocaine sensor was fabricated by using poly(p-phenylene) containing β-CD and PEG side chains.•Excellent combination of properties of different functionalities resulted in a biomimetic platform for cocaine recognition.•Biomimetic-Electrochemical-Sensory-Platform’ for biomolecule free drug testing.</description><identifier>ISSN: 0928-4931</identifier><identifier>EISSN: 1873-0191</identifier><identifier>DOI: 10.1016/j.msec.2018.04.043</identifier><identifier>PMID: 29853084</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>beta-Cyclodextrins - chemistry ; Biomimetic material ; Biomimetics ; Carbon ; Chromatography ; Coated electrodes ; Cocaine ; Cocaine - chemistry ; Cocaine testing ; Cyclodextrin ; Cyclodextrins ; Electrochemical sensor ; Electrochemical Techniques - methods ; Electrochemistry ; Electrodes ; Electron transfer ; Glassy carbon ; Linearity ; Materials science ; Molecules ; Nanotubes, Carbon - chemistry ; Polyethylene glycol ; Spectrometry ; Testing ; Urine ; Voltammetry</subject><ispartof>Materials Science & Engineering C, 2018-09, Vol.90, p.211-218</ispartof><rights>2018 Elsevier B.V.</rights><rights>Copyright © 2018 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier BV Sep 1, 2018</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-5e988448c3de287ba01b73141b104df90795861ca6f937f4969220e1394a18fd3</citedby><cites>FETCH-LOGICAL-c384t-5e988448c3de287ba01b73141b104df90795861ca6f937f4969220e1394a18fd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0928493117333799$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29853084$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yilmaz Sengel, Tulay</creatorcontrib><creatorcontrib>Guler, Emine</creatorcontrib><creatorcontrib>Arslan, Mustafa</creatorcontrib><creatorcontrib>Gumus, Z. Pinar</creatorcontrib><creatorcontrib>Sanli, Serdar</creatorcontrib><creatorcontrib>Aldemir, Ebru</creatorcontrib><creatorcontrib>Akbulut, Huseyin</creatorcontrib><creatorcontrib>Odaci Demirkol, Dilek</creatorcontrib><creatorcontrib>Coskunol, Hakan</creatorcontrib><creatorcontrib>Timur, Suna</creatorcontrib><creatorcontrib>Yagci, Yusuf</creatorcontrib><title>“Biomimetic-electrochemical-sensory-platform” for biomolecule free cocaine testing</title><title>Materials Science & Engineering C</title><addtitle>Mater Sci Eng C Mater Biol Appl</addtitle><description>A biomimetic cocaine sensor was fabricated by using poly(p-phenylene) (PPP) with cyclodextrin (CD) units in the backbone and poly(ethylene glycol) (PEG) side chains (PPP-CD-g-PEG). The sensory platform was constructed by one step surface modification of glassy carbon electrode with PPP-CD-g-PEG by drop coating. The electrochemical measurements are based on the formation of CD-cocaine inclusion complex on the surface resulting in a significant decrease in electron transfer capacity of the selected redox probe. The changes in the surface features due to cocaine binding were explored via electrochemical techniques such as differential pulse voltammetry, cyclic voltammetry and electrochemical impedance spectrometry. The sensor exhibited linearity in the range of 25–200 nM cocaine, LOD was calculated as 28.62 nM (n = 5) according to 3Sb/m formula. Finally, the sensory platform was successfully applied for the cocaine analysis in synthetic urine samples and correlated with the chromatographic method.
[Display omitted]
•A biomimetic cocaine sensor was fabricated by using poly(p-phenylene) containing β-CD and PEG side chains.•Excellent combination of properties of different functionalities resulted in a biomimetic platform for cocaine recognition.•Biomimetic-Electrochemical-Sensory-Platform’ for biomolecule free drug testing.</description><subject>beta-Cyclodextrins - chemistry</subject><subject>Biomimetic material</subject><subject>Biomimetics</subject><subject>Carbon</subject><subject>Chromatography</subject><subject>Coated electrodes</subject><subject>Cocaine</subject><subject>Cocaine - chemistry</subject><subject>Cocaine testing</subject><subject>Cyclodextrin</subject><subject>Cyclodextrins</subject><subject>Electrochemical sensor</subject><subject>Electrochemical Techniques - methods</subject><subject>Electrochemistry</subject><subject>Electrodes</subject><subject>Electron transfer</subject><subject>Glassy carbon</subject><subject>Linearity</subject><subject>Materials science</subject><subject>Molecules</subject><subject>Nanotubes, Carbon - chemistry</subject><subject>Polyethylene glycol</subject><subject>Spectrometry</subject><subject>Testing</subject><subject>Urine</subject><subject>Voltammetry</subject><issn>0928-4931</issn><issn>1873-0191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtO3DAUhq2KCgbKC3RRRWLTTYbjSxJbYgOoXCSkbqBby3FOWo-SeGonSLPjQeDleBIczbQLFkhHOpvv_8_RR8hXCksKtDxdLfuIdsmAyiWINPwTWVBZ8RyoontkAYrJXChOD8hhjCuAUvKK7ZMDpmTBQYoF-fX69HzhfO96HJ3NsUM7Bm__YO-s6fKIQ_Rhk687M7Y-9K9PL1naWZ0iPrFTh1kbEDPrrXEDZiPG0Q2_v5DPrekiHu_2EXm4-nF_eZPf_by-vTy_yy2XYswLVFIKIS1vkMmqNkDrilNBawqiaRVUqpAltaZsFa9aoUrFGCDlShgq24Yfke_b3nXwf6d0W_cuWuw6M6CfomYgVFEwXpUJPXmHrvwUhvRdoqRMl4DNFNtSNvgYA7Z6HVxvwkZT0LN1vdKzdT1b1yDS8BT6tque6h6b_5F_mhNwtgUwuXh0GHS0DgeLjQtJuG68-6j_DXMflIk</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>Yilmaz Sengel, Tulay</creator><creator>Guler, Emine</creator><creator>Arslan, Mustafa</creator><creator>Gumus, Z. 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Pinar</au><au>Sanli, Serdar</au><au>Aldemir, Ebru</au><au>Akbulut, Huseyin</au><au>Odaci Demirkol, Dilek</au><au>Coskunol, Hakan</au><au>Timur, Suna</au><au>Yagci, Yusuf</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>“Biomimetic-electrochemical-sensory-platform” for biomolecule free cocaine testing</atitle><jtitle>Materials Science & Engineering C</jtitle><addtitle>Mater Sci Eng C Mater Biol Appl</addtitle><date>2018-09-01</date><risdate>2018</risdate><volume>90</volume><spage>211</spage><epage>218</epage><pages>211-218</pages><issn>0928-4931</issn><eissn>1873-0191</eissn><abstract>A biomimetic cocaine sensor was fabricated by using poly(p-phenylene) (PPP) with cyclodextrin (CD) units in the backbone and poly(ethylene glycol) (PEG) side chains (PPP-CD-g-PEG). The sensory platform was constructed by one step surface modification of glassy carbon electrode with PPP-CD-g-PEG by drop coating. The electrochemical measurements are based on the formation of CD-cocaine inclusion complex on the surface resulting in a significant decrease in electron transfer capacity of the selected redox probe. The changes in the surface features due to cocaine binding were explored via electrochemical techniques such as differential pulse voltammetry, cyclic voltammetry and electrochemical impedance spectrometry. The sensor exhibited linearity in the range of 25–200 nM cocaine, LOD was calculated as 28.62 nM (n = 5) according to 3Sb/m formula. Finally, the sensory platform was successfully applied for the cocaine analysis in synthetic urine samples and correlated with the chromatographic method.
[Display omitted]
•A biomimetic cocaine sensor was fabricated by using poly(p-phenylene) containing β-CD and PEG side chains.•Excellent combination of properties of different functionalities resulted in a biomimetic platform for cocaine recognition.•Biomimetic-Electrochemical-Sensory-Platform’ for biomolecule free drug testing.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>29853084</pmid><doi>10.1016/j.msec.2018.04.043</doi><tpages>8</tpages></addata></record> |
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| subjects | beta-Cyclodextrins - chemistry Biomimetic material Biomimetics Carbon Chromatography Coated electrodes Cocaine Cocaine - chemistry Cocaine testing Cyclodextrin Cyclodextrins Electrochemical sensor Electrochemical Techniques - methods Electrochemistry Electrodes Electron transfer Glassy carbon Linearity Materials science Molecules Nanotubes, Carbon - chemistry Polyethylene glycol Spectrometry Testing Urine Voltammetry |
| title | “Biomimetic-electrochemical-sensory-platform” for biomolecule free cocaine testing |
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