Doxorubicin Conjugation and Drug Linker Chemistry Alter the Intravenous and Pulmonary Pharmacokinetics of a PEGylated Generation 4 Polylysine Dendrimer in Rats

PEGylated polylysine dendrimers have demonstrated potential as inhalable drug delivery systems that can improve the treatment of lung cancers. Their treatment potential may be enhanced by developing constructs that display prolonged lung retention, together with good systemic absorption, the capacit...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2018-09, Vol.107 (9), p.2509-2513
Hauptverfasser:	Leong, Nathania J., Mehta, Dharmini, McLeod, Victoria M., Kelly, Brian D., Pathak, Rashmi, Owen, David J., Porter, Christopher J.H., Kaminskas, Lisa M.
Format:	Artikel
Sprache:	eng
Schlagworte:	cathepsin B dendrimer doxorubicin lung clearance pharmacokinetics pulmonary
Online-Zugang:	Volltext
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