Protective effect of benzothiazole derivative KHG21834 on amyloid β-induced neurotoxicity in PC12 cells and cortical and mesencephalic neurons

Abstract We have investigated the effect of KHG21834, a benzothiazole derivative, on the amyloid beta protein (Aβ)-induced cell death in rat pheochromocytoma (PC12) cells and rat cortical and mesencephalic neuron-glia cultures. KHG21834 attenuated the Aβ25-35 -induced apoptotic death in PC12 cells d...

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Veröffentlicht in:	Toxicology (Amsterdam) 2007-10, Vol.239 (3), p.156-166
Hauptverfasser:	Choi, Myung-Min, Kim, Eun-A, Hahn, Hoh-Gyu, Dal Nam, Kee, Yang, Seung-Ju, Choi, Soo Young, Kim, Tae Ue, Cho, Sung-Woo, Huh, Jae-Wan
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta Amyloid beta-Peptides - toxicity Animals Antibodies - immunology Apoptosis - drug effects Benzothiazoles - chemistry Benzothiazoles - pharmacology Biological and medical sciences Blotting, Western Cell Survival - drug effects Cells, Cultured Cerebral Cortex - drug effects Cerebral Cortex - metabolism Cerebral Cortex - pathology Cortical neurons DNA Fragmentation - drug effects Emergency ERK Immunohistochemistry In Situ Nick-End Labeling KHG21834 Medical sciences Mesencephalic neurons Mesencephalon - drug effects Mesencephalon - metabolism Mesencephalon - pathology Microscopy, Confocal Microscopy, Fluorescence Mitogen-Activated Protein Kinase 3 - metabolism Molecular Structure Neurons - drug effects Neurons - metabolism Neurons - pathology Neuroprotective Agents - chemistry Neuroprotective Agents - pharmacology PC12 Cells Peptide Fragments - toxicity Rats Rats, Sprague-Dawley Toxicology Tyrosine 3-Monooxygenase - immunology Tyrosine 3-Monooxygenase - metabolism
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