Quantitative Trait Loci Determining Weight Reduction of Testes and Pituitary by Diethylstilbesterol in LEXF and FXLE Recombinant Inbred Strain Rats
Increasing exposure to environmental endocrine disruptor, xeno-estrogen, is a serious hazard to male reproductive activity. To explore possible genetic control in susceptibility to xeno-estrogen, the weight reduction of testes induced by the continuous administration of a synthetic estrogen, diethyl...
Gespeichert in:
| Veröffentlicht in: | Experimental Animals 2006, Vol.55(2), pp.91-95 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 95 |
|---|---|
| container_issue | 2 |
| container_start_page | 91 |
| container_title | Experimental Animals |
| container_volume | 55 |
| creator | TACHIBANA, Masayoshi LU, Lingmin HIAI, Hiroshi TAMURA, Atsushi MATSUSHIMA, Yoshibumi SHISA, Hayase |
| description | Increasing exposure to environmental endocrine disruptor, xeno-estrogen, is a serious hazard to male reproductive activity. To explore possible genetic control in susceptibility to xeno-estrogen, the weight reduction of testes induced by the continuous administration of a synthetic estrogen, diethylstilbesterol, were investigated by quantitative trait analysis in LEXF and FXLE recombinant inbred strain rats, consisting of 21 independent strains, 9 of their substrains, parental F344/Stm and LE/Stm strains, and (F344 × LE)F1. For the weight of testes, one highly significant quantitative trait locus (QTL) and one significant QTL were mapped on chromosomes 7 and 1, respectively. The QTL on chromosome 7 is closely associated with c-myc. Pituitary weight and serum prolactin were also variable among recombinant inbred strains, but no QTL was detected for them in this study. |
| doi_str_mv | 10.1538/expanim.55.91 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_20485836</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20485836</sourcerecordid><originalsourceid>FETCH-LOGICAL-c592t-99a954d0f6dd33fd7b76ce19b1b9cce1dc1a4ba6c4530df667c63983bf57a7ff3</originalsourceid><addsrcrecordid>eNpNkU1v1DAQhiNERUvhyBX5xC1LHMd2fIR2FypFKm0X0Vvkj_Guq8TZ2g5ifwd_GJddFS72SH70zIzfoniHqwWmpP0Iv3bSu3FB6ULgF8UZbltcclzXL3NNGlxiQvlp8TrGh6qqOa_Fq-IUM0YxE_is-H0zS59cksn9BLQO0iXUTdqhS0gQRued36Af4DbbhG7BzDq5yaPJojXEBBFJb9A3l-ZsCHuk9ujSQdruh5jcoJ6QMA3IedQt71d_4dV9t8wmPY3K-dwaXXkVwKC7lHt7dCtTfFOcWDlEeHu8z4vvq-X64mvZXX-5uvjUlZqKOpVCSEEbU1lmDCHWcMWZBiwUVkLnwmgsGyWZbiipjGWMa0ZES5SlXHJryXnx4eDdhelxzsP2o4sahkF6mObY11XT0pawDJYHUIcpxgC23wU35oV7XPVPKfTHFHpKe4Ez__4ontUI5h99_PYMfD4ADzHJDTwDMiSnB_hfVx8OgZ8f9VaGHjz5A1fEoEk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20485836</pqid></control><display><type>article</type><title>Quantitative Trait Loci Determining Weight Reduction of Testes and Pituitary by Diethylstilbesterol in LEXF and FXLE Recombinant Inbred Strain Rats</title><source>MEDLINE</source><source>J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>TACHIBANA, Masayoshi ; LU, Lingmin ; HIAI, Hiroshi ; TAMURA, Atsushi ; MATSUSHIMA, Yoshibumi ; SHISA, Hayase</creator><creatorcontrib>TACHIBANA, Masayoshi ; LU, Lingmin ; HIAI, Hiroshi ; TAMURA, Atsushi ; MATSUSHIMA, Yoshibumi ; SHISA, Hayase</creatorcontrib><description>Increasing exposure to environmental endocrine disruptor, xeno-estrogen, is a serious hazard to male reproductive activity. To explore possible genetic control in susceptibility to xeno-estrogen, the weight reduction of testes induced by the continuous administration of a synthetic estrogen, diethylstilbesterol, were investigated by quantitative trait analysis in LEXF and FXLE recombinant inbred strain rats, consisting of 21 independent strains, 9 of their substrains, parental F344/Stm and LE/Stm strains, and (F344 × LE)F1. For the weight of testes, one highly significant quantitative trait locus (QTL) and one significant QTL were mapped on chromosomes 7 and 1, respectively. The QTL on chromosome 7 is closely associated with c-myc. Pituitary weight and serum prolactin were also variable among recombinant inbred strains, but no QTL was detected for them in this study.</description><identifier>ISSN: 1341-1357</identifier><identifier>EISSN: 1881-7122</identifier><identifier>DOI: 10.1538/expanim.55.91</identifier><identifier>PMID: 16651691</identifier><language>eng</language><publisher>Japan: Japanese Association for Laboratory Animal Science</publisher><subject>Animals ; Chromosome Mapping ; Diethylstilbestrol - toxicity ; diethystilbesterol ; Endocrine Disruptors - toxicity ; LEXF and FXLE rat ; Male ; Organ Size - drug effects ; Pituitary Gland - drug effects ; Prolactin - blood ; QTL ; Rats ; Rats, Inbred Strains - genetics ; recombinant inbred strain ; Recombination, Genetic ; testis ; Testis - drug effects</subject><ispartof>Experimental Animals, 2006, Vol.55(2), pp.91-95</ispartof><rights>2006 Japanese Association for Laboratory Animal Science</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c592t-99a954d0f6dd33fd7b76ce19b1b9cce1dc1a4ba6c4530df667c63983bf57a7ff3</citedby><cites>FETCH-LOGICAL-c592t-99a954d0f6dd33fd7b76ce19b1b9cce1dc1a4ba6c4530df667c63983bf57a7ff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1884,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16651691$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TACHIBANA, Masayoshi</creatorcontrib><creatorcontrib>LU, Lingmin</creatorcontrib><creatorcontrib>HIAI, Hiroshi</creatorcontrib><creatorcontrib>TAMURA, Atsushi</creatorcontrib><creatorcontrib>MATSUSHIMA, Yoshibumi</creatorcontrib><creatorcontrib>SHISA, Hayase</creatorcontrib><title>Quantitative Trait Loci Determining Weight Reduction of Testes and Pituitary by Diethylstilbesterol in LEXF and FXLE Recombinant Inbred Strain Rats</title><title>Experimental Animals</title><addtitle>Exp Anim</addtitle><description>Increasing exposure to environmental endocrine disruptor, xeno-estrogen, is a serious hazard to male reproductive activity. To explore possible genetic control in susceptibility to xeno-estrogen, the weight reduction of testes induced by the continuous administration of a synthetic estrogen, diethylstilbesterol, were investigated by quantitative trait analysis in LEXF and FXLE recombinant inbred strain rats, consisting of 21 independent strains, 9 of their substrains, parental F344/Stm and LE/Stm strains, and (F344 × LE)F1. For the weight of testes, one highly significant quantitative trait locus (QTL) and one significant QTL were mapped on chromosomes 7 and 1, respectively. The QTL on chromosome 7 is closely associated with c-myc. Pituitary weight and serum prolactin were also variable among recombinant inbred strains, but no QTL was detected for them in this study.</description><subject>Animals</subject><subject>Chromosome Mapping</subject><subject>Diethylstilbestrol - toxicity</subject><subject>diethystilbesterol</subject><subject>Endocrine Disruptors - toxicity</subject><subject>LEXF and FXLE rat</subject><subject>Male</subject><subject>Organ Size - drug effects</subject><subject>Pituitary Gland - drug effects</subject><subject>Prolactin - blood</subject><subject>QTL</subject><subject>Rats</subject><subject>Rats, Inbred Strains - genetics</subject><subject>recombinant inbred strain</subject><subject>Recombination, Genetic</subject><subject>testis</subject><subject>Testis - drug effects</subject><issn>1341-1357</issn><issn>1881-7122</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkU1v1DAQhiNERUvhyBX5xC1LHMd2fIR2FypFKm0X0Vvkj_Guq8TZ2g5ifwd_GJddFS72SH70zIzfoniHqwWmpP0Iv3bSu3FB6ULgF8UZbltcclzXL3NNGlxiQvlp8TrGh6qqOa_Fq-IUM0YxE_is-H0zS59cksn9BLQO0iXUTdqhS0gQRued36Af4DbbhG7BzDq5yaPJojXEBBFJb9A3l-ZsCHuk9ujSQdruh5jcoJ6QMA3IedQt71d_4dV9t8wmPY3K-dwaXXkVwKC7lHt7dCtTfFOcWDlEeHu8z4vvq-X64mvZXX-5uvjUlZqKOpVCSEEbU1lmDCHWcMWZBiwUVkLnwmgsGyWZbiipjGWMa0ZES5SlXHJryXnx4eDdhelxzsP2o4sahkF6mObY11XT0pawDJYHUIcpxgC23wU35oV7XPVPKfTHFHpKe4Ez__4ontUI5h99_PYMfD4ADzHJDTwDMiSnB_hfVx8OgZ8f9VaGHjz5A1fEoEk</recordid><startdate>20060401</startdate><enddate>20060401</enddate><creator>TACHIBANA, Masayoshi</creator><creator>LU, Lingmin</creator><creator>HIAI, Hiroshi</creator><creator>TAMURA, Atsushi</creator><creator>MATSUSHIMA, Yoshibumi</creator><creator>SHISA, Hayase</creator><general>Japanese Association for Laboratory Animal Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20060401</creationdate><title>Quantitative Trait Loci Determining Weight Reduction of Testes and Pituitary by Diethylstilbesterol in LEXF and FXLE Recombinant Inbred Strain Rats</title><author>TACHIBANA, Masayoshi ; LU, Lingmin ; HIAI, Hiroshi ; TAMURA, Atsushi ; MATSUSHIMA, Yoshibumi ; SHISA, Hayase</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c592t-99a954d0f6dd33fd7b76ce19b1b9cce1dc1a4ba6c4530df667c63983bf57a7ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Chromosome Mapping</topic><topic>Diethylstilbestrol - toxicity</topic><topic>diethystilbesterol</topic><topic>Endocrine Disruptors - toxicity</topic><topic>LEXF and FXLE rat</topic><topic>Male</topic><topic>Organ Size - drug effects</topic><topic>Pituitary Gland - drug effects</topic><topic>Prolactin - blood</topic><topic>QTL</topic><topic>Rats</topic><topic>Rats, Inbred Strains - genetics</topic><topic>recombinant inbred strain</topic><topic>Recombination, Genetic</topic><topic>testis</topic><topic>Testis - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TACHIBANA, Masayoshi</creatorcontrib><creatorcontrib>LU, Lingmin</creatorcontrib><creatorcontrib>HIAI, Hiroshi</creatorcontrib><creatorcontrib>TAMURA, Atsushi</creatorcontrib><creatorcontrib>MATSUSHIMA, Yoshibumi</creatorcontrib><creatorcontrib>SHISA, Hayase</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Experimental Animals</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TACHIBANA, Masayoshi</au><au>LU, Lingmin</au><au>HIAI, Hiroshi</au><au>TAMURA, Atsushi</au><au>MATSUSHIMA, Yoshibumi</au><au>SHISA, Hayase</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative Trait Loci Determining Weight Reduction of Testes and Pituitary by Diethylstilbesterol in LEXF and FXLE Recombinant Inbred Strain Rats</atitle><jtitle>Experimental Animals</jtitle><addtitle>Exp Anim</addtitle><date>2006-04-01</date><risdate>2006</risdate><volume>55</volume><issue>2</issue><spage>91</spage><epage>95</epage><pages>91-95</pages><issn>1341-1357</issn><eissn>1881-7122</eissn><abstract>Increasing exposure to environmental endocrine disruptor, xeno-estrogen, is a serious hazard to male reproductive activity. To explore possible genetic control in susceptibility to xeno-estrogen, the weight reduction of testes induced by the continuous administration of a synthetic estrogen, diethylstilbesterol, were investigated by quantitative trait analysis in LEXF and FXLE recombinant inbred strain rats, consisting of 21 independent strains, 9 of their substrains, parental F344/Stm and LE/Stm strains, and (F344 × LE)F1. For the weight of testes, one highly significant quantitative trait locus (QTL) and one significant QTL were mapped on chromosomes 7 and 1, respectively. The QTL on chromosome 7 is closely associated with c-myc. Pituitary weight and serum prolactin were also variable among recombinant inbred strains, but no QTL was detected for them in this study.</abstract><cop>Japan</cop><pub>Japanese Association for Laboratory Animal Science</pub><pmid>16651691</pmid><doi>10.1538/expanim.55.91</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1341-1357 |
| ispartof | Experimental Animals, 2006, Vol.55(2), pp.91-95 |
| issn | 1341-1357 1881-7122 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_20485836 |
| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Chromosome Mapping Diethylstilbestrol - toxicity diethystilbesterol Endocrine Disruptors - toxicity LEXF and FXLE rat Male Organ Size - drug effects Pituitary Gland - drug effects Prolactin - blood QTL Rats Rats, Inbred Strains - genetics recombinant inbred strain Recombination, Genetic testis Testis - drug effects |
| title | Quantitative Trait Loci Determining Weight Reduction of Testes and Pituitary by Diethylstilbesterol in LEXF and FXLE Recombinant Inbred Strain Rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-13T07%3A52%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Quantitative%20Trait%20Loci%20Determining%20Weight%20Reduction%20of%20Testes%20and%20Pituitary%20by%20Diethylstilbesterol%20in%20LEXF%20and%20FXLE%20Recombinant%20Inbred%20Strain%20Rats&rft.jtitle=Experimental%20Animals&rft.au=TACHIBANA,%20Masayoshi&rft.date=2006-04-01&rft.volume=55&rft.issue=2&rft.spage=91&rft.epage=95&rft.pages=91-95&rft.issn=1341-1357&rft.eissn=1881-7122&rft_id=info:doi/10.1538/expanim.55.91&rft_dat=%3Cproquest_cross%3E20485836%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=20485836&rft_id=info:pmid/16651691&rfr_iscdi=true |