Immune heparin‐induced thrombocytopenia resulting from preceding exposure to heparin catheter flushes
Immune heparin‐induced thrombocytopenia (HIT) is a life‐threatening adverse effect of heparin. It can result from any type of heparin exposure and by any route of administration; however only a few cases are reported after exposures to small quantities of heparin from catheter flushes. The major cli...
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| Veröffentlicht in: | American journal of hematology 2007-07, Vol.82 (7), p.652-655 |
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| container_title | American journal of hematology |
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| creator | Muslimani, Alaa A. Ricaurte, Basma Daw, Hamed A. |
| description | Immune heparin‐induced thrombocytopenia (HIT) is a life‐threatening adverse effect of heparin. It can result from any type of heparin exposure and by any route of administration; however only a few cases are reported after exposures to small quantities of heparin from catheter flushes. The major clinical problem associated with HIT is thrombosis. Early detection and institution of alternative, non‐heparin anticoagulation are important. We report a patient with HIT associated with use of therapeutic‐dose unfractionated heparin in whom immune sensitization to heparin was triggered by two 500‐unit exposure to UFH associated with intravascular catheter flushing for antineoplastic chemotherapy in a patient with colon adenocarcinoma. Am. J. Hematol. 82: 2007. © 2006 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ajh.20849 |
| format | Article |
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It can result from any type of heparin exposure and by any route of administration; however only a few cases are reported after exposures to small quantities of heparin from catheter flushes. The major clinical problem associated with HIT is thrombosis. Early detection and institution of alternative, non‐heparin anticoagulation are important. We report a patient with HIT associated with use of therapeutic‐dose unfractionated heparin in whom immune sensitization to heparin was triggered by two 500‐unit exposure to UFH associated with intravascular catheter flushing for antineoplastic chemotherapy in a patient with colon adenocarcinoma. Am. J. Hematol. 82: 2007. © 2006 Wiley‐Liss, Inc.</description><identifier>ISSN: 0361-8609</identifier><identifier>EISSN: 1096-8652</identifier><identifier>DOI: 10.1002/ajh.20849</identifier><identifier>PMID: 17177192</identifier><identifier>CODEN: AJHEDD</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Biological and medical sciences ; Catheterization ; Female ; Hematologic and hematopoietic diseases ; Heparin - immunology ; Heparin - pharmacology ; heparin catheter flashes ; Humans ; Medical sciences ; Mesenteric Veins - pathology ; Middle Aged ; Platelet Count ; rapid‐onset heparin induced thrombocytopenia ; Thrombocytopenia - chemically induced ; Thrombocytopenia - immunology ; Thrombocytopenia - pathology ; Time Factors ; Tomography, X-Ray Computed</subject><ispartof>American journal of hematology, 2007-07, Vol.82 (7), p.652-655</ispartof><rights>Copyright © 2006 Wiley‐Liss, Inc.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4859-201ee4d4902bc0318e195c297c9a9f609ceb2d70434b75e8b5cf0f63fba42d773</citedby><cites>FETCH-LOGICAL-c4859-201ee4d4902bc0318e195c297c9a9f609ceb2d70434b75e8b5cf0f63fba42d773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fajh.20849$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fajh.20849$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,1434,27929,27930,45579,45580,46414,46838</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18868430$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17177192$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Muslimani, Alaa A.</creatorcontrib><creatorcontrib>Ricaurte, Basma</creatorcontrib><creatorcontrib>Daw, Hamed A.</creatorcontrib><title>Immune heparin‐induced thrombocytopenia resulting from preceding exposure to heparin catheter flushes</title><title>American journal of hematology</title><addtitle>Am J Hematol</addtitle><description>Immune heparin‐induced thrombocytopenia (HIT) is a life‐threatening adverse effect of heparin. It can result from any type of heparin exposure and by any route of administration; however only a few cases are reported after exposures to small quantities of heparin from catheter flushes. The major clinical problem associated with HIT is thrombosis. Early detection and institution of alternative, non‐heparin anticoagulation are important. We report a patient with HIT associated with use of therapeutic‐dose unfractionated heparin in whom immune sensitization to heparin was triggered by two 500‐unit exposure to UFH associated with intravascular catheter flushing for antineoplastic chemotherapy in a patient with colon adenocarcinoma. Am. J. Hematol. 82: 2007. © 2006 Wiley‐Liss, Inc.</description><subject>Biological and medical sciences</subject><subject>Catheterization</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Heparin - immunology</subject><subject>Heparin - pharmacology</subject><subject>heparin catheter flashes</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Mesenteric Veins - pathology</subject><subject>Middle Aged</subject><subject>Platelet Count</subject><subject>rapid‐onset heparin induced thrombocytopenia</subject><subject>Thrombocytopenia - chemically induced</subject><subject>Thrombocytopenia - immunology</subject><subject>Thrombocytopenia - pathology</subject><subject>Time Factors</subject><subject>Tomography, X-Ray Computed</subject><issn>0361-8609</issn><issn>1096-8652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10MtKxDAUBuAgijNeFr6AdKPgonqSpm2ylEEdRXCj65KmJ7ZDbyYtOjsfwWf0SYxOxZWr3D7OT35CjiicUwB2oVblOQPB5RaZU5BJKJKYbZM5RAn1e5AzsufcCoBSLmCXzGhK05RKNifPt00zthiU2CtbtZ_vH1VbjBqLYCht1-SdXg9dj22lAoturIeqfQ6Mfwl6i559H_Gt79xoMRi63zmBVkOJA9rA1KMr0R2QHaNqh4fTuk-erq8eF8vw_uHmdnF5H2ouYhkyoIi84BJYriGiAqmMNZOplkoa_xONOStS4BHP0xhFHmsDJolMrri_T6N9crqZ29vuZUQ3ZE3lNNa1arEbXcbA5ySSeXi2gdp2zlk0WW-rRtl1RiH7bjXzrWY_rXp7PA0d8waLPznV6MHJBJTTqjZWtbpyf06IRPAIvLvYuNeqxvX_idnl3XIT_QUDlZEz</recordid><startdate>200707</startdate><enddate>200707</enddate><creator>Muslimani, Alaa A.</creator><creator>Ricaurte, Basma</creator><creator>Daw, Hamed A.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>200707</creationdate><title>Immune heparin‐induced thrombocytopenia resulting from preceding exposure to heparin catheter flushes</title><author>Muslimani, Alaa A. ; Ricaurte, Basma ; Daw, Hamed A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4859-201ee4d4902bc0318e195c297c9a9f609ceb2d70434b75e8b5cf0f63fba42d773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Biological and medical sciences</topic><topic>Catheterization</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Heparin - immunology</topic><topic>Heparin - pharmacology</topic><topic>heparin catheter flashes</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Mesenteric Veins - pathology</topic><topic>Middle Aged</topic><topic>Platelet Count</topic><topic>rapid‐onset heparin induced thrombocytopenia</topic><topic>Thrombocytopenia - chemically induced</topic><topic>Thrombocytopenia - immunology</topic><topic>Thrombocytopenia - pathology</topic><topic>Time Factors</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Muslimani, Alaa A.</creatorcontrib><creatorcontrib>Ricaurte, Basma</creatorcontrib><creatorcontrib>Daw, Hamed A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>American journal of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muslimani, Alaa A.</au><au>Ricaurte, Basma</au><au>Daw, Hamed A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immune heparin‐induced thrombocytopenia resulting from preceding exposure to heparin catheter flushes</atitle><jtitle>American journal of hematology</jtitle><addtitle>Am J Hematol</addtitle><date>2007-07</date><risdate>2007</risdate><volume>82</volume><issue>7</issue><spage>652</spage><epage>655</epage><pages>652-655</pages><issn>0361-8609</issn><eissn>1096-8652</eissn><coden>AJHEDD</coden><abstract>Immune heparin‐induced thrombocytopenia (HIT) is a life‐threatening adverse effect of heparin. It can result from any type of heparin exposure and by any route of administration; however only a few cases are reported after exposures to small quantities of heparin from catheter flushes. The major clinical problem associated with HIT is thrombosis. Early detection and institution of alternative, non‐heparin anticoagulation are important. We report a patient with HIT associated with use of therapeutic‐dose unfractionated heparin in whom immune sensitization to heparin was triggered by two 500‐unit exposure to UFH associated with intravascular catheter flushing for antineoplastic chemotherapy in a patient with colon adenocarcinoma. Am. J. Hematol. 82: 2007. © 2006 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>17177192</pmid><doi>10.1002/ajh.20849</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Access via Wiley Online Library; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection) |
| subjects | Biological and medical sciences Catheterization Female Hematologic and hematopoietic diseases Heparin - immunology Heparin - pharmacology heparin catheter flashes Humans Medical sciences Mesenteric Veins - pathology Middle Aged Platelet Count rapid‐onset heparin induced thrombocytopenia Thrombocytopenia - chemically induced Thrombocytopenia - immunology Thrombocytopenia - pathology Time Factors Tomography, X-Ray Computed |
| title | Immune heparin‐induced thrombocytopenia resulting from preceding exposure to heparin catheter flushes |
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