2,3,7,8-TCDD exposure, endothelial dysfunction and impaired microvascular reactivity
Vascular function was examined in subjects with long-term high level of serum 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) during their follow-up visits. Their earlier mean peak TCDD level at the time of exposure in 1965—1968 was estimated in the range of 3300—74 000 pg/g lipids. Ten former pesticide...
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| creator | Pelclová, Daniela Prázný, Martin Škrha, Jan Fenclová, Zdenka Kalousová, Marta Urban, Pavel Navrátil, Tomáš Šenholdová, Zdenka Šmerhovský, Zdeněk |
| description | Vascular function was examined in subjects with long-term high level of serum 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) during their follow-up visits. Their earlier mean peak TCDD level at the time of exposure in 1965—1968 was estimated in the range of 3300—74 000 pg/g lipids. Ten former pesticide production workers heavily exposed to TCDD (age 57 ± 2 years, TCDD about 170 pg/g lipids) were examined in 2001. Extended group of 15 TCDD-exposed men (age 59 ± 3 years, TCDD about 130 pg/g lipids) underwent the same examination in 2004. Findings were compared with a control group of 14 healthy men (age 54 ± 2 years). Skin microvascular reactivity (MVR) was measured by laser Doppler perfusion monitoring in the forearm during post-occlusive reactive hyperemia (PORH) and thermal hyperemia (TH). Several parameters of MVR in men exposed to TCDD were significantly impaired, compared with the control group and further progression of the impairment of MVR has been observed between years 2001 and 2004. Serum concentration of E-selectin and inhibitor of tissue plasminogen activator 1 (PAI-1) was significantly higher in exposed subjects (56.0 ± 18.4 ng/mL versus 40.0 ± 12.0 ng/mL, P
= 0.022 and 90.9 ± 33.3 ng/mL versus 45.0 ± 18.0, P
= 0.002, respectively). In addition, PORH in the forearm was significantly negatively associated with SOD activity (r = —0.77, P
= 0.009) as well as the velocity of perfusion increase during TH (r = —0.68, P
= 0.03) and TH% (r = —0.78, P
= 0.008). Our data document the presence of endothelial dysfunction in TCDD-exposed men.
Human & Experimental Toxicology (2007) 26,
705—713 |
| doi_str_mv | 10.1177/0960327107083971 |
| format | Article |
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= 0.022 and 90.9 ± 33.3 ng/mL versus 45.0 ± 18.0, P
= 0.002, respectively). In addition, PORH in the forearm was significantly negatively associated with SOD activity (r = —0.77, P
= 0.009) as well as the velocity of perfusion increase during TH (r = —0.68, P
= 0.03) and TH% (r = —0.78, P
= 0.008). Our data document the presence of endothelial dysfunction in TCDD-exposed men.
Human & Experimental Toxicology (2007) 26,
705—713</description><identifier>ISSN: 0960-3271</identifier><identifier>EISSN: 1477-0903</identifier><identifier>DOI: 10.1177/0960327107083971</identifier><identifier>PMID: 17984141</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Aged ; Biological and medical sciences ; Blood Flow Velocity - drug effects ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - chemically induced ; Cardiovascular Diseases - physiopathology ; Chemical and industrial products toxicology. Toxic occupational diseases ; E-Selectin - blood ; Endothelium, Vascular - drug effects ; Endothelium, Vascular - physiopathology ; Follow-Up Studies ; Forearm - blood supply ; Health risk assessment ; Human exposure ; Humans ; Hyperemia - physiopathology ; Intercellular Adhesion Molecule-1 - blood ; Laser-Doppler Flowmetry ; Lipids - blood ; Male ; Medical sciences ; Men ; Microcirculation - drug effects ; Occupational Diseases - blood ; Occupational Diseases - chemically induced ; Occupational Diseases - physiopathology ; Occupational Exposure ; Occupational hazards ; Pesticides ; Pesticides - blood ; Pesticides - toxicity ; Plasminogen Activator Inhibitor 1 - blood ; Polychlorinated Dibenzodioxins - blood ; Polychlorinated Dibenzodioxins - toxicity ; Regional Blood Flow - drug effects ; Skin - blood supply ; Superoxide Dismutase - blood ; Time Factors ; Toxicity ; Toxicology ; Various organic compounds ; Vein & artery diseases</subject><ispartof>Human & experimental toxicology, 2007-09, Vol.26 (9), p.705-713</ispartof><rights>2008 INIST-CNRS</rights><rights>SAGE Publications © Sep 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-b9fbf54dda73248bd6df1dd877d147e1ff5524be6a05b545c16ace2e04d6da413</citedby><cites>FETCH-LOGICAL-c423t-b9fbf54dda73248bd6df1dd877d147e1ff5524be6a05b545c16ace2e04d6da413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0960327107083971$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0960327107083971$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21945,27830,27901,27902,44921,45309</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/0960327107083971?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19229253$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17984141$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pelclová, Daniela</creatorcontrib><creatorcontrib>Prázný, Martin</creatorcontrib><creatorcontrib>Škrha, Jan</creatorcontrib><creatorcontrib>Fenclová, Zdenka</creatorcontrib><creatorcontrib>Kalousová, Marta</creatorcontrib><creatorcontrib>Urban, Pavel</creatorcontrib><creatorcontrib>Navrátil, Tomáš</creatorcontrib><creatorcontrib>Šenholdová, Zdenka</creatorcontrib><creatorcontrib>Šmerhovský, Zdeněk</creatorcontrib><title>2,3,7,8-TCDD exposure, endothelial dysfunction and impaired microvascular reactivity</title><title>Human & experimental toxicology</title><addtitle>Hum Exp Toxicol</addtitle><description>Vascular function was examined in subjects with long-term high level of serum 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) during their follow-up visits. Their earlier mean peak TCDD level at the time of exposure in 1965—1968 was estimated in the range of 3300—74 000 pg/g lipids. Ten former pesticide production workers heavily exposed to TCDD (age 57 ± 2 years, TCDD about 170 pg/g lipids) were examined in 2001. Extended group of 15 TCDD-exposed men (age 59 ± 3 years, TCDD about 130 pg/g lipids) underwent the same examination in 2004. Findings were compared with a control group of 14 healthy men (age 54 ± 2 years). Skin microvascular reactivity (MVR) was measured by laser Doppler perfusion monitoring in the forearm during post-occlusive reactive hyperemia (PORH) and thermal hyperemia (TH). Several parameters of MVR in men exposed to TCDD were significantly impaired, compared with the control group and further progression of the impairment of MVR has been observed between years 2001 and 2004. Serum concentration of E-selectin and inhibitor of tissue plasminogen activator 1 (PAI-1) was significantly higher in exposed subjects (56.0 ± 18.4 ng/mL versus 40.0 ± 12.0 ng/mL, P
= 0.022 and 90.9 ± 33.3 ng/mL versus 45.0 ± 18.0, P
= 0.002, respectively). In addition, PORH in the forearm was significantly negatively associated with SOD activity (r = —0.77, P
= 0.009) as well as the velocity of perfusion increase during TH (r = —0.68, P
= 0.03) and TH% (r = —0.78, P
= 0.008). Our data document the presence of endothelial dysfunction in TCDD-exposed men.
Human & Experimental Toxicology (2007) 26,
705—713</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blood Flow Velocity - drug effects</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - chemically induced</subject><subject>Cardiovascular Diseases - physiopathology</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>E-Selectin - blood</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Follow-Up Studies</subject><subject>Forearm - blood supply</subject><subject>Health risk assessment</subject><subject>Human exposure</subject><subject>Humans</subject><subject>Hyperemia - physiopathology</subject><subject>Intercellular Adhesion Molecule-1 - blood</subject><subject>Laser-Doppler Flowmetry</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Men</subject><subject>Microcirculation - drug effects</subject><subject>Occupational Diseases - blood</subject><subject>Occupational Diseases - chemically induced</subject><subject>Occupational Diseases - physiopathology</subject><subject>Occupational Exposure</subject><subject>Occupational hazards</subject><subject>Pesticides</subject><subject>Pesticides - blood</subject><subject>Pesticides - toxicity</subject><subject>Plasminogen Activator Inhibitor 1 - blood</subject><subject>Polychlorinated Dibenzodioxins - blood</subject><subject>Polychlorinated Dibenzodioxins - toxicity</subject><subject>Regional Blood Flow - drug effects</subject><subject>Skin - blood supply</subject><subject>Superoxide Dismutase - blood</subject><subject>Time Factors</subject><subject>Toxicity</subject><subject>Toxicology</subject><subject>Various organic compounds</subject><subject>Vein & artery diseases</subject><issn>0960-3271</issn><issn>1477-0903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kM1LwzAYh4Mobk7vnqQIelo1SdOmOcrmFwy8zHNJmzea0S-Tdrj_3pQVBgNP7-F9fu_Hg9A1wQ-EcP6IRYIjygnmOI0EJydoShjnIRY4OkXToR0O_Qm6cG6DMU5ETM7RhHCRMsLIFK3pPJrzeRquF8tlAL9t43oL8wBq1XTfUBpZBmrndF8XnWnqQNYqMFUrjQUVVKawzVa6oi-lDSxIz2xNt7tEZ1qWDq7GOkOfL8_rxVu4-nh9XzytwoLRqAtzoXMdM6UkjyhLc5UoTZRKOVf-CyBaxzFlOSQSx3nM4oIksgAKmHlSMhLN0P1-bmubnx5cl1XGFVCWsoamdxnFLCUJZR68PQI3TW9rf1tGKU69vTTyEN5D_innLOistaaSdpcRnA26s2PdPnIzzu3zCtQhMPr1wN0IeEuy1FbWhXEHTlAqaDzsDveck19wOO7fxX9iUJNS</recordid><startdate>20070901</startdate><enddate>20070901</enddate><creator>Pelclová, Daniela</creator><creator>Prázný, Martin</creator><creator>Škrha, Jan</creator><creator>Fenclová, Zdenka</creator><creator>Kalousová, Marta</creator><creator>Urban, Pavel</creator><creator>Navrátil, Tomáš</creator><creator>Šenholdová, Zdenka</creator><creator>Šmerhovský, Zdeněk</creator><general>SAGE Publications</general><general>Arnold</general><general>Sage Publications Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7ST</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>SOI</scope></search><sort><creationdate>20070901</creationdate><title>2,3,7,8-TCDD exposure, endothelial dysfunction and impaired microvascular reactivity</title><author>Pelclová, Daniela ; Prázný, Martin ; Škrha, Jan ; Fenclová, Zdenka ; Kalousová, Marta ; Urban, Pavel ; Navrátil, Tomáš ; Šenholdová, Zdenka ; Šmerhovský, Zdeněk</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-b9fbf54dda73248bd6df1dd877d147e1ff5524be6a05b545c16ace2e04d6da413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Blood Flow Velocity - drug effects</topic><topic>Cardiovascular Diseases - blood</topic><topic>Cardiovascular Diseases - chemically induced</topic><topic>Cardiovascular Diseases - physiopathology</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>E-Selectin - blood</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Follow-Up Studies</topic><topic>Forearm - blood supply</topic><topic>Health risk assessment</topic><topic>Human exposure</topic><topic>Humans</topic><topic>Hyperemia - physiopathology</topic><topic>Intercellular Adhesion Molecule-1 - blood</topic><topic>Laser-Doppler Flowmetry</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Men</topic><topic>Microcirculation - drug effects</topic><topic>Occupational Diseases - blood</topic><topic>Occupational Diseases - chemically induced</topic><topic>Occupational Diseases - physiopathology</topic><topic>Occupational Exposure</topic><topic>Occupational hazards</topic><topic>Pesticides</topic><topic>Pesticides - blood</topic><topic>Pesticides - toxicity</topic><topic>Plasminogen Activator Inhibitor 1 - blood</topic><topic>Polychlorinated Dibenzodioxins - blood</topic><topic>Polychlorinated Dibenzodioxins - toxicity</topic><topic>Regional Blood Flow - drug effects</topic><topic>Skin - blood supply</topic><topic>Superoxide Dismutase - blood</topic><topic>Time Factors</topic><topic>Toxicity</topic><topic>Toxicology</topic><topic>Various organic compounds</topic><topic>Vein & artery diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pelclová, Daniela</creatorcontrib><creatorcontrib>Prázný, Martin</creatorcontrib><creatorcontrib>Škrha, Jan</creatorcontrib><creatorcontrib>Fenclová, Zdenka</creatorcontrib><creatorcontrib>Kalousová, Marta</creatorcontrib><creatorcontrib>Urban, Pavel</creatorcontrib><creatorcontrib>Navrátil, Tomáš</creatorcontrib><creatorcontrib>Šenholdová, Zdenka</creatorcontrib><creatorcontrib>Šmerhovský, Zdeněk</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Environment Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Environment Abstracts</collection><jtitle>Human & experimental toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Pelclová, Daniela</au><au>Prázný, Martin</au><au>Škrha, Jan</au><au>Fenclová, Zdenka</au><au>Kalousová, Marta</au><au>Urban, Pavel</au><au>Navrátil, Tomáš</au><au>Šenholdová, Zdenka</au><au>Šmerhovský, Zdeněk</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>2,3,7,8-TCDD exposure, endothelial dysfunction and impaired microvascular reactivity</atitle><jtitle>Human & experimental toxicology</jtitle><addtitle>Hum Exp Toxicol</addtitle><date>2007-09-01</date><risdate>2007</risdate><volume>26</volume><issue>9</issue><spage>705</spage><epage>713</epage><pages>705-713</pages><issn>0960-3271</issn><eissn>1477-0903</eissn><abstract>Vascular function was examined in subjects with long-term high level of serum 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) during their follow-up visits. Their earlier mean peak TCDD level at the time of exposure in 1965—1968 was estimated in the range of 3300—74 000 pg/g lipids. Ten former pesticide production workers heavily exposed to TCDD (age 57 ± 2 years, TCDD about 170 pg/g lipids) were examined in 2001. Extended group of 15 TCDD-exposed men (age 59 ± 3 years, TCDD about 130 pg/g lipids) underwent the same examination in 2004. Findings were compared with a control group of 14 healthy men (age 54 ± 2 years). Skin microvascular reactivity (MVR) was measured by laser Doppler perfusion monitoring in the forearm during post-occlusive reactive hyperemia (PORH) and thermal hyperemia (TH). Several parameters of MVR in men exposed to TCDD were significantly impaired, compared with the control group and further progression of the impairment of MVR has been observed between years 2001 and 2004. Serum concentration of E-selectin and inhibitor of tissue plasminogen activator 1 (PAI-1) was significantly higher in exposed subjects (56.0 ± 18.4 ng/mL versus 40.0 ± 12.0 ng/mL, P
= 0.022 and 90.9 ± 33.3 ng/mL versus 45.0 ± 18.0, P
= 0.002, respectively). In addition, PORH in the forearm was significantly negatively associated with SOD activity (r = —0.77, P
= 0.009) as well as the velocity of perfusion increase during TH (r = —0.68, P
= 0.03) and TH% (r = —0.78, P
= 0.008). Our data document the presence of endothelial dysfunction in TCDD-exposed men.
Human & Experimental Toxicology (2007) 26,
705—713</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>17984141</pmid><doi>10.1177/0960327107083971</doi><tpages>9</tpages></addata></record> |
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| ispartof | Human & experimental toxicology, 2007-09, Vol.26 (9), p.705-713 |
| issn | 0960-3271 1477-0903 |
| language | eng |
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| source | Sage Journals GOLD Open Access 2024 |
| subjects | Aged Biological and medical sciences Blood Flow Velocity - drug effects Cardiovascular Diseases - blood Cardiovascular Diseases - chemically induced Cardiovascular Diseases - physiopathology Chemical and industrial products toxicology. Toxic occupational diseases E-Selectin - blood Endothelium, Vascular - drug effects Endothelium, Vascular - physiopathology Follow-Up Studies Forearm - blood supply Health risk assessment Human exposure Humans Hyperemia - physiopathology Intercellular Adhesion Molecule-1 - blood Laser-Doppler Flowmetry Lipids - blood Male Medical sciences Men Microcirculation - drug effects Occupational Diseases - blood Occupational Diseases - chemically induced Occupational Diseases - physiopathology Occupational Exposure Occupational hazards Pesticides Pesticides - blood Pesticides - toxicity Plasminogen Activator Inhibitor 1 - blood Polychlorinated Dibenzodioxins - blood Polychlorinated Dibenzodioxins - toxicity Regional Blood Flow - drug effects Skin - blood supply Superoxide Dismutase - blood Time Factors Toxicity Toxicology Various organic compounds Vein & artery diseases |
| title | 2,3,7,8-TCDD exposure, endothelial dysfunction and impaired microvascular reactivity |
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