Development and validation of rapid and sensitive LC methods with PDA and fluorescence detection for determination of piribedil in rat plasma and brain tissues and their pharmacokinetic application

Simple, selective and sensitive high‐performance liquid chromatographic (HPLC) bioanalytical methods using fluorescence (FL) and photodiode array (PDA) detectors were developed and validated for determination of piribedil (PBD), an anti‐Parkinson's drug, in rat plasma and brain samples, with te...

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Veröffentlicht in:	Biomedical chromatography 2018-10, Vol.32 (10), p.e4303-n/a
Hauptverfasser:	Uppuluri, Chandra Teja, Dalvi, Avantika V., Bommireddy, Ekta Prasanthi, Ravi, Punna Rao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - metabolism Brain Chemistry brain distribution Chromatography, High Pressure Liquid - methods Drug Stability fluorescence HPLC bioanalytical method Limit of Detection Linear Models photodiode array piribedil Piribedil - analysis Piribedil - chemistry Piribedil - isolation & purification Piribedil - pharmacokinetics rat pharmacokinetics Rats Reproducibility of Results Spectrometry, Fluorescence - methods
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