Struggles for equivalence: In vitro developmental toxicity model evolution in pharmaceuticals in 2006

Our group has been using the ECVAM Embryonic Stem Cell assay to predict developmental toxicity. In order to improve the separation of non-teratogens from weak teratogens, we have employed measures of gene expression, and different statistical methods from those originally used to develop the test. T...

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Veröffentlicht in:	Toxicology in vitro 2007-12, Vol.21 (8), p.1545-1551
Hauptverfasser:	Chapin, Robert, Stedman, Donald, Paquette, Jennifer, Streck, Randal, Kumpf, Steven, Deng, Shibing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Testing Alternatives Animals Cell Differentiation Development toxicity Drug Industry Embryonic stem cell test Gene Expression Regulation In vitro assay Mice Models, Biological Stem Cells - cytology Stem Cells - drug effects Teratogens - toxicity Toxicity Tests - methods
Online-Zugang:	Volltext
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