The Main Sources of Intersubject Variability in Neuronal Activation for Reading Aloud
The aim of this study was to find the most prominent source of intersubject variability in neuronal activation for reading familiar words aloud. To this end, we collected functional imaging data from a large sample of subjects ( = 76) with different demographic characteristics such as handedness, se...
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| Veröffentlicht in: | Journal of cognitive neuroscience 2009-04, Vol.21 (4), p.654-668 |
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| creator | Kherif, Ferath Josse, Goulven Seghier, Mohamed L. Price, Cathy J. |
| description | The aim of this study was to find the most prominent source of intersubject variability in neuronal activation for reading familiar words aloud. To this end, we collected functional imaging data from a large sample of subjects (
= 76) with different demographic characteristics such as handedness, sex, and age, while reading. The subject-by-subject error variance was estimated from a one-sample
test (on all 76 subjects) and was reduced to a lower dimension using principal components decomposition. A Gaussian Mixture Model was then applied to dissociate different subgroups of subjects that explained the main sources of variability in the data. This resulted in the identification of four different subject groups. The comparison of these subgroups to the subjects' demographic details showed that age had a significant effect on the subject partitioning. In addition, a region-by-group dissociation in the dorsal and the ventral inferior frontal cortex was consistent with previously reported dissociations in semantic and nonsemantic reading strategies. In contrast to these significant findings, the groupings did not differentiate subjects on the basis of either sex or handedness, nor did they segregate the subjects with right- versus left-lateralized reading activation. We therefore conclude that, of the variables tested, age and reading strategy were the most prominent source of variability in activation for reading familiar words aloud. |
| doi_str_mv | 10.1162/jocn.2009.21084 |
| format | Article |
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= 76) with different demographic characteristics such as handedness, sex, and age, while reading. The subject-by-subject error variance was estimated from a one-sample
test (on all 76 subjects) and was reduced to a lower dimension using principal components decomposition. A Gaussian Mixture Model was then applied to dissociate different subgroups of subjects that explained the main sources of variability in the data. This resulted in the identification of four different subject groups. The comparison of these subgroups to the subjects' demographic details showed that age had a significant effect on the subject partitioning. In addition, a region-by-group dissociation in the dorsal and the ventral inferior frontal cortex was consistent with previously reported dissociations in semantic and nonsemantic reading strategies. In contrast to these significant findings, the groupings did not differentiate subjects on the basis of either sex or handedness, nor did they segregate the subjects with right- versus left-lateralized reading activation. We therefore conclude that, of the variables tested, age and reading strategy were the most prominent source of variability in activation for reading familiar words aloud.</description><identifier>ISSN: 0898-929X</identifier><identifier>EISSN: 1530-8898</identifier><identifier>DOI: 10.1162/jocn.2009.21084</identifier><identifier>PMID: 18702580</identifier><identifier>CODEN: JCONEO</identifier><language>eng</language><publisher>One Rogers Street, Cambridge, MA 02142-1209, USA: MIT Press</publisher><subject>Adolescent ; Adult ; Age Differences ; Age Factors ; Analysis of Variance ; Brain ; Brain - blood supply ; Brain - physiology ; Brain Hemisphere Functions ; Brain Mapping ; Child ; Diagnostic Tests ; Error of Measurement ; Error Patterns ; Female ; Functional Laterality - physiology ; Gender Differences ; Handedness ; Humans ; Image Processing, Computer-Assisted - methods ; Individual Differences ; Lateral Dominance ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Neurons ; Neurosciences ; Normal Distribution ; Nurse patient relationships ; Oral Reading ; Oxygen - blood ; Phonetics ; Principal Component Analysis ; Reaction Time - physiology ; Reading ; Reading Strategies ; Semantics ; Statistical Analysis ; Studies ; Young Adult</subject><ispartof>Journal of cognitive neuroscience, 2009-04, Vol.21 (4), p.654-668</ispartof><rights>Copyright MIT Press Journals Apr 2009</rights><rights>2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c597t-6df4d7572ed206f2744a9c5042a3302ff3323b3429e29f25042d9e1351201cd53</citedby><cites>FETCH-LOGICAL-c597t-6df4d7572ed206f2744a9c5042a3302ff3323b3429e29f25042d9e1351201cd53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://direct.mit.edu/jocn/article/doi/10.1162/jocn.2009.21084$$EHTML$$P50$$Gmit$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,53984,53985</link.rule.ids><backlink>$$Uhttp://eric.ed.gov/ERICWebPortal/detail?accno=EJ864056$$DView record in ERIC$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18702580$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kherif, Ferath</creatorcontrib><creatorcontrib>Josse, Goulven</creatorcontrib><creatorcontrib>Seghier, Mohamed L.</creatorcontrib><creatorcontrib>Price, Cathy J.</creatorcontrib><title>The Main Sources of Intersubject Variability in Neuronal Activation for Reading Aloud</title><title>Journal of cognitive neuroscience</title><addtitle>J Cogn Neurosci</addtitle><description>The aim of this study was to find the most prominent source of intersubject variability in neuronal activation for reading familiar words aloud. To this end, we collected functional imaging data from a large sample of subjects (
= 76) with different demographic characteristics such as handedness, sex, and age, while reading. The subject-by-subject error variance was estimated from a one-sample
test (on all 76 subjects) and was reduced to a lower dimension using principal components decomposition. A Gaussian Mixture Model was then applied to dissociate different subgroups of subjects that explained the main sources of variability in the data. This resulted in the identification of four different subject groups. The comparison of these subgroups to the subjects' demographic details showed that age had a significant effect on the subject partitioning. In addition, a region-by-group dissociation in the dorsal and the ventral inferior frontal cortex was consistent with previously reported dissociations in semantic and nonsemantic reading strategies. In contrast to these significant findings, the groupings did not differentiate subjects on the basis of either sex or handedness, nor did they segregate the subjects with right- versus left-lateralized reading activation. We therefore conclude that, of the variables tested, age and reading strategy were the most prominent source of variability in activation for reading familiar words aloud.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Differences</subject><subject>Age Factors</subject><subject>Analysis of Variance</subject><subject>Brain</subject><subject>Brain - blood supply</subject><subject>Brain - physiology</subject><subject>Brain Hemisphere Functions</subject><subject>Brain Mapping</subject><subject>Child</subject><subject>Diagnostic Tests</subject><subject>Error of Measurement</subject><subject>Error Patterns</subject><subject>Female</subject><subject>Functional Laterality - physiology</subject><subject>Gender Differences</subject><subject>Handedness</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted - methods</subject><subject>Individual Differences</subject><subject>Lateral Dominance</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neurons</subject><subject>Neurosciences</subject><subject>Normal Distribution</subject><subject>Nurse patient relationships</subject><subject>Oral Reading</subject><subject>Oxygen - blood</subject><subject>Phonetics</subject><subject>Principal Component Analysis</subject><subject>Reaction Time - physiology</subject><subject>Reading</subject><subject>Reading Strategies</subject><subject>Semantics</subject><subject>Statistical Analysis</subject><subject>Studies</subject><subject>Young Adult</subject><issn>0898-929X</issn><issn>1530-8898</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks1vEzEQxS0EoqFw5oKQxYEL2nQ8_ljvpVIUFSgqIEGLuFmO19s62qyDdzdS-etxSFQKKuppLL2fx88zj5DnDKaMKTxaRtdNEaCaIgMtHpAJkxwKrSv9kEwgl6LC6vsBedL3SwBAqcRjcsB0mY8aJuTi_MrTjzZ09Gsck_M9jQ097Qaf-nGx9G6g32wKdhHaMFzTjH3yY4qdbenMDWFjhxA72sREv3hbh-6Szto41k_Jo8a2vX-2r4fk4u3J-fx9cfb53el8dlY4WZVDoepG1KUs0dcIqsFSCFs5CQIt54BNwznyBRdYeawa3Ap15RmXDIG5WvJDcrzrux4XK1873w3JtmadwsqmaxNtMH8rXbgyl3FjsFRKc54bvN43SPHH6PvBrELvfNvazsexN1oqLUu4H1QlCCWVvBdEEKVQqDP46h9wmTeQJ5sZ5KCQI2ToaAe5FPs--ebmbwzMNgFmmwCzTYD5nYB84-Xtkfzh9yvPwIsd4FNwN_LJB60ESJXl-U5ehVuOtq9skAVh8l5QqPwismzAgDY_w_oOF2_u6PI_z78AmgLXwA</recordid><startdate>20090401</startdate><enddate>20090401</enddate><creator>Kherif, Ferath</creator><creator>Josse, Goulven</creator><creator>Seghier, Mohamed L.</creator><creator>Price, Cathy J.</creator><general>MIT Press</general><general>MIT Press Journals, The</general><scope>7SW</scope><scope>BJH</scope><scope>BNH</scope><scope>BNI</scope><scope>BNJ</scope><scope>BNO</scope><scope>ERI</scope><scope>PET</scope><scope>REK</scope><scope>WWN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>7T9</scope><scope>5PM</scope></search><sort><creationdate>20090401</creationdate><title>The Main Sources of Intersubject Variability in Neuronal Activation for Reading Aloud</title><author>Kherif, Ferath ; 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To this end, we collected functional imaging data from a large sample of subjects (
= 76) with different demographic characteristics such as handedness, sex, and age, while reading. The subject-by-subject error variance was estimated from a one-sample
test (on all 76 subjects) and was reduced to a lower dimension using principal components decomposition. A Gaussian Mixture Model was then applied to dissociate different subgroups of subjects that explained the main sources of variability in the data. This resulted in the identification of four different subject groups. The comparison of these subgroups to the subjects' demographic details showed that age had a significant effect on the subject partitioning. In addition, a region-by-group dissociation in the dorsal and the ventral inferior frontal cortex was consistent with previously reported dissociations in semantic and nonsemantic reading strategies. In contrast to these significant findings, the groupings did not differentiate subjects on the basis of either sex or handedness, nor did they segregate the subjects with right- versus left-lateralized reading activation. We therefore conclude that, of the variables tested, age and reading strategy were the most prominent source of variability in activation for reading familiar words aloud.</abstract><cop>One Rogers Street, Cambridge, MA 02142-1209, USA</cop><pub>MIT Press</pub><pmid>18702580</pmid><doi>10.1162/jocn.2009.21084</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of cognitive neuroscience, 2009-04, Vol.21 (4), p.654-668 |
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| subjects | Adolescent Adult Age Differences Age Factors Analysis of Variance Brain Brain - blood supply Brain - physiology Brain Hemisphere Functions Brain Mapping Child Diagnostic Tests Error of Measurement Error Patterns Female Functional Laterality - physiology Gender Differences Handedness Humans Image Processing, Computer-Assisted - methods Individual Differences Lateral Dominance Magnetic Resonance Imaging - methods Male Middle Aged Neurons Neurosciences Normal Distribution Nurse patient relationships Oral Reading Oxygen - blood Phonetics Principal Component Analysis Reaction Time - physiology Reading Reading Strategies Semantics Statistical Analysis Studies Young Adult |
| title | The Main Sources of Intersubject Variability in Neuronal Activation for Reading Aloud |
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