The time course of brief and prolonged topical 8% capsaicin-induced desensitization in healthy volunteers evaluated by quantitative sensory testing and vasomotor imaging
Topically applied high-concentration capsaicin induces reversible dermo-epidermal denervation and depletion of capsaicin-sensitive nociceptors. This causes desensitization of distinct sensory modalities and is used to treat peripheral neuropathic pain and itch. For high-concentration capsaicin, the...
Gespeichert in:
| Veröffentlicht in: | Experimental brain research 2018-08, Vol.236 (8), p.2231-2244 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2244 |
|---|---|
| container_issue | 8 |
| container_start_page | 2231 |
| container_title | Experimental brain research |
| container_volume | 236 |
| creator | Lo Vecchio, Silvia Andersen, Hjalte Holm Arendt-Nielsen, Lars |
| description | Topically applied high-concentration capsaicin induces reversible dermo-epidermal denervation and depletion of capsaicin-sensitive nociceptors. This causes desensitization of distinct sensory modalities and is used to treat peripheral neuropathic pain and itch. For high-concentration capsaicin, the selectivity of loss of function and functional recovery rates of various afferent fibers subpopulations are unknown. This study used comprehensive quantitative sensory testing and vasomotor imaging to assess effectiveness, duration and sensory selectivity of high-concentration 8% capsaicin–ablation. Skin areas in 14 healthy volunteers were randomized to treatment with 8% capsaicin/vehicle patches for 1 and 24 h and underwent comprehensive sensory and vasomotor testing at 1, 7 and 21 days postpatch removal. Tests consisted of thermal detection and pain thresholds, tactile and vibration detection thresholds, mechanical pain threshold and mechanical pain sensitivity as well as micro-vascular and itch reactivity to histamine provocations. The 24 h capsaicin drastically inhibited warmth detection (
P
|
| doi_str_mv | 10.1007/s00221-018-5299-y |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2047289943</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A546322325</galeid><sourcerecordid>A546322325</sourcerecordid><originalsourceid>FETCH-LOGICAL-c530t-92f26b58653b08c7b729630de23d8c46d96879677a9e6606af3092879ec1efa53</originalsourceid><addsrcrecordid>eNp1ks9u1DAQxiMEokvhAbggS4gKDin-kzjxsaoKVKqEBOVsOc4k6yqxt7azIrwRb4lDCmURyAfL4983Y898Wfac4FOCcfU2YEwpyTGp85IKkc8Psg0pGM0JwfxhtsGYFHlRE3GUPQnhZjmyCj_Ojqioi7IoxCb7fr0FFM0ISLvJB0CuQ4030CFlW7TzbnC2hxZFtzNaDah-hbTaBWW0sbmx7aTTZQsBbDDRfFPROIuMRVtQQ9zOaO-GyUYAHxDs1TCpmPhmRreTstHExO8BLWrnZxQhRGP7n6X3KrjRReeRGVWfok-zR50aAjy724-zL-8urs8_5Fcf31-en13lumQ45oJ2lDdlzUvW4FpXTUUFZ7gFytpaF7wVvK4EryolgHPMVcewoCkEmkCnSnacvV7zps_fTulFcjRBwzAoC24KkuKiorUQBUvoy7_Qm9REm163UJyVombFPdWrAaSxnYte6SWpPCsTRSmjS9nTf1BptTAa7Sx0JsUPBG8OBImJ8DX2agpBXn7-dMie_MGuswlpMsu0wiFIVlB7F4KHTu586r-fJcFy8ZxcPSeT5-TiOTknzYu7LkzNCO1vxS-TJYCuQEhXyU3-vk3_z_oD3Pfhug</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2046359834</pqid></control><display><type>article</type><title>The time course of brief and prolonged topical 8% capsaicin-induced desensitization in healthy volunteers evaluated by quantitative sensory testing and vasomotor imaging</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Lo Vecchio, Silvia ; Andersen, Hjalte Holm ; Arendt-Nielsen, Lars</creator><creatorcontrib>Lo Vecchio, Silvia ; Andersen, Hjalte Holm ; Arendt-Nielsen, Lars</creatorcontrib><description>Topically applied high-concentration capsaicin induces reversible dermo-epidermal denervation and depletion of capsaicin-sensitive nociceptors. This causes desensitization of distinct sensory modalities and is used to treat peripheral neuropathic pain and itch. For high-concentration capsaicin, the selectivity of loss of function and functional recovery rates of various afferent fibers subpopulations are unknown. This study used comprehensive quantitative sensory testing and vasomotor imaging to assess effectiveness, duration and sensory selectivity of high-concentration 8% capsaicin–ablation. Skin areas in 14 healthy volunteers were randomized to treatment with 8% capsaicin/vehicle patches for 1 and 24 h and underwent comprehensive sensory and vasomotor testing at 1, 7 and 21 days postpatch removal. Tests consisted of thermal detection and pain thresholds, tactile and vibration detection thresholds, mechanical pain threshold and mechanical pain sensitivity as well as micro-vascular and itch reactivity to histamine provocations. The 24 h capsaicin drastically inhibited warmth detection (
P
< 0.001), heat pain (
P
< 0.001) as well as histamine-induced itch (
P
< 0.05) and neurogenic flare (
P
< 0.001), but had no impact on tactile sensitivity, cold detection and cold pain. A marginal decrease in mechanical pain sensitivity was observed (
P
< 0.05). Capsaicin for 1 h had limited and transient sensory effects only affecting warmth and heat sensations. Time-dependent functional recovery was almost complete 21 days after the 24 h capsaicin exposure, while recovery of neurogenic inflammatory responsiveness remained partial. The psychophysically assessed sensory deficiencies induced by the used 8% capsaicin–ablation correspond well with a predominant effect on TRPV1
+
–cutaneous fibers. The method is easy to apply, well tolerated, and utilizable for studies on, e.g., interactions between skin barrier, inflammation and capsaicin-sensitive afferents.</description><identifier>ISSN: 0014-4819</identifier><identifier>EISSN: 1432-1106</identifier><identifier>DOI: 10.1007/s00221-018-5299-y</identifier><identifier>PMID: 29845449</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescent ; Adult ; Biomedical and Life Sciences ; Biomedicine ; Capsaicin ; Capsaicin - administration & dosage ; Capsaicin - pharmacology ; Capsaicin receptors ; Care and treatment ; Denervation ; Desensitization (Psychology) ; Dosage and administration ; Dose-response relationship ; Fibers ; Habituation (Psychophysiology) ; Health aspects ; Histamine ; Histamine - pharmacology ; Histamine Agonists - pharmacology ; Humans ; Inflammation ; Male ; Nerve Fibers, Unmyelinated - drug effects ; Neurology ; Neurosciences ; Nociception - drug effects ; Nociceptors ; Nociceptors - drug effects ; Pain ; Pain perception ; Pain Threshold - drug effects ; Perfusion Imaging ; Peripheral neuropathy ; Pruritus - chemically induced ; Pruritus - drug therapy ; Recovery of function ; Research Article ; Sensory neurons ; Sensory System Agents - administration & dosage ; Sensory System Agents - pharmacology ; Skin ; Skin - diagnostic imaging ; Skin - drug effects ; Skin - physiopathology ; Subpopulations ; Thermosensing - drug effects ; Time Factors ; Touch Perception - drug effects ; Young Adult</subject><ispartof>Experimental brain research, 2018-08, Vol.236 (8), p.2231-2244</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2018</rights><rights>COPYRIGHT 2018 Springer</rights><rights>Experimental Brain Research is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c530t-92f26b58653b08c7b729630de23d8c46d96879677a9e6606af3092879ec1efa53</citedby><cites>FETCH-LOGICAL-c530t-92f26b58653b08c7b729630de23d8c46d96879677a9e6606af3092879ec1efa53</cites><orcidid>0000-0002-7596-7764</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00221-018-5299-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00221-018-5299-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29845449$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lo Vecchio, Silvia</creatorcontrib><creatorcontrib>Andersen, Hjalte Holm</creatorcontrib><creatorcontrib>Arendt-Nielsen, Lars</creatorcontrib><title>The time course of brief and prolonged topical 8% capsaicin-induced desensitization in healthy volunteers evaluated by quantitative sensory testing and vasomotor imaging</title><title>Experimental brain research</title><addtitle>Exp Brain Res</addtitle><addtitle>Exp Brain Res</addtitle><description>Topically applied high-concentration capsaicin induces reversible dermo-epidermal denervation and depletion of capsaicin-sensitive nociceptors. This causes desensitization of distinct sensory modalities and is used to treat peripheral neuropathic pain and itch. For high-concentration capsaicin, the selectivity of loss of function and functional recovery rates of various afferent fibers subpopulations are unknown. This study used comprehensive quantitative sensory testing and vasomotor imaging to assess effectiveness, duration and sensory selectivity of high-concentration 8% capsaicin–ablation. Skin areas in 14 healthy volunteers were randomized to treatment with 8% capsaicin/vehicle patches for 1 and 24 h and underwent comprehensive sensory and vasomotor testing at 1, 7 and 21 days postpatch removal. Tests consisted of thermal detection and pain thresholds, tactile and vibration detection thresholds, mechanical pain threshold and mechanical pain sensitivity as well as micro-vascular and itch reactivity to histamine provocations. The 24 h capsaicin drastically inhibited warmth detection (
P
< 0.001), heat pain (
P
< 0.001) as well as histamine-induced itch (
P
< 0.05) and neurogenic flare (
P
< 0.001), but had no impact on tactile sensitivity, cold detection and cold pain. A marginal decrease in mechanical pain sensitivity was observed (
P
< 0.05). Capsaicin for 1 h had limited and transient sensory effects only affecting warmth and heat sensations. Time-dependent functional recovery was almost complete 21 days after the 24 h capsaicin exposure, while recovery of neurogenic inflammatory responsiveness remained partial. The psychophysically assessed sensory deficiencies induced by the used 8% capsaicin–ablation correspond well with a predominant effect on TRPV1
+
–cutaneous fibers. The method is easy to apply, well tolerated, and utilizable for studies on, e.g., interactions between skin barrier, inflammation and capsaicin-sensitive afferents.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Capsaicin</subject><subject>Capsaicin - administration & dosage</subject><subject>Capsaicin - pharmacology</subject><subject>Capsaicin receptors</subject><subject>Care and treatment</subject><subject>Denervation</subject><subject>Desensitization (Psychology)</subject><subject>Dosage and administration</subject><subject>Dose-response relationship</subject><subject>Fibers</subject><subject>Habituation (Psychophysiology)</subject><subject>Health aspects</subject><subject>Histamine</subject><subject>Histamine - pharmacology</subject><subject>Histamine Agonists - pharmacology</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Male</subject><subject>Nerve Fibers, Unmyelinated - drug effects</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Nociception - drug effects</subject><subject>Nociceptors</subject><subject>Nociceptors - drug effects</subject><subject>Pain</subject><subject>Pain perception</subject><subject>Pain Threshold - drug effects</subject><subject>Perfusion Imaging</subject><subject>Peripheral neuropathy</subject><subject>Pruritus - chemically induced</subject><subject>Pruritus - drug therapy</subject><subject>Recovery of function</subject><subject>Research Article</subject><subject>Sensory neurons</subject><subject>Sensory System Agents - administration & dosage</subject><subject>Sensory System Agents - pharmacology</subject><subject>Skin</subject><subject>Skin - diagnostic imaging</subject><subject>Skin - drug effects</subject><subject>Skin - physiopathology</subject><subject>Subpopulations</subject><subject>Thermosensing - drug effects</subject><subject>Time Factors</subject><subject>Touch Perception - drug effects</subject><subject>Young Adult</subject><issn>0014-4819</issn><issn>1432-1106</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1ks9u1DAQxiMEokvhAbggS4gKDin-kzjxsaoKVKqEBOVsOc4k6yqxt7azIrwRb4lDCmURyAfL4983Y898Wfac4FOCcfU2YEwpyTGp85IKkc8Psg0pGM0JwfxhtsGYFHlRE3GUPQnhZjmyCj_Ojqioi7IoxCb7fr0FFM0ISLvJB0CuQ4030CFlW7TzbnC2hxZFtzNaDah-hbTaBWW0sbmx7aTTZQsBbDDRfFPROIuMRVtQQ9zOaO-GyUYAHxDs1TCpmPhmRreTstHExO8BLWrnZxQhRGP7n6X3KrjRReeRGVWfok-zR50aAjy724-zL-8urs8_5Fcf31-en13lumQ45oJ2lDdlzUvW4FpXTUUFZ7gFytpaF7wVvK4EryolgHPMVcewoCkEmkCnSnacvV7zps_fTulFcjRBwzAoC24KkuKiorUQBUvoy7_Qm9REm163UJyVombFPdWrAaSxnYte6SWpPCsTRSmjS9nTf1BptTAa7Sx0JsUPBG8OBImJ8DX2agpBXn7-dMie_MGuswlpMsu0wiFIVlB7F4KHTu586r-fJcFy8ZxcPSeT5-TiOTknzYu7LkzNCO1vxS-TJYCuQEhXyU3-vk3_z_oD3Pfhug</recordid><startdate>20180801</startdate><enddate>20180801</enddate><creator>Lo Vecchio, Silvia</creator><creator>Andersen, Hjalte Holm</creator><creator>Arendt-Nielsen, Lars</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>0-V</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88J</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2R</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7596-7764</orcidid></search><sort><creationdate>20180801</creationdate><title>The time course of brief and prolonged topical 8% capsaicin-induced desensitization in healthy volunteers evaluated by quantitative sensory testing and vasomotor imaging</title><author>Lo Vecchio, Silvia ; Andersen, Hjalte Holm ; Arendt-Nielsen, Lars</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c530t-92f26b58653b08c7b729630de23d8c46d96879677a9e6606af3092879ec1efa53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Capsaicin</topic><topic>Capsaicin - administration & dosage</topic><topic>Capsaicin - pharmacology</topic><topic>Capsaicin receptors</topic><topic>Care and treatment</topic><topic>Denervation</topic><topic>Desensitization (Psychology)</topic><topic>Dosage and administration</topic><topic>Dose-response relationship</topic><topic>Fibers</topic><topic>Habituation (Psychophysiology)</topic><topic>Health aspects</topic><topic>Histamine</topic><topic>Histamine - pharmacology</topic><topic>Histamine Agonists - pharmacology</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Male</topic><topic>Nerve Fibers, Unmyelinated - drug effects</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Nociception - drug effects</topic><topic>Nociceptors</topic><topic>Nociceptors - drug effects</topic><topic>Pain</topic><topic>Pain perception</topic><topic>Pain Threshold - drug effects</topic><topic>Perfusion Imaging</topic><topic>Peripheral neuropathy</topic><topic>Pruritus - chemically induced</topic><topic>Pruritus - drug therapy</topic><topic>Recovery of function</topic><topic>Research Article</topic><topic>Sensory neurons</topic><topic>Sensory System Agents - administration & dosage</topic><topic>Sensory System Agents - pharmacology</topic><topic>Skin</topic><topic>Skin - diagnostic imaging</topic><topic>Skin - drug effects</topic><topic>Skin - physiopathology</topic><topic>Subpopulations</topic><topic>Thermosensing - drug effects</topic><topic>Time Factors</topic><topic>Touch Perception - drug effects</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lo Vecchio, Silvia</creatorcontrib><creatorcontrib>Andersen, Hjalte Holm</creatorcontrib><creatorcontrib>Arendt-Nielsen, Lars</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Social Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lo Vecchio, Silvia</au><au>Andersen, Hjalte Holm</au><au>Arendt-Nielsen, Lars</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The time course of brief and prolonged topical 8% capsaicin-induced desensitization in healthy volunteers evaluated by quantitative sensory testing and vasomotor imaging</atitle><jtitle>Experimental brain research</jtitle><stitle>Exp Brain Res</stitle><addtitle>Exp Brain Res</addtitle><date>2018-08-01</date><risdate>2018</risdate><volume>236</volume><issue>8</issue><spage>2231</spage><epage>2244</epage><pages>2231-2244</pages><issn>0014-4819</issn><eissn>1432-1106</eissn><abstract>Topically applied high-concentration capsaicin induces reversible dermo-epidermal denervation and depletion of capsaicin-sensitive nociceptors. This causes desensitization of distinct sensory modalities and is used to treat peripheral neuropathic pain and itch. For high-concentration capsaicin, the selectivity of loss of function and functional recovery rates of various afferent fibers subpopulations are unknown. This study used comprehensive quantitative sensory testing and vasomotor imaging to assess effectiveness, duration and sensory selectivity of high-concentration 8% capsaicin–ablation. Skin areas in 14 healthy volunteers were randomized to treatment with 8% capsaicin/vehicle patches for 1 and 24 h and underwent comprehensive sensory and vasomotor testing at 1, 7 and 21 days postpatch removal. Tests consisted of thermal detection and pain thresholds, tactile and vibration detection thresholds, mechanical pain threshold and mechanical pain sensitivity as well as micro-vascular and itch reactivity to histamine provocations. The 24 h capsaicin drastically inhibited warmth detection (
P
< 0.001), heat pain (
P
< 0.001) as well as histamine-induced itch (
P
< 0.05) and neurogenic flare (
P
< 0.001), but had no impact on tactile sensitivity, cold detection and cold pain. A marginal decrease in mechanical pain sensitivity was observed (
P
< 0.05). Capsaicin for 1 h had limited and transient sensory effects only affecting warmth and heat sensations. Time-dependent functional recovery was almost complete 21 days after the 24 h capsaicin exposure, while recovery of neurogenic inflammatory responsiveness remained partial. The psychophysically assessed sensory deficiencies induced by the used 8% capsaicin–ablation correspond well with a predominant effect on TRPV1
+
–cutaneous fibers. The method is easy to apply, well tolerated, and utilizable for studies on, e.g., interactions between skin barrier, inflammation and capsaicin-sensitive afferents.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>29845449</pmid><doi>10.1007/s00221-018-5299-y</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-7596-7764</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-4819 |
| ispartof | Experimental brain research, 2018-08, Vol.236 (8), p.2231-2244 |
| issn | 0014-4819 1432-1106 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2047289943 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adolescent Adult Biomedical and Life Sciences Biomedicine Capsaicin Capsaicin - administration & dosage Capsaicin - pharmacology Capsaicin receptors Care and treatment Denervation Desensitization (Psychology) Dosage and administration Dose-response relationship Fibers Habituation (Psychophysiology) Health aspects Histamine Histamine - pharmacology Histamine Agonists - pharmacology Humans Inflammation Male Nerve Fibers, Unmyelinated - drug effects Neurology Neurosciences Nociception - drug effects Nociceptors Nociceptors - drug effects Pain Pain perception Pain Threshold - drug effects Perfusion Imaging Peripheral neuropathy Pruritus - chemically induced Pruritus - drug therapy Recovery of function Research Article Sensory neurons Sensory System Agents - administration & dosage Sensory System Agents - pharmacology Skin Skin - diagnostic imaging Skin - drug effects Skin - physiopathology Subpopulations Thermosensing - drug effects Time Factors Touch Perception - drug effects Young Adult |
| title | The time course of brief and prolonged topical 8% capsaicin-induced desensitization in healthy volunteers evaluated by quantitative sensory testing and vasomotor imaging |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T06%3A05%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20time%20course%20of%20brief%20and%20prolonged%20topical%208%25%20capsaicin-induced%20desensitization%20in%20healthy%20volunteers%20evaluated%20by%20quantitative%20sensory%20testing%20and%20vasomotor%20imaging&rft.jtitle=Experimental%20brain%20research&rft.au=Lo%20Vecchio,%20Silvia&rft.date=2018-08-01&rft.volume=236&rft.issue=8&rft.spage=2231&rft.epage=2244&rft.pages=2231-2244&rft.issn=0014-4819&rft.eissn=1432-1106&rft_id=info:doi/10.1007/s00221-018-5299-y&rft_dat=%3Cgale_proqu%3EA546322325%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2046359834&rft_id=info:pmid/29845449&rft_galeid=A546322325&rfr_iscdi=true |