Exposure to a context previously associated with nausea elicits conditioned gaping in rats: A model of anticipatory nausea
Following one or more chemotherapy treatments, many patients report that they experience anticipatory nausea. This phase of nausea has been interpreted as a classically conditioned response where a conditional association develops between the contextual clinic cues and the nausea and/or vomiting tha...
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| Veröffentlicht in: | Behavioural brain research 2008-02, Vol.187 (1), p.33-40 |
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| creator | Limebeer, Cheryl L. Krohn, Jon P. Cross-Mellor, Shelley Litt, Devin E. Ossenkopp, Klaus-Peter Parker, Linda A. |
| description | Following one or more chemotherapy treatments, many patients report that they experience anticipatory nausea. This phase of nausea has been interpreted as a classically conditioned response where a conditional association develops between the contextual clinic cues and the nausea and/or vomiting that developed following treatment. Although rats do not vomit, they display a distinctive gaping reaction when exposed a flavored solution previously paired with a toxin. Here we report that, even in the absence of a flavored solution, rats display conditioned gaping reactions during exposure to a distinctive context previously paired with a high dose of lithium (Experiment 1 with a distinctive odor and Experiment 3 without a distinctive odor), a low dose of lithium (Experiment 2) or provocative vestibular stimulation (Experiment 2). These results suggest that the conditioned gaping reaction in rats is selectively elicited by nausea-paired contextual stimuli, as well as flavors. This rat model of anticipatory nausea may serve as a valuable preclinical tool to evaluate the effectiveness of anti-nausea treatments and the side effect of nausea produced by newly developed pharmaceutical compounds intended for other clinical treatments. |
| doi_str_mv | 10.1016/j.bbr.2007.08.024 |
| format | Article |
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This phase of nausea has been interpreted as a classically conditioned response where a conditional association develops between the contextual clinic cues and the nausea and/or vomiting that developed following treatment. Although rats do not vomit, they display a distinctive gaping reaction when exposed a flavored solution previously paired with a toxin. Here we report that, even in the absence of a flavored solution, rats display conditioned gaping reactions during exposure to a distinctive context previously paired with a high dose of lithium (Experiment 1 with a distinctive odor and Experiment 3 without a distinctive odor), a low dose of lithium (Experiment 2) or provocative vestibular stimulation (Experiment 2). These results suggest that the conditioned gaping reaction in rats is selectively elicited by nausea-paired contextual stimuli, as well as flavors. This rat model of anticipatory nausea may serve as a valuable preclinical tool to evaluate the effectiveness of anti-nausea treatments and the side effect of nausea produced by newly developed pharmaceutical compounds intended for other clinical treatments.</description><identifier>ISSN: 0166-4328</identifier><identifier>EISSN: 1872-7549</identifier><identifier>DOI: 10.1016/j.bbr.2007.08.024</identifier><identifier>PMID: 17897732</identifier><identifier>CODEN: BBREDI</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Animals ; Anti-emetic ; Anticipatory nausea ; Behavior, Animal - physiology ; Behavioral psychophysiology ; Biological and medical sciences ; CBD ; Conditioning, Classical - physiology ; Context ; Cues ; Data Interpretation, Statistical ; Fundamental and applied biological sciences. Psychology ; Gaping ; Lithium ; Lithium Chloride - adverse effects ; Male ; Medical sciences ; Motion Sickness - psychology ; Nausea - psychology ; Neuropharmacology ; Odorants ; Pharmacology. Drug treatments ; Physical Stimulation ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychology. 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This phase of nausea has been interpreted as a classically conditioned response where a conditional association develops between the contextual clinic cues and the nausea and/or vomiting that developed following treatment. Although rats do not vomit, they display a distinctive gaping reaction when exposed a flavored solution previously paired with a toxin. Here we report that, even in the absence of a flavored solution, rats display conditioned gaping reactions during exposure to a distinctive context previously paired with a high dose of lithium (Experiment 1 with a distinctive odor and Experiment 3 without a distinctive odor), a low dose of lithium (Experiment 2) or provocative vestibular stimulation (Experiment 2). These results suggest that the conditioned gaping reaction in rats is selectively elicited by nausea-paired contextual stimuli, as well as flavors. This rat model of anticipatory nausea may serve as a valuable preclinical tool to evaluate the effectiveness of anti-nausea treatments and the side effect of nausea produced by newly developed pharmaceutical compounds intended for other clinical treatments.</description><subject>Animals</subject><subject>Anti-emetic</subject><subject>Anticipatory nausea</subject><subject>Behavior, Animal - physiology</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>CBD</subject><subject>Conditioning, Classical - physiology</subject><subject>Context</subject><subject>Cues</subject><subject>Data Interpretation, Statistical</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gaping</subject><subject>Lithium</subject><subject>Lithium Chloride - adverse effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Motion Sickness - psychology</subject><subject>Nausea - psychology</subject><subject>Neuropharmacology</subject><subject>Odorants</subject><subject>Pharmacology. Drug treatments</subject><subject>Physical Stimulation</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Psychopharmacology</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rotation</subject><subject>Taste - drug effects</subject><subject>Vestibule, Labyrinth - physiology</subject><subject>Vomiting, Anticipatory - psychology</subject><issn>0166-4328</issn><issn>1872-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi0EokvhB3BBvsAtwXacxIZTVZUPqRIXOFsTZ1y8ysbBdtouvx6vNlJvnOYwz_tq5iHkLWc1Z7z7uK-HIdaCsb5mqmZCPiM7rnpR9a3Uz8muMF0lG6EuyKuU9owxyVr-klzwXum-b8SO_L15XEJaI9IcKFAb5oyPmS4R731Y03SkkFKwHjKO9MHn33SGNSFQnLz1OZ0So88-zGV_B4uf76ifaYScPtEreggjTjQ4CnMu_AI5xONW8Zq8cDAlfLPNS_Lry83P62_V7Y-v36-vbisrmz5XXClkzg1qkKJrsAMnhFDQSOyk08B4axm0LbhhHBo9dL2UTmkULXRctUw0l-TDuXeJ4c-KKZuDTxanCWYsLxrBZKe16grIz6CNIaWIzizRHyAeDWfmJNzsTRFuTsINU6YIL5l3W_k6HHB8SmyGC_B-AyBZmFyE2fr0xGnd9kyeuM9nDouKe4_RJOtxtjj6iDabMfj_nPEP7y-fwg</recordid><startdate>20080211</startdate><enddate>20080211</enddate><creator>Limebeer, Cheryl L.</creator><creator>Krohn, Jon P.</creator><creator>Cross-Mellor, Shelley</creator><creator>Litt, Devin E.</creator><creator>Ossenkopp, Klaus-Peter</creator><creator>Parker, Linda A.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope></search><sort><creationdate>20080211</creationdate><title>Exposure to a context previously associated with nausea elicits conditioned gaping in rats: A model of anticipatory nausea</title><author>Limebeer, Cheryl L. ; Krohn, Jon P. ; Cross-Mellor, Shelley ; Litt, Devin E. ; Ossenkopp, Klaus-Peter ; Parker, Linda A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-188e0ffb8b4263e6af2228a34e64f9a015c0a55afbdb39b6744f89e25a6185023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Anti-emetic</topic><topic>Anticipatory nausea</topic><topic>Behavior, Animal - physiology</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>CBD</topic><topic>Conditioning, Classical - physiology</topic><topic>Context</topic><topic>Cues</topic><topic>Data Interpretation, Statistical</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gaping</topic><topic>Lithium</topic><topic>Lithium Chloride - adverse effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Motion Sickness - psychology</topic><topic>Nausea - psychology</topic><topic>Neuropharmacology</topic><topic>Odorants</topic><topic>Pharmacology. Drug treatments</topic><topic>Physical Stimulation</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Psychopharmacology</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Rotation</topic><topic>Taste - drug effects</topic><topic>Vestibule, Labyrinth - physiology</topic><topic>Vomiting, Anticipatory - psychology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Limebeer, Cheryl L.</creatorcontrib><creatorcontrib>Krohn, Jon P.</creatorcontrib><creatorcontrib>Cross-Mellor, Shelley</creatorcontrib><creatorcontrib>Litt, Devin E.</creatorcontrib><creatorcontrib>Ossenkopp, Klaus-Peter</creatorcontrib><creatorcontrib>Parker, Linda A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><jtitle>Behavioural brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Limebeer, Cheryl L.</au><au>Krohn, Jon P.</au><au>Cross-Mellor, Shelley</au><au>Litt, Devin E.</au><au>Ossenkopp, Klaus-Peter</au><au>Parker, Linda A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exposure to a context previously associated with nausea elicits conditioned gaping in rats: A model of anticipatory nausea</atitle><jtitle>Behavioural brain research</jtitle><addtitle>Behav Brain Res</addtitle><date>2008-02-11</date><risdate>2008</risdate><volume>187</volume><issue>1</issue><spage>33</spage><epage>40</epage><pages>33-40</pages><issn>0166-4328</issn><eissn>1872-7549</eissn><coden>BBREDI</coden><abstract>Following one or more chemotherapy treatments, many patients report that they experience anticipatory nausea. This phase of nausea has been interpreted as a classically conditioned response where a conditional association develops between the contextual clinic cues and the nausea and/or vomiting that developed following treatment. Although rats do not vomit, they display a distinctive gaping reaction when exposed a flavored solution previously paired with a toxin. Here we report that, even in the absence of a flavored solution, rats display conditioned gaping reactions during exposure to a distinctive context previously paired with a high dose of lithium (Experiment 1 with a distinctive odor and Experiment 3 without a distinctive odor), a low dose of lithium (Experiment 2) or provocative vestibular stimulation (Experiment 2). These results suggest that the conditioned gaping reaction in rats is selectively elicited by nausea-paired contextual stimuli, as well as flavors. 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| subjects | Animals Anti-emetic Anticipatory nausea Behavior, Animal - physiology Behavioral psychophysiology Biological and medical sciences CBD Conditioning, Classical - physiology Context Cues Data Interpretation, Statistical Fundamental and applied biological sciences. Psychology Gaping Lithium Lithium Chloride - adverse effects Male Medical sciences Motion Sickness - psychology Nausea - psychology Neuropharmacology Odorants Pharmacology. Drug treatments Physical Stimulation Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopharmacology Rat Rats Rats, Sprague-Dawley Rotation Taste - drug effects Vestibule, Labyrinth - physiology Vomiting, Anticipatory - psychology |
| title | Exposure to a context previously associated with nausea elicits conditioned gaping in rats: A model of anticipatory nausea |
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