First-Trimester Use of Selective Serotonin-Reuptake Inhibitors and the Risk of Birth Defects

In this large case–control study, the first-trimester use of selective serotonin-reuptake inhibitors (SSRIs) overall was not associated with significantly increased risks of craniosynostosis, omphalocele, or heart defects. Analyses of individual SSRIs revealed some significant associations; however,...

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Veröffentlicht in:	The New England journal of medicine 2007-06, Vol.356 (26), p.2675-2683
Hauptverfasser:	Louik, Carol, Lin, Angela E, Werler, Martha M, Hernández-Díaz, Sonia, Mitchell, Allen A
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities, Drug-Induced - epidemiology Abnormalities, Drug-Induced - etiology Antidepressants Biological and medical sciences Birth defects Case-Control Studies Craniosynostoses - chemically induced Craniosynostoses - epidemiology Depressive Disorder - drug therapy Epidemiology Female General aspects Heart Defects, Congenital - chemically induced Heart Defects, Congenital - epidemiology Hernia, Umbilical - chemically induced Hernia, Umbilical - epidemiology Humans Hypotheses Infant, Newborn Male Medical sciences Metabolic disorders Odds Ratio Pregnancy Pregnancy Complications - drug therapy Pregnancy Trimester, First Public health. Hygiene Public health. Hygiene-occupational medicine Risk Serotonin Uptake Inhibitors - adverse effects
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