Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells

In the clinic, chimeric antigen receptor–modified T (CAR T) cell therapy is frequently associated with life-threatening cytokine-release syndrome (CRS) and neurotoxicity. Understanding the nature of these pathologies and developing treatments for them are hampered by the lack of appropriate animal m...

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Veröffentlicht in:	Nature medicine 2018-06, Vol.24 (6), p.739-748
Hauptverfasser:	Norelli, Margherita, Camisa, Barbara, Barbiera, Giulia, Falcone, Laura, Purevdorj, Ayurzana, Genua, Marco, Sanvito, Francesca, Ponzoni, Maurilio, Doglioni, Claudio, Cristofori, Patrizia, Traversari, Catia, Bordignon, Claudio, Ciceri, Fabio, Ostuni, Renato, Bonini, Chiara, Casucci, Monica, Bondanza, Attilio
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1059/2325 692/308/1426 692/308/575 Animal models Antigens B cells Biomedical and Life Sciences Biomedicine Cancer Cancer Research Chimeric antigen receptors Cytokines Drug therapy Fever Health aspects Immunologic diseases Infectious Diseases Interleukin 1 Interleukin 1 receptor antagonist Interleukin 6 Interleukin 6 receptors Laboratory rats Leukemia Lymphocytes Lymphocytes T Metabolic Diseases Molecular Medicine Monocytes Neurosciences Neurotoxicity Risk factors T cells Tocilizumab
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