Ficus deltoidea Prevented Bone Loss in Preclinical Osteoporosis/Osteoarthritis Model by Suppressing Inflammation
Osteoporosis (OP) and osteoarthritis (OA) are debilitating musculoskeletal diseases of the elderly. Ficus deltoidea (FD) or mistletoe fig, a medicinal plant, was pre-clinically evaluated against OP- and OA-related bone alterations, in postmenopausal OA rat model. Thirty twelfth-week-old female rats...
Gespeichert in:
| Veröffentlicht in: | Calcified tissue international 2018-10, Vol.103 (4), p.388-399 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 399 |
|---|---|
| container_issue | 4 |
| container_start_page | 388 |
| container_title | Calcified tissue international |
| container_volume | 103 |
| creator | Che Ahmad Tantowi, Nur Adeelah Lau, Seng Fong Mohamed, Suhaila |
| description | Osteoporosis (OP) and osteoarthritis (OA) are debilitating musculoskeletal diseases of the elderly.
Ficus deltoidea
(FD) or mistletoe fig, a medicinal plant, was pre-clinically evaluated against OP- and OA-related bone alterations, in postmenopausal OA rat model. Thirty twelfth-week-old female rats were divided into groups (
n
= 6). Four groups were bilateral ovariectomized (OVX) and OA-induced by intra-articular monosodium iodoacetate (MIA) injection into the right knee joints. The Sham control and OVX-OA non-treated groups were given deionized water. The three other OVX-OA groups were orally administered daily with FD extract (200, 400 mg/kg) or diclofenac (5 mg/kg) for 4 weeks. The rats’ bones and blood were evaluated for protein and mRNA expressions of osteoporosis and inflammatory indicators, and micro-CT computed tomography for bone microstructure. The non-treated OVX-OA rats developed severe OP bone loss and bone microstructural damage in the subchondral and metaphyseal regions, supported by reduced serum bone formation markers (osteocalcin, osteoprotegerin) and increased bone resorption markers (RANKL and CTX-I). The FD extract significantly (
p
|
| doi_str_mv | 10.1007/s00223-018-0433-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2046605447</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2045809446</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-ea19c96d109a1b00754a3892b6822ec62e265be11ed81a3f51e1a1a186963e143</originalsourceid><addsrcrecordid>eNp1kVFrFTEQhYMo9lr9Ab5IwBdf1maSbDb7qKXVwpUKreBbyO7OrSm7yZrZFfrvzfVWCwXJQ0jyzZnMOYy9BvEehGhOSAgpVSXAVkIrVcETtgGtZCWsbJ6yjYAGqtY034_YC6JbIUAbY56zI9laYVWjN2w-D_1KfMBxSWFAz79m_IVxwYF_TBH5NhHxEPfX_Rhi6P3IL2nBNKecKNDJn4PPy48clkD8SypSvLvjV-s8ZyQK8YZfxN3op8kvIcWX7NnOj4Sv7vdj9u387Pr0c7W9_HRx-mFb9aqRS4Ue2r41A4jWQ1eGrbVXtpWdsVJibyRKU3cIgIMFr3Y1IPiyrGmNwmLCMXt30J1z-rkiLW4K1OM4-ohpJSdF8ULUWjcFffsIvU1rjuV3e6q2otXaFAoOVF8Gp4w7N-cw-XznQLh9HO4QhytxuH0cDkrNm3vltZtw-Ffx1_8CyANA5SneYH5o_X_V33O1laA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2045809446</pqid></control><display><type>article</type><title>Ficus deltoidea Prevented Bone Loss in Preclinical Osteoporosis/Osteoarthritis Model by Suppressing Inflammation</title><source>SpringerNature Journals</source><creator>Che Ahmad Tantowi, Nur Adeelah ; Lau, Seng Fong ; Mohamed, Suhaila</creator><creatorcontrib>Che Ahmad Tantowi, Nur Adeelah ; Lau, Seng Fong ; Mohamed, Suhaila</creatorcontrib><description>Osteoporosis (OP) and osteoarthritis (OA) are debilitating musculoskeletal diseases of the elderly.
Ficus deltoidea
(FD) or mistletoe fig, a medicinal plant, was pre-clinically evaluated against OP- and OA-related bone alterations, in postmenopausal OA rat model. Thirty twelfth-week-old female rats were divided into groups (
n
= 6). Four groups were bilateral ovariectomized (OVX) and OA-induced by intra-articular monosodium iodoacetate (MIA) injection into the right knee joints. The Sham control and OVX-OA non-treated groups were given deionized water. The three other OVX-OA groups were orally administered daily with FD extract (200, 400 mg/kg) or diclofenac (5 mg/kg) for 4 weeks. The rats’ bones and blood were evaluated for protein and mRNA expressions of osteoporosis and inflammatory indicators, and micro-CT computed tomography for bone microstructure. The non-treated OVX-OA rats developed severe OP bone loss and bone microstructural damage in the subchondral and metaphyseal regions, supported by reduced serum bone formation markers (osteocalcin, osteoprotegerin) and increased bone resorption markers (RANKL and CTX-I). The FD extract significantly (
p
< 0.05) mitigated these bone microstructural and biomarker changes by dose-dependently down-regulating pro-inflammatory NF-κβ, TNF-α, and IL-6 mRNA expressions. The FD extract demonstrated good anti-osteoporotic properties in this OP/OA preclinical model by stimulating bone formation and suppressing bone resorption via anti-inflammatory pathways. This is among the few reports relating the subchondral bone plate and trabecular thickening with the metaphyseal trabecular osteopenic bone loss under osteoporotic-osteoarthritis conditions, providing some insights on the debated inverse relationship between osteoporosis and osteoarthritis.</description><identifier>ISSN: 0171-967X</identifier><identifier>EISSN: 1432-0827</identifier><identifier>DOI: 10.1007/s00223-018-0433-1</identifier><identifier>PMID: 29808374</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Arthritis ; Biochemistry ; Biomedical and Life Sciences ; Bone growth ; Bone loss ; Bone resorption ; Cancellous bone ; Cell Biology ; Collagen ; Computed tomography ; Diclofenac ; Endocrinology ; Ficus deltoidea ; Geriatrics ; Inflammation ; Interleukin 6 ; Joint diseases ; Knee ; Life Sciences ; Medicinal plants ; mRNA ; Oral administration ; Original Research ; Orthopedics ; Osteoarthritis ; Osteocalcin ; Osteogenesis ; Osteoporosis ; Osteoprotegerin ; Ovariectomy ; Post-menopause ; Rodents ; Subchondral bone ; TRANCE protein</subject><ispartof>Calcified tissue international, 2018-10, Vol.103 (4), p.388-399</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>Calcified Tissue International is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-ea19c96d109a1b00754a3892b6822ec62e265be11ed81a3f51e1a1a186963e143</citedby><cites>FETCH-LOGICAL-c372t-ea19c96d109a1b00754a3892b6822ec62e265be11ed81a3f51e1a1a186963e143</cites><orcidid>0000-0002-2954-3821</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00223-018-0433-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00223-018-0433-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29808374$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Che Ahmad Tantowi, Nur Adeelah</creatorcontrib><creatorcontrib>Lau, Seng Fong</creatorcontrib><creatorcontrib>Mohamed, Suhaila</creatorcontrib><title>Ficus deltoidea Prevented Bone Loss in Preclinical Osteoporosis/Osteoarthritis Model by Suppressing Inflammation</title><title>Calcified tissue international</title><addtitle>Calcif Tissue Int</addtitle><addtitle>Calcif Tissue Int</addtitle><description>Osteoporosis (OP) and osteoarthritis (OA) are debilitating musculoskeletal diseases of the elderly.
Ficus deltoidea
(FD) or mistletoe fig, a medicinal plant, was pre-clinically evaluated against OP- and OA-related bone alterations, in postmenopausal OA rat model. Thirty twelfth-week-old female rats were divided into groups (
n
= 6). Four groups were bilateral ovariectomized (OVX) and OA-induced by intra-articular monosodium iodoacetate (MIA) injection into the right knee joints. The Sham control and OVX-OA non-treated groups were given deionized water. The three other OVX-OA groups were orally administered daily with FD extract (200, 400 mg/kg) or diclofenac (5 mg/kg) for 4 weeks. The rats’ bones and blood were evaluated for protein and mRNA expressions of osteoporosis and inflammatory indicators, and micro-CT computed tomography for bone microstructure. The non-treated OVX-OA rats developed severe OP bone loss and bone microstructural damage in the subchondral and metaphyseal regions, supported by reduced serum bone formation markers (osteocalcin, osteoprotegerin) and increased bone resorption markers (RANKL and CTX-I). The FD extract significantly (
p
< 0.05) mitigated these bone microstructural and biomarker changes by dose-dependently down-regulating pro-inflammatory NF-κβ, TNF-α, and IL-6 mRNA expressions. The FD extract demonstrated good anti-osteoporotic properties in this OP/OA preclinical model by stimulating bone formation and suppressing bone resorption via anti-inflammatory pathways. This is among the few reports relating the subchondral bone plate and trabecular thickening with the metaphyseal trabecular osteopenic bone loss under osteoporotic-osteoarthritis conditions, providing some insights on the debated inverse relationship between osteoporosis and osteoarthritis.</description><subject>Arthritis</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Bone growth</subject><subject>Bone loss</subject><subject>Bone resorption</subject><subject>Cancellous bone</subject><subject>Cell Biology</subject><subject>Collagen</subject><subject>Computed tomography</subject><subject>Diclofenac</subject><subject>Endocrinology</subject><subject>Ficus deltoidea</subject><subject>Geriatrics</subject><subject>Inflammation</subject><subject>Interleukin 6</subject><subject>Joint diseases</subject><subject>Knee</subject><subject>Life Sciences</subject><subject>Medicinal plants</subject><subject>mRNA</subject><subject>Oral administration</subject><subject>Original Research</subject><subject>Orthopedics</subject><subject>Osteoarthritis</subject><subject>Osteocalcin</subject><subject>Osteogenesis</subject><subject>Osteoporosis</subject><subject>Osteoprotegerin</subject><subject>Ovariectomy</subject><subject>Post-menopause</subject><subject>Rodents</subject><subject>Subchondral bone</subject><subject>TRANCE protein</subject><issn>0171-967X</issn><issn>1432-0827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kVFrFTEQhYMo9lr9Ab5IwBdf1maSbDb7qKXVwpUKreBbyO7OrSm7yZrZFfrvzfVWCwXJQ0jyzZnMOYy9BvEehGhOSAgpVSXAVkIrVcETtgGtZCWsbJ6yjYAGqtY034_YC6JbIUAbY56zI9laYVWjN2w-D_1KfMBxSWFAz79m_IVxwYF_TBH5NhHxEPfX_Rhi6P3IL2nBNKecKNDJn4PPy48clkD8SypSvLvjV-s8ZyQK8YZfxN3op8kvIcWX7NnOj4Sv7vdj9u387Pr0c7W9_HRx-mFb9aqRS4Ue2r41A4jWQ1eGrbVXtpWdsVJibyRKU3cIgIMFr3Y1IPiyrGmNwmLCMXt30J1z-rkiLW4K1OM4-ohpJSdF8ULUWjcFffsIvU1rjuV3e6q2otXaFAoOVF8Gp4w7N-cw-XznQLh9HO4QhytxuH0cDkrNm3vltZtw-Ffx1_8CyANA5SneYH5o_X_V33O1laA</recordid><startdate>20181001</startdate><enddate>20181001</enddate><creator>Che Ahmad Tantowi, Nur Adeelah</creator><creator>Lau, Seng Fong</creator><creator>Mohamed, Suhaila</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2954-3821</orcidid></search><sort><creationdate>20181001</creationdate><title>Ficus deltoidea Prevented Bone Loss in Preclinical Osteoporosis/Osteoarthritis Model by Suppressing Inflammation</title><author>Che Ahmad Tantowi, Nur Adeelah ; Lau, Seng Fong ; Mohamed, Suhaila</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-ea19c96d109a1b00754a3892b6822ec62e265be11ed81a3f51e1a1a186963e143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Arthritis</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Bone growth</topic><topic>Bone loss</topic><topic>Bone resorption</topic><topic>Cancellous bone</topic><topic>Cell Biology</topic><topic>Collagen</topic><topic>Computed tomography</topic><topic>Diclofenac</topic><topic>Endocrinology</topic><topic>Ficus deltoidea</topic><topic>Geriatrics</topic><topic>Inflammation</topic><topic>Interleukin 6</topic><topic>Joint diseases</topic><topic>Knee</topic><topic>Life Sciences</topic><topic>Medicinal plants</topic><topic>mRNA</topic><topic>Oral administration</topic><topic>Original Research</topic><topic>Orthopedics</topic><topic>Osteoarthritis</topic><topic>Osteocalcin</topic><topic>Osteogenesis</topic><topic>Osteoporosis</topic><topic>Osteoprotegerin</topic><topic>Ovariectomy</topic><topic>Post-menopause</topic><topic>Rodents</topic><topic>Subchondral bone</topic><topic>TRANCE protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Che Ahmad Tantowi, Nur Adeelah</creatorcontrib><creatorcontrib>Lau, Seng Fong</creatorcontrib><creatorcontrib>Mohamed, Suhaila</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Calcified tissue international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Che Ahmad Tantowi, Nur Adeelah</au><au>Lau, Seng Fong</au><au>Mohamed, Suhaila</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ficus deltoidea Prevented Bone Loss in Preclinical Osteoporosis/Osteoarthritis Model by Suppressing Inflammation</atitle><jtitle>Calcified tissue international</jtitle><stitle>Calcif Tissue Int</stitle><addtitle>Calcif Tissue Int</addtitle><date>2018-10-01</date><risdate>2018</risdate><volume>103</volume><issue>4</issue><spage>388</spage><epage>399</epage><pages>388-399</pages><issn>0171-967X</issn><eissn>1432-0827</eissn><abstract>Osteoporosis (OP) and osteoarthritis (OA) are debilitating musculoskeletal diseases of the elderly.
Ficus deltoidea
(FD) or mistletoe fig, a medicinal plant, was pre-clinically evaluated against OP- and OA-related bone alterations, in postmenopausal OA rat model. Thirty twelfth-week-old female rats were divided into groups (
n
= 6). Four groups were bilateral ovariectomized (OVX) and OA-induced by intra-articular monosodium iodoacetate (MIA) injection into the right knee joints. The Sham control and OVX-OA non-treated groups were given deionized water. The three other OVX-OA groups were orally administered daily with FD extract (200, 400 mg/kg) or diclofenac (5 mg/kg) for 4 weeks. The rats’ bones and blood were evaluated for protein and mRNA expressions of osteoporosis and inflammatory indicators, and micro-CT computed tomography for bone microstructure. The non-treated OVX-OA rats developed severe OP bone loss and bone microstructural damage in the subchondral and metaphyseal regions, supported by reduced serum bone formation markers (osteocalcin, osteoprotegerin) and increased bone resorption markers (RANKL and CTX-I). The FD extract significantly (
p
< 0.05) mitigated these bone microstructural and biomarker changes by dose-dependently down-regulating pro-inflammatory NF-κβ, TNF-α, and IL-6 mRNA expressions. The FD extract demonstrated good anti-osteoporotic properties in this OP/OA preclinical model by stimulating bone formation and suppressing bone resorption via anti-inflammatory pathways. This is among the few reports relating the subchondral bone plate and trabecular thickening with the metaphyseal trabecular osteopenic bone loss under osteoporotic-osteoarthritis conditions, providing some insights on the debated inverse relationship between osteoporosis and osteoarthritis.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>29808374</pmid><doi>10.1007/s00223-018-0433-1</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-2954-3821</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0171-967X |
| ispartof | Calcified tissue international, 2018-10, Vol.103 (4), p.388-399 |
| issn | 0171-967X 1432-0827 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2046605447 |
| source | SpringerNature Journals |
| subjects | Arthritis Biochemistry Biomedical and Life Sciences Bone growth Bone loss Bone resorption Cancellous bone Cell Biology Collagen Computed tomography Diclofenac Endocrinology Ficus deltoidea Geriatrics Inflammation Interleukin 6 Joint diseases Knee Life Sciences Medicinal plants mRNA Oral administration Original Research Orthopedics Osteoarthritis Osteocalcin Osteogenesis Osteoporosis Osteoprotegerin Ovariectomy Post-menopause Rodents Subchondral bone TRANCE protein |
| title | Ficus deltoidea Prevented Bone Loss in Preclinical Osteoporosis/Osteoarthritis Model by Suppressing Inflammation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T01%3A22%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Ficus%20deltoidea%20Prevented%20Bone%20Loss%20in%20Preclinical%20Osteoporosis/Osteoarthritis%20Model%20by%20Suppressing%20Inflammation&rft.jtitle=Calcified%20tissue%20international&rft.au=Che%20Ahmad%20Tantowi,%20Nur%20Adeelah&rft.date=2018-10-01&rft.volume=103&rft.issue=4&rft.spage=388&rft.epage=399&rft.pages=388-399&rft.issn=0171-967X&rft.eissn=1432-0827&rft_id=info:doi/10.1007/s00223-018-0433-1&rft_dat=%3Cproquest_cross%3E2045809446%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2045809446&rft_id=info:pmid/29808374&rfr_iscdi=true |