Total Synthesis of the Nonribosomal Peptide Surugamide B and Identification of a New Offloading Cyclase Family

The cathepsin B inhibitor surugamide B (2), along with structurally related derivatives (A and C–E), has previously been isolated from the marine actinomycete Streptomyces sp. JAMM992. The biosynthetic genes are unexpectedly part of a cluster of four non‐ribosomal peptide synthetase (NRPS) genes, tw...

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Veröffentlicht in:	Angewandte Chemie International Edition 2018-07, Vol.57 (30), p.9447-9451
Hauptverfasser:	Kuranaga, Takefumi, Matsuda, Kenichi, Sano, Ayae, Kobayashi, Masakazu, Ninomiya, Akihiro, Takada, Kentaro, Matsunaga, Shigeki, Wakimoto, Toshiyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Biomimetics Biosynthesis Cathepsin B Genes macrocyclization NRPS Organic chemistry Penicillin penicillin-binding protein Peptides Proteins surugamide Thioesterase total synthesis
Online-Zugang:	Volltext
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