Treatment and outcome data of very low birth weight infants treated with less invasive surfactant administration in comparison to intubation and mechanical ventilation in the clinical setting of a cross-sectional observational multicenter study
The aim of this study was to contribute further to existing randomized controlled trials and meta-analyses showing advantages in the outcome of less invasive surfactant administration (LISA)-treated infants and add new aspects concerning treatment and outcome data collected in the routine clinical s...
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| Veröffentlicht in: | European journal of pediatrics 2018-08, Vol.177 (8), p.1207-1217 |
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| creator | Langhammer, Kristina Roth, Bernhard Kribs, Angela Göpel, Wolfgang Kuntz, Ludwig Miedaner, Felix |
| description | The aim of this study was to contribute further to existing randomized controlled trials and meta-analyses showing advantages in the outcome of less invasive surfactant administration (LISA)-treated infants and add new aspects concerning treatment and outcome data collected in the routine clinical setting. Four hundred seven very low birth weight infants who received surfactant via either LISA or intubation methods were enrolled in the observational cross-sectional multicenter study. To compare infants in terms of surfactant administration, we used an exact matching procedure (the same gestational age, severe perinatal depression (pH |
| doi_str_mv | 10.1007/s00431-018-3179-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2046605435</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2046605435</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-4729eff452c2dd796ef8dabb44c5d0a3cc8ff8ba1e9581cd39e6cf66942256ca3</originalsourceid><addsrcrecordid>eNp1ks1u1DAUhSMEokPhAdggS2y6Cfgnf16iCgpSJTZlHTn29YyrxB58nZnOe_MAOM1QJCRWln2-c-61dIriLaMfGKXtR6S0EqykrCsFa2X58KzYsErwktG2eV5sqKho2TApL4pXiPc0eyTrXhYXXHa046LdFL_uIqg0gU9EeUPCnHSYgBiVFAmWHCCeyBiOZHAx7cgR3HaXiPNW-YQkLV4w5OiyNgJiVg4K3QEIztEqndSSaybnHaaokgs-IySP2KvoMN9SyA9pHlZtWWECvVPeaTXm6T658cmWdkD06FYNISXnt8uSiugYEEsEvaBZDANCPKjzbZrH5HTOgkgwzeb0unhh1Yjw5nxeFj--fL67_lrefr_5dv3pttSi5amsWi7B2qrmmhvTygZsZ9QwVJWuDVVC687ablAMZN0xbYSERtumkRXndaOVuCyu1tx9DD9nwNRPDjWMo_IQZuw5rZqG1pWoM_r-H_Q-zDFv_0jl-E7WbabYSj1-OILt99FNKp56RvulEv1aiT5Xol8q0T9kz7tz8jxMYJ4cfzqQAb4CmCW_hfh39P9TfwOEF8sL</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2045818957</pqid></control><display><type>article</type><title>Treatment and outcome data of very low birth weight infants treated with less invasive surfactant administration in comparison to intubation and mechanical ventilation in the clinical setting of a cross-sectional observational multicenter study</title><source>SpringerLink Journals - AutoHoldings</source><creator>Langhammer, Kristina ; Roth, Bernhard ; Kribs, Angela ; Göpel, Wolfgang ; Kuntz, Ludwig ; Miedaner, Felix</creator><creatorcontrib>Langhammer, Kristina ; Roth, Bernhard ; Kribs, Angela ; Göpel, Wolfgang ; Kuntz, Ludwig ; Miedaner, Felix</creatorcontrib><description>The aim of this study was to contribute further to existing randomized controlled trials and meta-analyses showing advantages in the outcome of less invasive surfactant administration (LISA)-treated infants and add new aspects concerning treatment and outcome data collected in the routine clinical setting. Four hundred seven very low birth weight infants who received surfactant via either LISA or intubation methods were enrolled in the observational cross-sectional multicenter study. To compare infants in terms of surfactant administration, we used an exact matching procedure (the same gestational age, severe perinatal depression (pH < 7.10), birth weight < 10th percentile, antenatal steroid treatment, and the same gender). To check for robustness, we performed repeated matching. LISA-treated infants required significantly less mechanical ventilation during hospital stay (
p
< 0.001) and days with supplemental oxygen (
p
= 0.03). Analgesics and sedatives were used less often during the stay (
p
< 0.001). Infants treated with LISA had significantly lower rates of bronchopulmonary dysplasia (
p
= 0.003). LISA failure infants were identified as more likely to be small for gestational age and more immature.
Conclusion
: Our study complements former results with advantages for LISA-treated infants in mechanical ventilation and bronchopulmonary dysplasia in the clinical routine.
Trial registration
: DRKS00004589
What is Known:
•
According to existing literature, LISA-treated infants seem to have some favors in terms of treatment and outcome data. Observational studies in routine clinical setting are missing.
What is New:
•
Data of 407 VLBW infants collected in routine clinical setting showed that LISA-treated infants needed less mechanical ventilation and fewer days with supplemental oxygen and less analgesics and sedatives. A reduced risk of BPD could be showed. SGA infants seem to have higher risks of LISA failure.</description><identifier>ISSN: 0340-6199</identifier><identifier>EISSN: 1432-1076</identifier><identifier>DOI: 10.1007/s00431-018-3179-x</identifier><identifier>PMID: 29808237</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Analgesics ; Anesthesia ; Birth weight ; Clinical trials ; Dysplasia ; Gestational age ; Infants ; Intubation ; Low birth weight ; Mechanical ventilation ; Medicine ; Medicine & Public Health ; Original Article ; Oxygen ; Pediatrics ; Sedatives ; Small for gestational age ; Surfactants ; Ventilation</subject><ispartof>European journal of pediatrics, 2018-08, Vol.177 (8), p.1207-1217</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2018</rights><rights>European Journal of Pediatrics is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-4729eff452c2dd796ef8dabb44c5d0a3cc8ff8ba1e9581cd39e6cf66942256ca3</citedby><cites>FETCH-LOGICAL-c372t-4729eff452c2dd796ef8dabb44c5d0a3cc8ff8ba1e9581cd39e6cf66942256ca3</cites><orcidid>0000-0002-5118-1994</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00431-018-3179-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00431-018-3179-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29808237$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Langhammer, Kristina</creatorcontrib><creatorcontrib>Roth, Bernhard</creatorcontrib><creatorcontrib>Kribs, Angela</creatorcontrib><creatorcontrib>Göpel, Wolfgang</creatorcontrib><creatorcontrib>Kuntz, Ludwig</creatorcontrib><creatorcontrib>Miedaner, Felix</creatorcontrib><title>Treatment and outcome data of very low birth weight infants treated with less invasive surfactant administration in comparison to intubation and mechanical ventilation in the clinical setting of a cross-sectional observational multicenter study</title><title>European journal of pediatrics</title><addtitle>Eur J Pediatr</addtitle><addtitle>Eur J Pediatr</addtitle><description>The aim of this study was to contribute further to existing randomized controlled trials and meta-analyses showing advantages in the outcome of less invasive surfactant administration (LISA)-treated infants and add new aspects concerning treatment and outcome data collected in the routine clinical setting. Four hundred seven very low birth weight infants who received surfactant via either LISA or intubation methods were enrolled in the observational cross-sectional multicenter study. To compare infants in terms of surfactant administration, we used an exact matching procedure (the same gestational age, severe perinatal depression (pH < 7.10), birth weight < 10th percentile, antenatal steroid treatment, and the same gender). To check for robustness, we performed repeated matching. LISA-treated infants required significantly less mechanical ventilation during hospital stay (
p
< 0.001) and days with supplemental oxygen (
p
= 0.03). Analgesics and sedatives were used less often during the stay (
p
< 0.001). Infants treated with LISA had significantly lower rates of bronchopulmonary dysplasia (
p
= 0.003). LISA failure infants were identified as more likely to be small for gestational age and more immature.
Conclusion
: Our study complements former results with advantages for LISA-treated infants in mechanical ventilation and bronchopulmonary dysplasia in the clinical routine.
Trial registration
: DRKS00004589
What is Known:
•
According to existing literature, LISA-treated infants seem to have some favors in terms of treatment and outcome data. Observational studies in routine clinical setting are missing.
What is New:
•
Data of 407 VLBW infants collected in routine clinical setting showed that LISA-treated infants needed less mechanical ventilation and fewer days with supplemental oxygen and less analgesics and sedatives. A reduced risk of BPD could be showed. SGA infants seem to have higher risks of LISA failure.</description><subject>Analgesics</subject><subject>Anesthesia</subject><subject>Birth weight</subject><subject>Clinical trials</subject><subject>Dysplasia</subject><subject>Gestational age</subject><subject>Infants</subject><subject>Intubation</subject><subject>Low birth weight</subject><subject>Mechanical ventilation</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Oxygen</subject><subject>Pediatrics</subject><subject>Sedatives</subject><subject>Small for gestational age</subject><subject>Surfactants</subject><subject>Ventilation</subject><issn>0340-6199</issn><issn>1432-1076</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1ks1u1DAUhSMEokPhAdggS2y6Cfgnf16iCgpSJTZlHTn29YyrxB58nZnOe_MAOM1QJCRWln2-c-61dIriLaMfGKXtR6S0EqykrCsFa2X58KzYsErwktG2eV5sqKho2TApL4pXiPc0eyTrXhYXXHa046LdFL_uIqg0gU9EeUPCnHSYgBiVFAmWHCCeyBiOZHAx7cgR3HaXiPNW-YQkLV4w5OiyNgJiVg4K3QEIztEqndSSaybnHaaokgs-IySP2KvoMN9SyA9pHlZtWWECvVPeaTXm6T658cmWdkD06FYNISXnt8uSiugYEEsEvaBZDANCPKjzbZrH5HTOgkgwzeb0unhh1Yjw5nxeFj--fL67_lrefr_5dv3pttSi5amsWi7B2qrmmhvTygZsZ9QwVJWuDVVC687ablAMZN0xbYSERtumkRXndaOVuCyu1tx9DD9nwNRPDjWMo_IQZuw5rZqG1pWoM_r-H_Q-zDFv_0jl-E7WbabYSj1-OILt99FNKp56RvulEv1aiT5Xol8q0T9kz7tz8jxMYJ4cfzqQAb4CmCW_hfh39P9TfwOEF8sL</recordid><startdate>20180801</startdate><enddate>20180801</enddate><creator>Langhammer, Kristina</creator><creator>Roth, Bernhard</creator><creator>Kribs, Angela</creator><creator>Göpel, Wolfgang</creator><creator>Kuntz, Ludwig</creator><creator>Miedaner, Felix</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5118-1994</orcidid></search><sort><creationdate>20180801</creationdate><title>Treatment and outcome data of very low birth weight infants treated with less invasive surfactant administration in comparison to intubation and mechanical ventilation in the clinical setting of a cross-sectional observational multicenter study</title><author>Langhammer, Kristina ; Roth, Bernhard ; Kribs, Angela ; Göpel, Wolfgang ; Kuntz, Ludwig ; Miedaner, Felix</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-4729eff452c2dd796ef8dabb44c5d0a3cc8ff8ba1e9581cd39e6cf66942256ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Analgesics</topic><topic>Anesthesia</topic><topic>Birth weight</topic><topic>Clinical trials</topic><topic>Dysplasia</topic><topic>Gestational age</topic><topic>Infants</topic><topic>Intubation</topic><topic>Low birth weight</topic><topic>Mechanical ventilation</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Oxygen</topic><topic>Pediatrics</topic><topic>Sedatives</topic><topic>Small for gestational age</topic><topic>Surfactants</topic><topic>Ventilation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Langhammer, Kristina</creatorcontrib><creatorcontrib>Roth, Bernhard</creatorcontrib><creatorcontrib>Kribs, Angela</creatorcontrib><creatorcontrib>Göpel, Wolfgang</creatorcontrib><creatorcontrib>Kuntz, Ludwig</creatorcontrib><creatorcontrib>Miedaner, Felix</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Langhammer, Kristina</au><au>Roth, Bernhard</au><au>Kribs, Angela</au><au>Göpel, Wolfgang</au><au>Kuntz, Ludwig</au><au>Miedaner, Felix</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment and outcome data of very low birth weight infants treated with less invasive surfactant administration in comparison to intubation and mechanical ventilation in the clinical setting of a cross-sectional observational multicenter study</atitle><jtitle>European journal of pediatrics</jtitle><stitle>Eur J Pediatr</stitle><addtitle>Eur J Pediatr</addtitle><date>2018-08-01</date><risdate>2018</risdate><volume>177</volume><issue>8</issue><spage>1207</spage><epage>1217</epage><pages>1207-1217</pages><issn>0340-6199</issn><eissn>1432-1076</eissn><abstract>The aim of this study was to contribute further to existing randomized controlled trials and meta-analyses showing advantages in the outcome of less invasive surfactant administration (LISA)-treated infants and add new aspects concerning treatment and outcome data collected in the routine clinical setting. Four hundred seven very low birth weight infants who received surfactant via either LISA or intubation methods were enrolled in the observational cross-sectional multicenter study. To compare infants in terms of surfactant administration, we used an exact matching procedure (the same gestational age, severe perinatal depression (pH < 7.10), birth weight < 10th percentile, antenatal steroid treatment, and the same gender). To check for robustness, we performed repeated matching. LISA-treated infants required significantly less mechanical ventilation during hospital stay (
p
< 0.001) and days with supplemental oxygen (
p
= 0.03). Analgesics and sedatives were used less often during the stay (
p
< 0.001). Infants treated with LISA had significantly lower rates of bronchopulmonary dysplasia (
p
= 0.003). LISA failure infants were identified as more likely to be small for gestational age and more immature.
Conclusion
: Our study complements former results with advantages for LISA-treated infants in mechanical ventilation and bronchopulmonary dysplasia in the clinical routine.
Trial registration
: DRKS00004589
What is Known:
•
According to existing literature, LISA-treated infants seem to have some favors in terms of treatment and outcome data. Observational studies in routine clinical setting are missing.
What is New:
•
Data of 407 VLBW infants collected in routine clinical setting showed that LISA-treated infants needed less mechanical ventilation and fewer days with supplemental oxygen and less analgesics and sedatives. A reduced risk of BPD could be showed. SGA infants seem to have higher risks of LISA failure.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>29808237</pmid><doi>10.1007/s00431-018-3179-x</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-5118-1994</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | European journal of pediatrics, 2018-08, Vol.177 (8), p.1207-1217 |
| issn | 0340-6199 1432-1076 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2046605435 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Analgesics Anesthesia Birth weight Clinical trials Dysplasia Gestational age Infants Intubation Low birth weight Mechanical ventilation Medicine Medicine & Public Health Original Article Oxygen Pediatrics Sedatives Small for gestational age Surfactants Ventilation |
| title | Treatment and outcome data of very low birth weight infants treated with less invasive surfactant administration in comparison to intubation and mechanical ventilation in the clinical setting of a cross-sectional observational multicenter study |
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