Fluorescence-Guided Bone Resection in Bisphosphonate-Associated Osteonecrosis of the Jaws
Purpose To date, the therapy of bisphosphonate-associated osteonecrosis of the jaws (BONJ) has been hampered by the lack of imaging modalities that enable the extent of necrosis to be visualized. This study aims to demonstrate the feasibility of tetracycline fluorescence guided bone resection in the...
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| Veröffentlicht in: | Journal of oral and maxillofacial surgery 2009-03, Vol.67 (3), p.471-476 |
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| creator | Pautke, Christoph, MD, DDS Bauer, Florian, MD, DDS Tischer, Thomas, MD Kreutzer, Kilian, MD, DDS Weitz, Jochen, MD, DDS Kesting, Marco, MD, DDS Hölzle, Frank, MD, DDS Kolk, Andreas, MD, DDS Stürzenbaum, Stephen R., PhD Wolff, Klaus-Dietrich, MD, DDS |
| description | Purpose To date, the therapy of bisphosphonate-associated osteonecrosis of the jaws (BONJ) has been hampered by the lack of imaging modalities that enable the extent of necrosis to be visualized. This study aims to demonstrate the feasibility of tetracycline fluorescence guided bone resection in the surgical management of BONJ. Patients and Methods Following a 10-day preoperative administration of doxycycline in patients suffering from BONJ, sufficient doxycycline is incorporated into viable bone to be visualized with a certified medical lamp emitting exciting light at 400 to 460 nm. Results Viable and necrotic bone can be discriminated intraoperatively in a routine and reproducible manner by doxycycline bone fluorescence. Conclusion In the therapy of BONJ, conservative concepts are to be favored. The fact that necrotic bone can now be selectively resected signifies an improvement of the conservative surgical therapy of BONJ. |
| doi_str_mv | 10.1016/j.joms.2008.09.037 |
| format | Article |
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This study aims to demonstrate the feasibility of tetracycline fluorescence guided bone resection in the surgical management of BONJ. Patients and Methods Following a 10-day preoperative administration of doxycycline in patients suffering from BONJ, sufficient doxycycline is incorporated into viable bone to be visualized with a certified medical lamp emitting exciting light at 400 to 460 nm. Results Viable and necrotic bone can be discriminated intraoperatively in a routine and reproducible manner by doxycycline bone fluorescence. Conclusion In the therapy of BONJ, conservative concepts are to be favored. The fact that necrotic bone can now be selectively resected signifies an improvement of the conservative surgical therapy of BONJ.</description><identifier>ISSN: 0278-2391</identifier><identifier>EISSN: 1531-5053</identifier><identifier>DOI: 10.1016/j.joms.2008.09.037</identifier><identifier>PMID: 19231768</identifier><identifier>CODEN: JOMSDA</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aged ; Biological and medical sciences ; Bone Density Conservation Agents - adverse effects ; Bones, joints and connective tissue. Antiinflammatory agents ; Cone-Beam Computed Tomography ; Diphosphonates - adverse effects ; Diseases of the osteoarticular system ; Feasibility Studies ; Female ; Fluorescence ; Fluorometry ; Humans ; Jaw - surgery ; Jaw Diseases - chemically induced ; Jaw Diseases - diagnostic imaging ; Jaw Diseases - surgery ; Light ; Male ; Medical sciences ; Oral Surgical Procedures - methods ; Osteonecrosis - chemically induced ; Osteonecrosis - diagnostic imaging ; Osteonecrosis - surgery ; Otorhinolaryngology. Stomatology ; Pharmacology. Drug treatments ; Surgery ; Tetracycline ; Vascular bone diseases</subject><ispartof>Journal of oral and maxillofacial surgery, 2009-03, Vol.67 (3), p.471-476</ispartof><rights>American Association of Oral and Maxillofacial Surgeons</rights><rights>2009 American Association of Oral and Maxillofacial Surgeons</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c496t-b74f8847c277b584718465575cafb0c051cc0110ec51e612179e8a1354513e4a3</citedby><cites>FETCH-LOGICAL-c496t-b74f8847c277b584718465575cafb0c051cc0110ec51e612179e8a1354513e4a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.joms.2008.09.037$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21205898$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19231768$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pautke, Christoph, MD, DDS</creatorcontrib><creatorcontrib>Bauer, Florian, MD, DDS</creatorcontrib><creatorcontrib>Tischer, Thomas, MD</creatorcontrib><creatorcontrib>Kreutzer, Kilian, MD, DDS</creatorcontrib><creatorcontrib>Weitz, Jochen, MD, DDS</creatorcontrib><creatorcontrib>Kesting, Marco, MD, DDS</creatorcontrib><creatorcontrib>Hölzle, Frank, MD, DDS</creatorcontrib><creatorcontrib>Kolk, Andreas, MD, DDS</creatorcontrib><creatorcontrib>Stürzenbaum, Stephen R., PhD</creatorcontrib><creatorcontrib>Wolff, Klaus-Dietrich, MD, DDS</creatorcontrib><title>Fluorescence-Guided Bone Resection in Bisphosphonate-Associated Osteonecrosis of the Jaws</title><title>Journal of oral and maxillofacial surgery</title><addtitle>J Oral Maxillofac Surg</addtitle><description>Purpose To date, the therapy of bisphosphonate-associated osteonecrosis of the jaws (BONJ) has been hampered by the lack of imaging modalities that enable the extent of necrosis to be visualized. This study aims to demonstrate the feasibility of tetracycline fluorescence guided bone resection in the surgical management of BONJ. Patients and Methods Following a 10-day preoperative administration of doxycycline in patients suffering from BONJ, sufficient doxycycline is incorporated into viable bone to be visualized with a certified medical lamp emitting exciting light at 400 to 460 nm. Results Viable and necrotic bone can be discriminated intraoperatively in a routine and reproducible manner by doxycycline bone fluorescence. Conclusion In the therapy of BONJ, conservative concepts are to be favored. The fact that necrotic bone can now be selectively resected signifies an improvement of the conservative surgical therapy of BONJ.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Bone Density Conservation Agents - adverse effects</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>Cone-Beam Computed Tomography</subject><subject>Diphosphonates - adverse effects</subject><subject>Diseases of the osteoarticular system</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Fluorescence</subject><subject>Fluorometry</subject><subject>Humans</subject><subject>Jaw - surgery</subject><subject>Jaw Diseases - chemically induced</subject><subject>Jaw Diseases - diagnostic imaging</subject><subject>Jaw Diseases - surgery</subject><subject>Light</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Oral Surgical Procedures - methods</subject><subject>Osteonecrosis - chemically induced</subject><subject>Osteonecrosis - diagnostic imaging</subject><subject>Osteonecrosis - surgery</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Pharmacology. Drug treatments</subject><subject>Surgery</subject><subject>Tetracycline</subject><subject>Vascular bone diseases</subject><issn>0278-2391</issn><issn>1531-5053</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhi0EotvCH-CAcoFbwowdx4mEkNqqLaBKlfg4cLK8zkR1yMZLJgH13-NoVyBx4GB5Ds-MXz8jxAuEAgGrN33Rxx0XEqAuoClAmUdig1phrkGrx2ID0tS5VA2eiFPmHgBRm-qpOMFGKjRVvRHfroclTsSeRk_5zRJaarOLOFL2iZj8HOKYhTG7CLy_j-sZ3Uz5OXP0IVVtdsczJdxPkQNnscvme8o-ul_8TDzp3MD0_Hifia_XV18u3-e3dzcfLs9vc1821ZxvTdnVdWm8NGarU4F1WWlttHfdFjxo9D7lBvIaqUKJpqHaodKlRkWlU2fi9WHufoo_FuLZ7kL6zjC4keLCVkKaV2mVQHkA16w8UWf3U9i56cEi2FWo7e0q1K5CLTQ2CU1NL4_Tl-2O2r8tR4MJeHUEHHs3dJMbfeA_nEQJum5W7u2Bo-TiZ6DJsg-r9DZMybNtY_h_jnf_tPshjCG9-J0eiPu4TGOybNGytGA_r6tfNw81oG50qX4D3dyoVg</recordid><startdate>20090301</startdate><enddate>20090301</enddate><creator>Pautke, Christoph, MD, DDS</creator><creator>Bauer, Florian, MD, DDS</creator><creator>Tischer, Thomas, MD</creator><creator>Kreutzer, Kilian, MD, DDS</creator><creator>Weitz, Jochen, MD, DDS</creator><creator>Kesting, Marco, MD, DDS</creator><creator>Hölzle, Frank, MD, DDS</creator><creator>Kolk, Andreas, MD, DDS</creator><creator>Stürzenbaum, Stephen R., PhD</creator><creator>Wolff, Klaus-Dietrich, MD, DDS</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope></search><sort><creationdate>20090301</creationdate><title>Fluorescence-Guided Bone Resection in Bisphosphonate-Associated Osteonecrosis of the Jaws</title><author>Pautke, Christoph, MD, DDS ; Bauer, Florian, MD, DDS ; Tischer, Thomas, MD ; Kreutzer, Kilian, MD, DDS ; Weitz, Jochen, MD, DDS ; Kesting, Marco, MD, DDS ; Hölzle, Frank, MD, DDS ; Kolk, Andreas, MD, DDS ; Stürzenbaum, Stephen R., PhD ; Wolff, Klaus-Dietrich, MD, DDS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c496t-b74f8847c277b584718465575cafb0c051cc0110ec51e612179e8a1354513e4a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Bone Density Conservation Agents - adverse effects</topic><topic>Bones, joints and connective tissue. Antiinflammatory agents</topic><topic>Cone-Beam Computed Tomography</topic><topic>Diphosphonates - adverse effects</topic><topic>Diseases of the osteoarticular system</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Fluorescence</topic><topic>Fluorometry</topic><topic>Humans</topic><topic>Jaw - surgery</topic><topic>Jaw Diseases - chemically induced</topic><topic>Jaw Diseases - diagnostic imaging</topic><topic>Jaw Diseases - surgery</topic><topic>Light</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Oral Surgical Procedures - methods</topic><topic>Osteonecrosis - chemically induced</topic><topic>Osteonecrosis - diagnostic imaging</topic><topic>Osteonecrosis - surgery</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Pharmacology. Drug treatments</topic><topic>Surgery</topic><topic>Tetracycline</topic><topic>Vascular bone diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pautke, Christoph, MD, DDS</creatorcontrib><creatorcontrib>Bauer, Florian, MD, DDS</creatorcontrib><creatorcontrib>Tischer, Thomas, MD</creatorcontrib><creatorcontrib>Kreutzer, Kilian, MD, DDS</creatorcontrib><creatorcontrib>Weitz, Jochen, MD, DDS</creatorcontrib><creatorcontrib>Kesting, Marco, MD, DDS</creatorcontrib><creatorcontrib>Hölzle, Frank, MD, DDS</creatorcontrib><creatorcontrib>Kolk, Andreas, MD, DDS</creatorcontrib><creatorcontrib>Stürzenbaum, Stephen R., PhD</creatorcontrib><creatorcontrib>Wolff, Klaus-Dietrich, MD, DDS</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>Journal of oral and maxillofacial surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pautke, Christoph, MD, DDS</au><au>Bauer, Florian, MD, DDS</au><au>Tischer, Thomas, MD</au><au>Kreutzer, Kilian, MD, DDS</au><au>Weitz, Jochen, MD, DDS</au><au>Kesting, Marco, MD, DDS</au><au>Hölzle, Frank, MD, DDS</au><au>Kolk, Andreas, MD, DDS</au><au>Stürzenbaum, Stephen R., PhD</au><au>Wolff, Klaus-Dietrich, MD, DDS</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fluorescence-Guided Bone Resection in Bisphosphonate-Associated Osteonecrosis of the Jaws</atitle><jtitle>Journal of oral and maxillofacial surgery</jtitle><addtitle>J Oral Maxillofac Surg</addtitle><date>2009-03-01</date><risdate>2009</risdate><volume>67</volume><issue>3</issue><spage>471</spage><epage>476</epage><pages>471-476</pages><issn>0278-2391</issn><eissn>1531-5053</eissn><coden>JOMSDA</coden><abstract>Purpose To date, the therapy of bisphosphonate-associated osteonecrosis of the jaws (BONJ) has been hampered by the lack of imaging modalities that enable the extent of necrosis to be visualized. This study aims to demonstrate the feasibility of tetracycline fluorescence guided bone resection in the surgical management of BONJ. Patients and Methods Following a 10-day preoperative administration of doxycycline in patients suffering from BONJ, sufficient doxycycline is incorporated into viable bone to be visualized with a certified medical lamp emitting exciting light at 400 to 460 nm. Results Viable and necrotic bone can be discriminated intraoperatively in a routine and reproducible manner by doxycycline bone fluorescence. Conclusion In the therapy of BONJ, conservative concepts are to be favored. The fact that necrotic bone can now be selectively resected signifies an improvement of the conservative surgical therapy of BONJ.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>19231768</pmid><doi>10.1016/j.joms.2008.09.037</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of oral and maxillofacial surgery, 2009-03, Vol.67 (3), p.471-476 |
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| subjects | Aged Biological and medical sciences Bone Density Conservation Agents - adverse effects Bones, joints and connective tissue. Antiinflammatory agents Cone-Beam Computed Tomography Diphosphonates - adverse effects Diseases of the osteoarticular system Feasibility Studies Female Fluorescence Fluorometry Humans Jaw - surgery Jaw Diseases - chemically induced Jaw Diseases - diagnostic imaging Jaw Diseases - surgery Light Male Medical sciences Oral Surgical Procedures - methods Osteonecrosis - chemically induced Osteonecrosis - diagnostic imaging Osteonecrosis - surgery Otorhinolaryngology. Stomatology Pharmacology. Drug treatments Surgery Tetracycline Vascular bone diseases |
| title | Fluorescence-Guided Bone Resection in Bisphosphonate-Associated Osteonecrosis of the Jaws |
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