The influence of small doses of paracetamol on rabbit liver
Paracetamol has properties that make it useful in many kinds of drugs that are readily available to users. These drugs are often used for extensive periods of time without a doctor's supervision, which might lead to unexpected overdose. The aim of this work was to assess the extent of liver dam...
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| Veröffentlicht in: | Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2007-10, Vol.59 (2), p.139-141 |
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| container_title | Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie |
| container_volume | 59 |
| creator | Maciejewska-Paszek, Izabela Pawłowska-Góral, Katarzyna Kostrzewski, Marek Kurzeja, Ewa Wardas, Maria Rzepecka-Stojko, Anna |
| description | Paracetamol has properties that make it useful in many kinds of drugs that are readily available to users. These drugs are often used for extensive periods of time without a doctor's supervision, which might lead to unexpected overdose. The aim of this work was to assess the extent of liver damage in rabbits after administering them with paracteamol for approximately 2 months. The results we obtained suggest that paracetamol administered for a long time causes liver function impairment. It was, however, not possible to determine the impairment by measuring the activity of aspartate aminotransferase (AST), alanine aminotransferase (ALT) or γ-glutamylotranspeptidase (GGTP). It was determined by measuring the concentration of ketone bodies and arterial ketone body ratio (AKBR) value. Even when taken in small doses, paracetamol causes changes in liver metabolism when taken for an extended period of time. |
| doi_str_mv | 10.1016/j.etp.2007.04.003 |
| format | Article |
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These drugs are often used for extensive periods of time without a doctor's supervision, which might lead to unexpected overdose. The aim of this work was to assess the extent of liver damage in rabbits after administering them with paracteamol for approximately 2 months. The results we obtained suggest that paracetamol administered for a long time causes liver function impairment. It was, however, not possible to determine the impairment by measuring the activity of aspartate aminotransferase (AST), alanine aminotransferase (ALT) or γ-glutamylotranspeptidase (GGTP). It was determined by measuring the concentration of ketone bodies and arterial ketone body ratio (AKBR) value. Even when taken in small doses, paracetamol causes changes in liver metabolism when taken for an extended period of time.</description><identifier>ISSN: 0940-2993</identifier><identifier>EISSN: 1618-1433</identifier><identifier>DOI: 10.1016/j.etp.2007.04.003</identifier><identifier>PMID: 17601712</identifier><language>eng</language><publisher>Jena: Elsevier GmbH</publisher><subject>3-Hydroxybutyric Acid - blood ; Acetaminophen - toxicity ; Acetoacetate ; Acetoacetates - blood ; Administration, Oral ; AKBR ; Alanine Transaminase - metabolism ; Analgesics, Non-Narcotic - toxicity ; Animals ; Aspartate Aminotransferases - metabolism ; Biological and medical sciences ; Chemical and Drug Induced Liver Injury - blood ; Chemical and Drug Induced Liver Injury - etiology ; Dose-Response Relationship, Drug ; gamma-Glutamyltransferase - metabolism ; Glutathione peroxidase ; Glutathione Peroxidase - blood ; Investigative techniques, diagnostic techniques (general aspects) ; Ketone Bodies - blood ; Liver - drug effects ; Liver - metabolism ; Liver - pathology ; Liver Function Tests ; Male ; Medical sciences ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Rabbits ; Superoxide dismutase ; Superoxide Dismutase - blood ; β-hydoxybutyrate</subject><ispartof>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie, 2007-10, Vol.59 (2), p.139-141</ispartof><rights>2007 Elsevier GmbH</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-91b7705d99bcc074904b0c415a2598502005a8155f2fd569f18436535c48c32b3</citedby><cites>FETCH-LOGICAL-c437t-91b7705d99bcc074904b0c415a2598502005a8155f2fd569f18436535c48c32b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0940299307000334$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19148003$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17601712$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maciejewska-Paszek, Izabela</creatorcontrib><creatorcontrib>Pawłowska-Góral, Katarzyna</creatorcontrib><creatorcontrib>Kostrzewski, Marek</creatorcontrib><creatorcontrib>Kurzeja, Ewa</creatorcontrib><creatorcontrib>Wardas, Maria</creatorcontrib><creatorcontrib>Rzepecka-Stojko, Anna</creatorcontrib><title>The influence of small doses of paracetamol on rabbit liver</title><title>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie</title><addtitle>Exp Toxicol Pathol</addtitle><description>Paracetamol has properties that make it useful in many kinds of drugs that are readily available to users. These drugs are often used for extensive periods of time without a doctor's supervision, which might lead to unexpected overdose. The aim of this work was to assess the extent of liver damage in rabbits after administering them with paracteamol for approximately 2 months. The results we obtained suggest that paracetamol administered for a long time causes liver function impairment. It was, however, not possible to determine the impairment by measuring the activity of aspartate aminotransferase (AST), alanine aminotransferase (ALT) or γ-glutamylotranspeptidase (GGTP). It was determined by measuring the concentration of ketone bodies and arterial ketone body ratio (AKBR) value. Even when taken in small doses, paracetamol causes changes in liver metabolism when taken for an extended period of time.</description><subject>3-Hydroxybutyric Acid - blood</subject><subject>Acetaminophen - toxicity</subject><subject>Acetoacetate</subject><subject>Acetoacetates - blood</subject><subject>Administration, Oral</subject><subject>AKBR</subject><subject>Alanine Transaminase - metabolism</subject><subject>Analgesics, Non-Narcotic - toxicity</subject><subject>Animals</subject><subject>Aspartate Aminotransferases - metabolism</subject><subject>Biological and medical sciences</subject><subject>Chemical and Drug Induced Liver Injury - blood</subject><subject>Chemical and Drug Induced Liver Injury - etiology</subject><subject>Dose-Response Relationship, Drug</subject><subject>gamma-Glutamyltransferase - metabolism</subject><subject>Glutathione peroxidase</subject><subject>Glutathione Peroxidase - blood</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Ketone Bodies - blood</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>Liver Function Tests</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Rabbits</subject><subject>Superoxide dismutase</subject><subject>Superoxide Dismutase - blood</subject><subject>β-hydoxybutyrate</subject><issn>0940-2993</issn><issn>1618-1433</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAURYMozjj6A9xIN7prfa9J2oZZyeAXDLgZ1yFNU8yQtmPSDvjvbZmCO1ePB-deLoeQW4QEAbPHfWL6Q5IC5AmwBICekSVmWMTIKD0nSxAM4lQIuiBXIewBUhAcL8kC8wwwx3RJ1rsvE9m2doNptYm6OgqNci6qumDC9B6UV9r0qulc1LWRV2Vp-8jZo_HX5KJWLpib-a7I58vzbvMWbz9e3zdP21gzmvexwDLPgVdClFpDzgSwEjRDrlIuCj6OAq4K5LxO64pnosaC0YxTrlmhaVrSFXk49R589z2Y0MvGBm2cU63phiBTYBnnmI0gnkDtuxC8qeXB20b5H4kgJ2NyL0djcjImgcnR2Ji5m8uHsjHVX2JWNAL3M6CCVq72qtU2_HECWXEqWp84M6o4WuNl0HaSWllvdC-rzv4z4xee7IX0</recordid><startdate>20071001</startdate><enddate>20071001</enddate><creator>Maciejewska-Paszek, Izabela</creator><creator>Pawłowska-Góral, Katarzyna</creator><creator>Kostrzewski, Marek</creator><creator>Kurzeja, Ewa</creator><creator>Wardas, Maria</creator><creator>Rzepecka-Stojko, Anna</creator><general>Elsevier GmbH</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20071001</creationdate><title>The influence of small doses of paracetamol on rabbit liver</title><author>Maciejewska-Paszek, Izabela ; Pawłowska-Góral, Katarzyna ; Kostrzewski, Marek ; Kurzeja, Ewa ; Wardas, Maria ; Rzepecka-Stojko, Anna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-91b7705d99bcc074904b0c415a2598502005a8155f2fd569f18436535c48c32b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>3-Hydroxybutyric Acid - blood</topic><topic>Acetaminophen - toxicity</topic><topic>Acetoacetate</topic><topic>Acetoacetates - blood</topic><topic>Administration, Oral</topic><topic>AKBR</topic><topic>Alanine Transaminase - metabolism</topic><topic>Analgesics, Non-Narcotic - toxicity</topic><topic>Animals</topic><topic>Aspartate Aminotransferases - metabolism</topic><topic>Biological and medical sciences</topic><topic>Chemical and Drug Induced Liver Injury - blood</topic><topic>Chemical and Drug Induced Liver Injury - etiology</topic><topic>Dose-Response Relationship, Drug</topic><topic>gamma-Glutamyltransferase - metabolism</topic><topic>Glutathione peroxidase</topic><topic>Glutathione Peroxidase - blood</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Ketone Bodies - blood</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Liver - pathology</topic><topic>Liver Function Tests</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pathology. 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| ispartof | Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie, 2007-10, Vol.59 (2), p.139-141 |
| issn | 0940-2993 1618-1433 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 3-Hydroxybutyric Acid - blood Acetaminophen - toxicity Acetoacetate Acetoacetates - blood Administration, Oral AKBR Alanine Transaminase - metabolism Analgesics, Non-Narcotic - toxicity Animals Aspartate Aminotransferases - metabolism Biological and medical sciences Chemical and Drug Induced Liver Injury - blood Chemical and Drug Induced Liver Injury - etiology Dose-Response Relationship, Drug gamma-Glutamyltransferase - metabolism Glutathione peroxidase Glutathione Peroxidase - blood Investigative techniques, diagnostic techniques (general aspects) Ketone Bodies - blood Liver - drug effects Liver - metabolism Liver - pathology Liver Function Tests Male Medical sciences Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Rabbits Superoxide dismutase Superoxide Dismutase - blood β-hydoxybutyrate |
| title | The influence of small doses of paracetamol on rabbit liver |
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