Is elevated urotensin II level a predictor for increased cardiovascular risk in subjects with acromegaly?
Purpose Acromegaly is a rare disorder existed in the result of overproduction of growth hormone (GH). The disorder is associated with increased cardiovascular risk factors and metabolic abnormalities. Urotensin II (UII), a secreted vasoactive peptide hormone, belonging somatostatin superfamily, play...
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Veröffentlicht in: | Journal of endocrinological investigation 2019-02, Vol.42 (2), p.207-215 |
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creator | Demirpence, M. Guler, A. Yilmaz, H. Sayin, A. Pekcevik, Y. Turkon, H. Colak, A. Ari, E. M. Aslanipour, B. Kocabas, G. U. Calan, M. |
description | Purpose
Acromegaly is a rare disorder existed in the result of overproduction of growth hormone (GH). The disorder is associated with increased cardiovascular risk factors and metabolic abnormalities. Urotensin II (UII), a secreted vasoactive peptide hormone, belonging somatostatin superfamily, plays an essential role in atherosclerosis and glucose metabolism. The aim of this study was to ascertain whether circulating UII levels are altered in subjects with acromegaly, and to describe the relationship between UII and hormonal or cardiometabolic parameters.
Methods
This cross-sectional study included 41 subjects with active acromegaly, 28 subjects with controlled acromegaly, and 37 age- and BMI-matched controls without acromegaly. Hormonal and metabolic features of the subjects as well as carotid intima media thickness (cIMT) and epicardial fat thickness (EFT) were defined. Circulation of UII levels was determined via ELISA.
Results
Both active and controlled acromegalic subjects showed a significant elevation of circulating levels of UII with respect to controls. There was no remarkable difference in circulating levels of UII between active and controlled acromegalic groups. Both cIMT and EFT were remarkably increased in acromegaly subjects comparing to controls. UII positively correlated with cIMT, EFT, BMI, and HOMA-IR. There was no correlation between UII and GH, insulin-like growth factor-1. According to the results obtained from regression models, UII levels independently predicted cIMT and EFT.
Conclusion
Elevated UII levels are associated with severity of cardiovascular risk factors including cIMT and EFT in acromegalic subjects. |
doi_str_mv | 10.1007/s40618-018-0905-1 |
format | Article |
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Acromegaly is a rare disorder existed in the result of overproduction of growth hormone (GH). The disorder is associated with increased cardiovascular risk factors and metabolic abnormalities. Urotensin II (UII), a secreted vasoactive peptide hormone, belonging somatostatin superfamily, plays an essential role in atherosclerosis and glucose metabolism. The aim of this study was to ascertain whether circulating UII levels are altered in subjects with acromegaly, and to describe the relationship between UII and hormonal or cardiometabolic parameters.
Methods
This cross-sectional study included 41 subjects with active acromegaly, 28 subjects with controlled acromegaly, and 37 age- and BMI-matched controls without acromegaly. Hormonal and metabolic features of the subjects as well as carotid intima media thickness (cIMT) and epicardial fat thickness (EFT) were defined. Circulation of UII levels was determined via ELISA.
Results
Both active and controlled acromegalic subjects showed a significant elevation of circulating levels of UII with respect to controls. There was no remarkable difference in circulating levels of UII between active and controlled acromegalic groups. Both cIMT and EFT were remarkably increased in acromegaly subjects comparing to controls. UII positively correlated with cIMT, EFT, BMI, and HOMA-IR. There was no correlation between UII and GH, insulin-like growth factor-1. According to the results obtained from regression models, UII levels independently predicted cIMT and EFT.
Conclusion
Elevated UII levels are associated with severity of cardiovascular risk factors including cIMT and EFT in acromegalic subjects.</description><identifier>ISSN: 1720-8386</identifier><identifier>ISSN: 0391-4097</identifier><identifier>EISSN: 1720-8386</identifier><identifier>DOI: 10.1007/s40618-018-0905-1</identifier><identifier>PMID: 29804270</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Acromegaly ; Acromegaly - blood ; Acromegaly - complications ; Adult ; Arteriosclerosis ; Biomarkers - blood ; Cardiovascular diseases ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - etiology ; Carotid Intima-Media Thickness ; Cross-Sectional Studies ; Endocrinology ; Enzyme-linked immunosorbent assay ; Female ; Glucose metabolism ; Growth hormones ; Humans ; Insulin ; Insulin Resistance - physiology ; Insulin-like growth factor I ; Male ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Metabolism ; Middle Aged ; Original Article ; Prognosis ; Regression analysis ; Risk Factors ; Somatostatin ; Urotensins - blood ; Vasoactive agents</subject><ispartof>Journal of endocrinological investigation, 2019-02, Vol.42 (2), p.207-215</ispartof><rights>Italian Society of Endocrinology (SIE) 2018</rights><rights>Copyright Springer Nature B.V. 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-d5b1ff35f17b752b219601275b49558347640a4a5f6cba8076dd07dfb5ac61f53</citedby><cites>FETCH-LOGICAL-c398t-d5b1ff35f17b752b219601275b49558347640a4a5f6cba8076dd07dfb5ac61f53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40618-018-0905-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40618-018-0905-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29804270$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Demirpence, M.</creatorcontrib><creatorcontrib>Guler, A.</creatorcontrib><creatorcontrib>Yilmaz, H.</creatorcontrib><creatorcontrib>Sayin, A.</creatorcontrib><creatorcontrib>Pekcevik, Y.</creatorcontrib><creatorcontrib>Turkon, H.</creatorcontrib><creatorcontrib>Colak, A.</creatorcontrib><creatorcontrib>Ari, E. M.</creatorcontrib><creatorcontrib>Aslanipour, B.</creatorcontrib><creatorcontrib>Kocabas, G. U.</creatorcontrib><creatorcontrib>Calan, M.</creatorcontrib><title>Is elevated urotensin II level a predictor for increased cardiovascular risk in subjects with acromegaly?</title><title>Journal of endocrinological investigation</title><addtitle>J Endocrinol Invest</addtitle><addtitle>J Endocrinol Invest</addtitle><description>Purpose
Acromegaly is a rare disorder existed in the result of overproduction of growth hormone (GH). The disorder is associated with increased cardiovascular risk factors and metabolic abnormalities. Urotensin II (UII), a secreted vasoactive peptide hormone, belonging somatostatin superfamily, plays an essential role in atherosclerosis and glucose metabolism. The aim of this study was to ascertain whether circulating UII levels are altered in subjects with acromegaly, and to describe the relationship between UII and hormonal or cardiometabolic parameters.
Methods
This cross-sectional study included 41 subjects with active acromegaly, 28 subjects with controlled acromegaly, and 37 age- and BMI-matched controls without acromegaly. Hormonal and metabolic features of the subjects as well as carotid intima media thickness (cIMT) and epicardial fat thickness (EFT) were defined. Circulation of UII levels was determined via ELISA.
Results
Both active and controlled acromegalic subjects showed a significant elevation of circulating levels of UII with respect to controls. There was no remarkable difference in circulating levels of UII between active and controlled acromegalic groups. Both cIMT and EFT were remarkably increased in acromegaly subjects comparing to controls. UII positively correlated with cIMT, EFT, BMI, and HOMA-IR. There was no correlation between UII and GH, insulin-like growth factor-1. According to the results obtained from regression models, UII levels independently predicted cIMT and EFT.
Conclusion
Elevated UII levels are associated with severity of cardiovascular risk factors including cIMT and EFT in acromegalic subjects.</description><subject>Acromegaly</subject><subject>Acromegaly - blood</subject><subject>Acromegaly - complications</subject><subject>Adult</subject><subject>Arteriosclerosis</subject><subject>Biomarkers - blood</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Carotid Intima-Media Thickness</subject><subject>Cross-Sectional Studies</subject><subject>Endocrinology</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Female</subject><subject>Glucose metabolism</subject><subject>Growth hormones</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin Resistance - physiology</subject><subject>Insulin-like growth factor I</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Prognosis</subject><subject>Regression analysis</subject><subject>Risk Factors</subject><subject>Somatostatin</subject><subject>Urotensins - blood</subject><subject>Vasoactive agents</subject><issn>1720-8386</issn><issn>0391-4097</issn><issn>1720-8386</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtrGzEUhUVJaFKnP6CbIMimm0muNKPHrEIxfRgC3SRrodFIrpzxjKM74-B_Hxm7SSh0cZDQ_e65kg4hXxhcMwB1gxVIpgvYqwZRsA_knCkOhS61PHm3PyOfEFcApSq1-kjOeK2h4grOSVwg9Z3f2tG3dErD6HuMPV0saD70HbV0k3wb3TgkGrJi75K3mGFnUxuHrUU3dTbRFPExVylOzcq7EelzHP9Q69Kw9kvb7W4vyGmwHfrPx3VGHn58v5__Ku5-_1zMv90Vrqz1WLSiYSGUIjDVKMEbzmoJjCvRVLUQuqyUrMBWVgTpGqtBybYF1YZGWCdZEOWMfD34btLwNHkczTqi811nez9MaDhU2bDKThm9-gddDVPq8-0MZ5oxXgopM8UOVH4LYvLBbFJc27QzDMw-B3PIwcBeOQfDcs_l0Xlq1r597fj78RngBwBzqV_69Db6_64v6p2SrQ</recordid><startdate>20190201</startdate><enddate>20190201</enddate><creator>Demirpence, M.</creator><creator>Guler, A.</creator><creator>Yilmaz, H.</creator><creator>Sayin, A.</creator><creator>Pekcevik, Y.</creator><creator>Turkon, H.</creator><creator>Colak, A.</creator><creator>Ari, E. M.</creator><creator>Aslanipour, B.</creator><creator>Kocabas, G. U.</creator><creator>Calan, M.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20190201</creationdate><title>Is elevated urotensin II level a predictor for increased cardiovascular risk in subjects with acromegaly?</title><author>Demirpence, M. ; Guler, A. ; Yilmaz, H. ; Sayin, A. ; Pekcevik, Y. ; Turkon, H. ; Colak, A. ; Ari, E. M. ; Aslanipour, B. ; Kocabas, G. U. ; Calan, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-d5b1ff35f17b752b219601275b49558347640a4a5f6cba8076dd07dfb5ac61f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acromegaly</topic><topic>Acromegaly - blood</topic><topic>Acromegaly - complications</topic><topic>Adult</topic><topic>Arteriosclerosis</topic><topic>Biomarkers - blood</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular Diseases - blood</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Carotid Intima-Media Thickness</topic><topic>Cross-Sectional Studies</topic><topic>Endocrinology</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Female</topic><topic>Glucose metabolism</topic><topic>Growth hormones</topic><topic>Humans</topic><topic>Insulin</topic><topic>Insulin Resistance - physiology</topic><topic>Insulin-like growth factor I</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Prognosis</topic><topic>Regression analysis</topic><topic>Risk Factors</topic><topic>Somatostatin</topic><topic>Urotensins - blood</topic><topic>Vasoactive agents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Demirpence, M.</creatorcontrib><creatorcontrib>Guler, A.</creatorcontrib><creatorcontrib>Yilmaz, H.</creatorcontrib><creatorcontrib>Sayin, A.</creatorcontrib><creatorcontrib>Pekcevik, Y.</creatorcontrib><creatorcontrib>Turkon, H.</creatorcontrib><creatorcontrib>Colak, A.</creatorcontrib><creatorcontrib>Ari, E. M.</creatorcontrib><creatorcontrib>Aslanipour, B.</creatorcontrib><creatorcontrib>Kocabas, G. U.</creatorcontrib><creatorcontrib>Calan, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of endocrinological investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Demirpence, M.</au><au>Guler, A.</au><au>Yilmaz, H.</au><au>Sayin, A.</au><au>Pekcevik, Y.</au><au>Turkon, H.</au><au>Colak, A.</au><au>Ari, E. M.</au><au>Aslanipour, B.</au><au>Kocabas, G. U.</au><au>Calan, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is elevated urotensin II level a predictor for increased cardiovascular risk in subjects with acromegaly?</atitle><jtitle>Journal of endocrinological investigation</jtitle><stitle>J Endocrinol Invest</stitle><addtitle>J Endocrinol Invest</addtitle><date>2019-02-01</date><risdate>2019</risdate><volume>42</volume><issue>2</issue><spage>207</spage><epage>215</epage><pages>207-215</pages><issn>1720-8386</issn><issn>0391-4097</issn><eissn>1720-8386</eissn><abstract>Purpose
Acromegaly is a rare disorder existed in the result of overproduction of growth hormone (GH). The disorder is associated with increased cardiovascular risk factors and metabolic abnormalities. Urotensin II (UII), a secreted vasoactive peptide hormone, belonging somatostatin superfamily, plays an essential role in atherosclerosis and glucose metabolism. The aim of this study was to ascertain whether circulating UII levels are altered in subjects with acromegaly, and to describe the relationship between UII and hormonal or cardiometabolic parameters.
Methods
This cross-sectional study included 41 subjects with active acromegaly, 28 subjects with controlled acromegaly, and 37 age- and BMI-matched controls without acromegaly. Hormonal and metabolic features of the subjects as well as carotid intima media thickness (cIMT) and epicardial fat thickness (EFT) were defined. Circulation of UII levels was determined via ELISA.
Results
Both active and controlled acromegalic subjects showed a significant elevation of circulating levels of UII with respect to controls. There was no remarkable difference in circulating levels of UII between active and controlled acromegalic groups. Both cIMT and EFT were remarkably increased in acromegaly subjects comparing to controls. UII positively correlated with cIMT, EFT, BMI, and HOMA-IR. There was no correlation between UII and GH, insulin-like growth factor-1. According to the results obtained from regression models, UII levels independently predicted cIMT and EFT.
Conclusion
Elevated UII levels are associated with severity of cardiovascular risk factors including cIMT and EFT in acromegalic subjects.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>29804270</pmid><doi>10.1007/s40618-018-0905-1</doi><tpages>9</tpages></addata></record> |
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subjects | Acromegaly Acromegaly - blood Acromegaly - complications Adult Arteriosclerosis Biomarkers - blood Cardiovascular diseases Cardiovascular Diseases - blood Cardiovascular Diseases - etiology Carotid Intima-Media Thickness Cross-Sectional Studies Endocrinology Enzyme-linked immunosorbent assay Female Glucose metabolism Growth hormones Humans Insulin Insulin Resistance - physiology Insulin-like growth factor I Male Medicine Medicine & Public Health Metabolic Diseases Metabolism Middle Aged Original Article Prognosis Regression analysis Risk Factors Somatostatin Urotensins - blood Vasoactive agents |
title | Is elevated urotensin II level a predictor for increased cardiovascular risk in subjects with acromegaly? |
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