Biomimetic mineralization of carboxymethyl chitosan nanofibers with improved osteogenic activity in vitro and in vivo

•Water-soluble uniform CMCS nanofibers were electrospun with the aid of PEO.•CMCS nanofibers enhanced the mineralization due to the introduction of −COOH.•CMCS-HA nanofibers promoted the osteogenesis both in vitro and in vivo. Inspired by the natural extracellular matrix, the organic-inorganic compo...

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Veröffentlicht in:	Carbohydrate polymers 2018-09, Vol.195, p.225-234
Hauptverfasser:	Zhao, Xiujuan, Zhou, Liangyu, Li, Qingtao, Zou, Qingxia, Du, Chang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomimetic Materials - chemical synthesis Biomimetic Materials - chemistry Biomimetic Materials - pharmacology Bone Marrow Cells - drug effects Bone Marrow Cells - metabolism Calcification, Physiologic Carboxymethyl chitosan Cells, Cultured Chitosan - analogs & derivatives Chitosan - chemistry Durapatite - chemistry Hydroxyapatite Male Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - metabolism Mice Nanofibers Nanofibers - chemistry Osteogenesis Osteogenic differentiation Rats Rats, Sprague-Dawley Tissue Scaffolds - chemistry
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