Vitamin D-restricted high-fat diet down-regulates expression of intestinal alkaline phosphatase isozymes in ovariectomized rats

Intestinal alkaline phosphatase (IAP) is expressed at a high concentration in the brush border membrane of intestinal epithelial cells. Intestinal alkaline phosphatase controls bacterial endotoxin-induced inflammation by dephosphorylating lipopolysaccharide and is a gut mucosal defense factor. Previ...

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Veröffentlicht in:	Nutrition research (New York, N.Y.) N.Y.), 2018-05, Vol.53, p.23-31
Hauptverfasser:	Nakaoka, Kanae, Yamada, Asako, Noda, Seiko, Goseki-Sone, Masae
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline phosphatase Alkaline Phosphatase - metabolism Animals Diet, High-Fat - adverse effects Dietary Fats - administration & dosage Dietary Fats - adverse effects Dietary vitamin D restriction Down-Regulation Duodenum - metabolism Duodenum - microbiology Female Gastrointestinal Microbiome High-fat diet Inflammation - blood Inflammation - enzymology Inflammation - etiology Intestinal alkaline phosphatase Intestinal Mucosa - metabolism Intestinal Mucosa - microbiology Isoenzymes - metabolism Lipopolysaccharides Menopause Ovariectomized rats Ovariectomy Rats RNA, Messenger - metabolism Vitamin D - administration & dosage Vitamin D - blood Vitamin D Deficiency - blood Vitamin D Deficiency - complications Vitamins - administration & dosage Vitamins - blood
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