A Tunable Ratchet Driving Human RNA Polymerase II Translocation Adjusted by Accurately Templated Nucleoside Triphosphates Loaded at Downstream Sites and by Elongation Factors

When nucleoside triphosphate (NTP) substrates and α-amanitin are added to a human RNA polymerase II elongation complex simultaneously, the reaction becomes stalled in the core of the bond synthesis mechanism. The mode of stalling is influenced by NTP substrates at the active site and at downstream s...

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Veröffentlicht in:	The Journal of biological chemistry 2007-12, Vol.282 (50), p.36582-36592
Hauptverfasser:	Xiong, Yalin, Burton, Zachary F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alpha-Amanitin - chemistry Deoxyribonucleotides - chemistry DNA - chemistry Humans Models, Molecular Ribonucleotides - chemistry RNA - biosynthesis RNA Polymerase II - antagonists & inhibitors RNA Polymerase II - chemistry Transcription Factors, TFII - chemistry Transcriptional Elongation Factors - chemistry
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