Analysis of the DPYD gene implicated in 5-fluorouracil catabolism in Chinese cancer patients

Summary Background and objective: 5‐fluorouracil (5‐FU) is still a widely used anticancer drug. More than 85% of the 5‐FU administered is catabolized by dihydropyrimidine dehydrogenase (DPD) in the liver. However, mutations in the DPD gene have been found to be associated with low DPD activity caus...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of clinical pharmacy and therapeutics 2008-06, Vol.33 (3), p.307-314
Hauptverfasser:	He, Y.-F., Wei, W., Zhang, X., Li, Y.-H., Li, S., Wang, F.-H., Lin, X.-B., Li, Z.-M., Zhang, D.-S., Huang, H.-Q., Hu, B., Jiang, W.-Q.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-fluorouracil Aged Analysis of Variance Antimetabolites, Antineoplastic - metabolism Antimetabolites, Antineoplastic - pharmacology Antimetabolites, Antineoplastic - therapeutic use Asian Continental Ancestry Group Biological and medical sciences China Chromatography, High Pressure Liquid dihydropyrimidine dehydrogenase Dihydrouracil Dehydrogenase (NADP) - genetics Dihydrouracil Dehydrogenase (NADP) - metabolism Exons Female Fluorouracil - metabolism Fluorouracil - pharmacology Fluorouracil - therapeutic use Gene Frequency Genotype Humans Male Medical sciences Mutation Neoplasms - drug therapy Neoplasms - enzymology Pharmacology. Drug treatments phenotype Polymerase Chain Reaction Sex Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!